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The role of exosomes in nasopharyngeal carcinomaChan, Yuk Kit 01 January 2013 (has links)
No description available.
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Quantitative multiparametric imaging for the evaluation of nasopharyngeal carcinoma using PET and DCE-MRIHuang, Bingsheng, 黄炳升 January 2012 (has links)
Nasopharyngeal carcinoma (NPC) is an aggressive head and neck cancer ranked
as the 5th most common in Hong Kong. We aimed to study the role of dynamic
contrast-enhanced MRI (DCE-MRI) and dynamic 2-deoxy-2-[fluorine-18]fluoro
-D-glucose positron emission tomography (FDG-PET) for characterizing NPC
tumors in newly-diagnosed patients, and to quantitatively evaluate the
intratumoral heterogeneity of NPC.
In Chapter 2 we employed semi-quantitative analysis of DCE-MRI to study the
dynamic enhancement pattern by analyzing the time-intensity curves in 25 NPC
patients. Our findings suggested that high blood flow caused a high initial
intensity enhancement rate (ER), and that neovasculature due to tumor
angiogenesis in tumors of larger volume or higher T-stage caused more
accumulation of contrast agent which can be detected by DCE-MRI. PET and
semi-quantitative DCE-MRI parameters were not correlated and may reflect
different physiological/molecular processes in the microenvironment of NPC
tumor. However the major limitation of semi-quantitative analysis was that the
physiological correlates of these parameters were unclear.
In Chapter 3 we applied quantitative analysis of DCE-MRI to study the
permeability and perfusion characteristics in the same cohort as in Chapter 2.
Our findings implied that the permeability may be high compared to blood flow
in NPC tumor. We also observed significant correlations between iAUC (the
initial area under the time-intensity curve) by semi-quantitative analysis and ve
(the volume fraction of extravascular extracellular space) by quantitative analysis,
and between the two rate constants (kep’s) from these two methods, which
showed that semi-quantitative analysis was a feasible alternative in reflecting the
physiological characteristics of NPC. However, we did not observe any
significant correlation between PET and DCE-MRI quantitative parameters, also
suggesting that PET and DCE-MRI reflected different physiological information
in NPC.
In Chapter 4 we applied dynamic PET scan to study the glucose metabolism in
18 NPC tumors (16 included in DCE-MRI cohort). Our findings showed that
the overall FDG uptake was mainly composed of the FDG in tissue compartment
(Ki), which was governed by the phosphorylation (k3) but not the transport of
FDG (K1). This finding may further indicate a potential role of the
phosphorylation rate k3 in NPC. Dynamic PET parameters did not correlate
with DCE-MRI, indicating that the two modalities reflect different molecular
information in NPC.
In Chapter 5, intratumoral heterogeneity in NPC tumors of 40 patients was
studied using 18F-FDG PET scan. Our findings showed that as tumors grew to
a larger volume and higher T-stage, they showed more heterogeneous glucose
metabolism. It was found that more heterogeneous tumor was associated with
worse disease-free survival, indicating that tumor metabolic heterogeneity may
play an important role for NPC patient prognosis.
To summarize, these results showed that DCE-MRI and dynamic PET improved
our understanding about the physiological/molecular process of NPC, and, these
two modalities reflected different physiological information in the
microenvironment of NPC tumors. This indicated that the relationship between
supply of nutrients such as glucose and blood flow/permeability is complex and
not directly related. Moreover, intratumoral heterogeneity by PET scan was
also of importance in prognostication. / published_or_final_version / Diagnostic Radiology / Doctoral / Doctor of Philosophy
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Illness trajectory of patients suffering from nasopharyngeal carcinoma /Cheng, Yuk-yi, Josephine. January 1997 (has links)
Thesis (M. Soc. Sc.)--University of Hong Kong, 1997. / Includes bibliographical references (leaf 138-147).
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The adjustment process of patients suffering from neoplasm of nasopharynx throughout the course of illness : a panel study in Hong Kong /Ma, Lai-chong. January 1995 (has links)
Thesis (Ph. D.)--University of Hong Kong, 1995. / Includes bibliographical references.
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Curcumin inhibits cell migration of nasopharyngeal carcinoma through reactivation of e-cadherin expressionChan, Wing-san, January 2009 (has links)
Thesis (M. Phil.)--University of Hong Kong, 2009. / Includes bibliographical references (leaves 101-124) Also available in print.
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Illness trajectory of patients suffering from nasopharyngeal carcinomaCheng, Yuk-yi, Josephine. January 1997 (has links)
Thesis (M.Soc.Sc.)--University of Hong Kong, 1997. / Includes bibliographical references (leaf 138-147) Also available in print.
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High-dose-rate intracavitary brachytherapy in the treatment of nasopharyngeal carcinoma梁道偉, Leung, To-wai. January 2007 (has links)
published_or_final_version / abstract / Medicine / Master / Doctor of Medicine
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Nasopharyngectomy with the da Vinci Surgical RobotTsang, King-yin, Raymond, 曾敬賢 January 2015 (has links)
Nasopharyngeal carcinoma (NPC) is the 7th commonest cancer in Hong Kong. Improvements in radiotherapy had increased the cure. Unfortunately, up to 10% of the patient still suffered from local recurrence. Because of the deep location, nasopharyngectomy was considered a difficult operation. Developments in surgical approaches had now established nasopharyngectomy as a standard salvage for locally recurrent NPC. With improvements of endonasal endoscopic instruments and endoscopic techniques, endoscopic nasopharyngectomy as a minimally invasive surgery for salvaging small locally recurrent NPC have been reported in several cohorts with encouraging results. Robotic nasopharyngectomy remained difficult due to tight operation space and instrument considerations.
The da Vinci surgical robot was marketed in 1999 as a tool to assist surgeons in performing complex surgical manipulations in tight spaces. It was later adapted to be used in the upper aerodigestive tract for endoscopic resection of small cancers transorally. As the da Vinci surgical robot was not designed for head and neck operations, adaptations are required when we tried to apply it to resect tumours in the nasopharynx.
The present study aimed to develop the use of the da Vinci surgical robot to perform minimally invasive operations on the nasopharynx in a cadaveric model. Ten procedures on 3 cadavers were performed with the surgical robot. Due to instrument clutter, a transoral approach was preferred over transnasal approach. In transoral approach, the soft palate obstructs the access to the nasopharynx. We devised three approaches, namely palatal suspension approach, midline palatal split approach and lateral palatal flap approach. We also assess the advantages and limitations of the three approaches.
From 2010-2014, 18 robotic nasopharyngectomies were performed. Median operation time was 232 minutes (range 125-574). Estimated median blood loss was 100ml (range 100-1800). Negative margins were achieved in 14 patients. The two-year actuarial local control was 83% and estimated mean survival was 42.7 months (95% confidence interval 35.0-50.3 months). A positive or close margin was significant associated with poor local control but not overall survival. Results were comparable to open or endoscopic nasopharyngectomy.
There was no 30 days post-operative mortality but one patient suffered from hypoxic brain damage after developing angioedema in the recovery room. Two patients developed permanent palatal fistulas and one patient had severe trismus after operation. Symptomatic osteoradionecrosis occurred in three patients.
When comparing the quality of life assessment with patients after open maxillary swing nasopharyngectomy operation, robotic nasopharyngectomy patients have a higher score in social functioning scale and lower symptoms scores on pain, mouth opening and social eating. The global health score and other functioning scores were statistically not different.
Robotic nasopharyngectomy is a feasible minimally invasive operation for resecting selected cases of locally recurrent NPC. The operation is associated with minor long-term complications and better quality of life. Early oncological results in are also encouraging. With rapid development of medical robotic technologies, further research in the field should be continued. / published_or_final_version / Surgery / Master / Master of Surgery
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Identification of candidate tumor suppressive BLU/ZMYND 10-modulated genes in nasopharyngeal carcinomaChan, King-chi., 陳敬慈. January 2010 (has links)
published_or_final_version / Clinical Oncology / Doctoral / Doctor of Philosophy
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Characterization of the tumor suppressive function of alphaB-crystallin (CRYAB) in nasopharyngeal carcinomaHuang, Zhiguang, 黄之光. January 2011 (has links)
published_or_final_version / Clinical Oncology / Doctoral / Doctor of Philosophy
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