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  • About
  • The Global ETD Search service is a free service for researchers to find electronic theses and dissertations. This service is provided by the Networked Digital Library of Theses and Dissertations.
    Our metadata is collected from universities around the world. If you manage a university/consortium/country archive and want to be added, details can be found on the NDLTD website.

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Spelling suggestions: "subject:"niemannpick C1 disease"" "subject:"hiemannian C1 disease""

1

Relative efficacy of nicotinamide treatment of a mouse model of infantile Niemann-Pick C1 disease

Marshall, Craig A., Borbon, Ivan A., Erickson, Robert P. 25 October 2016 (has links)
Nicotinamide delivered in drinking water at about 2 g/kg/day significantly prolonged survival and showed a suggestive improvement on memory in the Npc1 (nih) / Npc1 (nih) mouse model of infantile NPC1 disease. It is likely that this role is due to its function as a histone deacetylase (HDAC) inhibitor although another HDAC inhibitor, valproic acid, was without effect. Nicotinamide could also work by preventing/reversing oxidative stress.
Histone deacetylase
Nicotinamide
Niemann-Pick C1 disease
Oxidative stress
Sirtuin
Valproic acid

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