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A silicon based regeneration electrode for implantation in amphibiaRose, Christopher January 1981 (has links)
Thesis (M.S.)--Massachusetts Institute of Technology, Dept. of Electrical Engineering and Computer Science, 1981. / MICROFICHE COPY AVAILABLE IN ARCHIVES AND ENGINEERING. / Vita. / Bibliography: leaves 109-112. / by Christopher Rose. / M.S.
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Effect of whole-body vibration on painful diabetic peripheral neuropathyGuzman, Ruben J. (Ruben Jacobo) 05 June 2012 (has links)
Introduction. Painful diabetic peripheral neuropathy (DPN) is a common
complication of diabetes that interferes with daily living and causes severe
pain. Pharmacotherapy is the accepted treatment strategy, however, this
strategy is associated with high cost, minimal reductions in pain, and adverse
side effects. Thus, a critical need exists to develop alternative treatment
strategies. Purpose. To determine if a 12-week whole-body vibration (WBV)
intervention reduces pain in adults with DPN. Methods. Twenty-one adults
with physician confirmed painful DPN volunteered to take part in a 26-week
time series design study. Pain was assessed with the Brief Pain Inventory
Short Form [BPI-sf] and a 0-10 numeric rating scale [NRS]. The BPI-sf
contains two indices that respectively measure how pain interferes with daily
living and severity. The intervention began after a 12-week control period. At
week 13, participants were asked to stand on a WBV machine 3 d/week for 4,
3-min bouts at 30-50 Hz with 1-min rest intervals between bouts. Pain levels
were reported using the NRS before and after each bout. Results. Comparing
post- to pre-intervention, BPI-sf pain interference scores decreased from
5.61±1.40 to 2.39±1.82 (p≤0.001). BPI-sf pain severity scores decreased
from 5.1±0.64 to 3.1±1.87 (p≤0.01). Analyses of the NRS scores indicate
that pain decreased each week following WBV and that between weeks, pain
continued to decrease. Conclusion. These findings demonstrate that whole-body
vibration was effective at reducing pain in a sample of adults with painful
DPN. / Graduation date: 2012
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On laminins and laminin receptors and their role in regeneration and myelination of the peripheral nerve /Wallquist, Wilhelm, January 2004 (has links)
Diss. (sammanfattning) Stockholm : Karol inst., 2004. / Härtill 4 uppsatser.
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Licking rate adaptations in response to increased mandibular weight in the adult rat a thesis submitted in partial fulfillment ... for the degree of Master of Science in Orthodontics ... /Carvalho, Thais Coelho. January 2001 (has links)
Thesis (M.S.)--University of Michigan, 2001. / Includes bibliographical references.
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Estimation of the distribution of conduction velocities in intact peripheral nervesJanuary 1977 (has links)
by Zsolt Laszlo Kovacs. / Bibliography: p. 175-184. / Originally presented as the author's thesis, (Ph.D.) in the M.I.T. Dept. of Electrical Engineering and Computer Science, 1977. Partial support provided by the Funda? de Amparo a Pesquisa do Estado de S?Paulo, Brazil and by the National Science Foundation Grant no. NSF/ENG-7705200.
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Estudo histopatológico da implantação de nervo periférico no osso /Varanda, Denis. January 2015 (has links)
Orientador: Érika Veruska de Paiva Ortolan / Coorientador: Trajano Sardenberg / Banca: Evandro Pereira Palácio / Banca: Gilberto José Cação Pereira / Resumo: Introdução - Há diversas técnicas cirúrgicas para o tratamento dos neuromas doloridos, porém não há consenso em relação a mais eficaz. A implantação do neuroma ou do nervo dentro do osso é uma das cirurgias que proporciona bons resultados clínicos. Contudo, não há conhecimento detalhado sobre o destino do nervo ou neuroma implantado no osso. Objetivos - Os objetivos do estudo foram desenvolver modelo experimental de implantação de nervo no osso e analisar morfologicamente o destino no nervo implantado no osso. Material e Métodos - 24 ratos foram submetidos à implantação do nervo tibial caudal no terço distal do fêmur e estudados histológicamente nos períodos de 1, 3, 6, 13, 24 e 28 semanas por meio de microscopia ótica. Conclusões - Análise das imagens demonstrou que a implantação do nervo no osso desencadeia processo inflamatório que evolui da fase aguda para integração nervo-osso, sem formação de neuroma / Abstract: Introduction - There are several surgical techniques for treatment of painful amputation neuroma. However no consensus has already been reached on the most effective treatment. Burying the neuroma or the nerve in the bone is one of the surgeries which provides good clinical findings. However, there is no deep knowledge of what happens to the nerve or buried neuroma in the bone. Objectives - The objectives of this study were to develop an experimental model of this surgical technique and to morphologically analyze the destiny of the implanted nerve in the bone. Materials and Methods - A total of 24 four rats underwent implantation of the caudal tibial nerve in the distal third of the femur. They were histologically studied in the periods of 1, 3, 6, 13, 24 and 28 weeks by optical microscopy. Conclusion - The analyses of the images showed that implantation of the nerve in the bone triggers an inflammatory response which evolves from the acute phase to the nerve-bone integration with no formation of neuroma / Mestre
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Estudo histopatológico da implantação de nervo periférico no ossoVaranda, Denis [UNESP] 20 February 2015 (has links) (PDF)
Made available in DSpace on 2015-12-10T14:23:00Z (GMT). No. of bitstreams: 0
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000847943.pdf: 798739 bytes, checksum: f53b118e7c183c9c7d1e749a4ec9955a (MD5) / Introdução - Há diversas técnicas cirúrgicas para o tratamento dos neuromas doloridos, porém não há consenso em relação a mais eficaz. A implantação do neuroma ou do nervo dentro do osso é uma das cirurgias que proporciona bons resultados clínicos. Contudo, não há conhecimento detalhado sobre o destino do nervo ou neuroma implantado no osso. Objetivos - Os objetivos do estudo foram desenvolver modelo experimental de implantação de nervo no osso e analisar morfologicamente o destino no nervo implantado no osso. Material e Métodos - 24 ratos foram submetidos à implantação do nervo tibial caudal no terço distal do fêmur e estudados histológicamente nos períodos de 1, 3, 6, 13, 24 e 28 semanas por meio de microscopia ótica. Conclusões - Análise das imagens demonstrou que a implantação do nervo no osso desencadeia processo inflamatório que evolui da fase aguda para integração nervo-osso, sem formação de neuroma / Introduction - There are several surgical techniques for treatment of painful amputation neuroma. However no consensus has already been reached on the most effective treatment. Burying the neuroma or the nerve in the bone is one of the surgeries which provides good clinical findings. However, there is no deep knowledge of what happens to the nerve or buried neuroma in the bone. Objectives - The objectives of this study were to develop an experimental model of this surgical technique and to morphologically analyze the destiny of the implanted nerve in the bone. Materials and Methods - A total of 24 four rats underwent implantation of the caudal tibial nerve in the distal third of the femur. They were histologically studied in the periods of 1, 3, 6, 13, 24 and 28 weeks by optical microscopy. Conclusion - The analyses of the images showed that implantation of the nerve in the bone triggers an inflammatory response which evolves from the acute phase to the nerve-bone integration with no formation of neuroma
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Effects of insulin treatment on the morphology of peripheral nerve in alloxan-induced diabetic rats and their controlsFarber, Shereen D. January 1985 (has links)
This document only includes an excerpt of the corresponding thesis or dissertation. To request a digital scan of the full text, please contact the Ruth Lilly Medical Library's Interlibrary Loan Department (rlmlill@iu.edu).
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An in vitro study of the mechanisms that underlie changes in neuronal sensitivity and neurite morphology following treatment with microtubule targeting agentsPittman, Sherry Kathleen 11 1900 (has links)
Microtubule targeting agents (MTAs) are chemotherapeutics commonly
used in the treatment of breast, ovarian, lung, and lymphoma cancers. There are
two main classes of MTAs based upon their effects on microtubule stability. The
two classes are the destabilizing agents, which include the drug vincristine, and
the stabilizing agents, which include paclitaxel and epothilone B. These drugs
are highly effective antineoplastics, but their use is often accompanied by several
side effects, one of which is peripheral neuropathy. Peripheral neuropathy can
be characterized by burning pain, tingling, loss of proprioception, or numbness in
the hands and feet. In some patients, the MTA-induced peripheral neuropathy is
debilitating and dose-limiting; however, there are no effective prevention
strategies or treatment options for peripheral neuropathy as the mechanisms
mediating this side effect are unknown. The goal of this work was to investigate
MTA-induced effects on neuronal activity and morphology in order to elucidate
the underlying mechanisms involved in the development of MTA-induced
peripheral neuropathy.
As an indicator of sensory neuronal activity, the basal and
stimulated release of the putative nociceptive peptide, calcitonin gene-related
peptide (CGRP), was measured from sensory neurons in culture after exposure to the MTAs paclitaxel, epothilone B, and vincristine. Neurite length and
branching were also measured in sensory neuronal cultures after treatment with
these MTAs. The results described in this thesis demonstrate that MTAs alter
the stimulated release of CGRP from sensory neurons in differential ways
depending on the MTA agent employed, the CGRP evoking-stimulus used, the
concentration of the MTA agent, the duration of exposure to the MTA agent, and
the presence of NGF. It was also observed that MTA agents decrease neurite
length and branching, independent of the concentration of NGF in the culture
media. Thus, this thesis describes MTA-induced alterations of sensory neuronal
sensitivity and neurite morphology and begins to elucidate the underlying
mechanisms involved in MTA-induced alterations of sensory neurons. These
findings will undoubtedly be used to help elucidate the mechanisms underlying
MTA-induced peripheral neuropathy.
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Conduction block in peripheral nerves: effect of high frequency stimulation on different fiber typesJoseph, Laveeta 24 August 2010 (has links)
Selective stimulation and conduction block of specific nerve fibers has been a major area of research in neuroscience. The potential clinical and neurophysiological applications have warranted reliable techniques for transiently blocking conduction through nerves. High Frequency Alternating Current (HFAC) waveforms have been found to induce a reversible and repeatable block in peripheral nerves; however the effect of these waveforms on the neural activity of individual fiber types is currently unknown. Understanding this effect is critical if clinical applications are to be pursued. This dissertation work utilized extracellular electrophysiological techniques to characterize the activity of different fiber type populations in peripheral nerves during application of HFAC waveforms. First, we investigated the phenomenon in the homogeneous unmyelinated nerves of the sea-slug, Aplysia californica. Although complete reversible block was demonstrated in these nerves, a non-monotonic relationship of block threshold to frequency was found which differed from previously published work in the field. We then investigated the effect of HFAC waveforms on amphibian mixed nerves and studied the response of specific fiber types by isolating different components of the compound action potential. We validated our results from the Aplysia nerves by determining the block thresholds of the larger diameter, myelinated A-fibers and comparing them with those of the smaller diameter, unmyelinated C-fibers. We also showed that block threshold behavior during application of the HFAC waveform depends on the nerve fiber type, and this property can be used to selectively block specific fiber types. Finally, we examined the recovery time after block induction in unmyelinated nerves and found that recovery from block was dependent on the duration of application of the HFAC waveform. The time-dependent distribution of the recovery time and the non-monotonic threshold behavior in the smaller diameter unmyelinated nerves indicate that multiple mechanisms are involved in block induction using HFAC waveforms, and these mechanisms are dependent not only on the blocking stimulus but also on the characteristics of the nerve fiber. Overall, this work demonstrates that HFAC waveforms may enable inherent peripheral nerve properties to be exploited for potential clinical applications related to the treatment of unwanted neural activity.
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