Global ETD Search

1	Bone Healing in Diabetes Mellitus Associated Hyperglycemia Mahno, Elena 12 January 2011 (has links) Diabetes mellitus is a systemic condition that remains undiagnosed in a large portion of the population, which presents potential challenges for implant-based rehabilitation. Currently, the effects of diabetes on bone healing are not fully understood. Thus prior to employing a model of diabetes in studies of peri-implant healing, it was important to investigate the temporal effects of hyperglycemia on bone healing. Bone healing of femoral drill-defects was compared between streptozotocin-induced hyperglycemic (DB) and normoglycemic (NDC) rats at 5, 10, 15, and 30 days P.O. Quantitative assessment of bone samples using μCT demonstrated a delay in bone formation occurring up to 10 days in DB animals. Histological assessment confirmed these quantitative findings. Additionally, fluorescently stained bone samples indicated possible defects in mineralization of bone in DB group. In summary hyperglycemia affects bone healing at the early stages of bone formation, concurrent with the osteoconduction phase of bone healing. Diabetes Mellitus Bone Hyperglycemia Drill defect microcomputed tomography osteoconduction 0567
2	Bone Healing in Diabetes Mellitus Associated Hyperglycemia Mahno, Elena 12 January 2011 (has links) Diabetes mellitus is a systemic condition that remains undiagnosed in a large portion of the population, which presents potential challenges for implant-based rehabilitation. Currently, the effects of diabetes on bone healing are not fully understood. Thus prior to employing a model of diabetes in studies of peri-implant healing, it was important to investigate the temporal effects of hyperglycemia on bone healing. Bone healing of femoral drill-defects was compared between streptozotocin-induced hyperglycemic (DB) and normoglycemic (NDC) rats at 5, 10, 15, and 30 days P.O. Quantitative assessment of bone samples using μCT demonstrated a delay in bone formation occurring up to 10 days in DB animals. Histological assessment confirmed these quantitative findings. Additionally, fluorescently stained bone samples indicated possible defects in mineralization of bone in DB group. In summary hyperglycemia affects bone healing at the early stages of bone formation, concurrent with the osteoconduction phase of bone healing. Diabetes Mellitus Bone Hyperglycemia Drill defect microcomputed tomography osteoconduction 0567
3	The Comparative Performance of Micro- and Nano-topographically Complex Endosseous Implant Surfaces in Normoglycemic and Hyperglycemic Subjects Bell, Spencer 11 July 2013 (has links) Endosseous implants have notably high success rates, yet a small percentage of implants still fail for unidentified reasons. Recent literature points to hyperglycemia, resulting from untreated or undiagnosed diabetes, as a possible contraindication in an otherwise apparently healthy population. To investigate the effect of surface design on peri-implant healing in the presence of hyperglycemia, STZ-treated rats were implanted with custom rectangular implants of two surface topographies: grit blasted (GB) and grit-blast with a calcium phosphate nanotopography (GB-DCD). Tensile testing was conducted at 5, 7, and 9 days post-operative. Results demonstrated hyperglycemia to delay early stages of the peri-implant healing. Contact osteogenesis was increased along the GB-DCD surface, even in an environment of uncontrolled hyperglycemia, and the GB-DCD surface outperformed the GB surface in both healthy and hyperglycemic animals, showing peri-implant bone matured more rapidly on nanotopographically complex surfaces, even in the presence of uncontrolled hyperglycemia. Nano Surface Mechanical Testing Bone Bone-bonding Osteoconduction Contact osteogenesis de novo bone formation Implant design Titanium Calcium phosphate Hyperglycemia Diabetes Drill defect Bone healing Micro Surface Surface topography 0541

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