Aim: The aim of this study was to establish normal values for Schirmer tear test (version 2) and tear break up time (TBUT) in a South African young adult Black population. Method: Following ethical approval by the biomedical research and ethics committee, KwaZulu-Natal, participants were recruited from the city of Durban in South Africa via personal invitations, poster advertisements and University of KwaZulu-Natal optometry clinic clients. McMonnies questionnaire for dry eye diagnosis was administered and those who failed were excluded from the main study. Two hundred (100 males and 100 females) participants who met the inclusion criteria were included in the study. Following a slit lamp examination of the eye, the Schirmer test was administered and the following day, the TBUT was measured. A re-test version of the two procedures were conducted one week after, at about the same time of the day for each subject. Results: The participants were aged 18-30 years, mean = 20.77 ± 2.29 years. The mean Schirmer test values for all participants (N = 200; 400 eyes) was 15.96 ± 6.86mm. The values for the males and females (200 eyes each) were 16.34 ± 6.93mm and 15.58 ± 6.81mm respectively. The mean TBUT (400 eyes) was 7.18 ± 1.89 secs. The mean values for the males and females (200 eyes each) were 6.90 ± 1.88 secs and 7.32 ± 1.67 secs respectively. A strong positive correlation (r = 0.895) and (r = 0.914) respectively was found between the right and left eyes in the two tests. Conclusion: Generally, the mean values found in this study for the Schirmer test are similar to those that have been reported in the literature. However, values for TBUT differ from the values that have been previously reported, being higher in some instances and lower in others. These findings have implications for dry eye diagnosis and also contact lens practice in South Africa. / Thesis (M.Optom.)-University of KwaZulu-Natal, Westville, 2012.

No description available.

Current research interest in multi-scale modeling of cement paste requires accurate characterization of the time-dependent mechanical properties of the material, particularly the C-S-H phase. Nanoindentation is evaluated as a tool for measuring both the instantaneous and the short-term viscoelastic properties of cement paste. Atomic force microscopy (AFM) based indentation is compared to conventional nanoindentaion in measuring mechanical properties of cement pastes. Time-dependent solutions are derived to characterize creep indentation tests performed on hardened cement paste and to extract the time-dependent properties. The effect of approximating C-S-H viscoelastic properties with a time-independent Poisson's ratio is discussed, and arguments for utilizing a time-independent Poisson's ratio for short-term response are presented. In evaluating AFM as a mechanical characterization tool, various analytical and numerical modeling approaches are compared. The disparities between the numerical self-consistent approach and analytical solutions are determined and reported. The measured elastic Young's modulus values acquired by AFM indentation tests are compared to Young's modulus values from nanoindentation measurements from cement paste. These results show that the calcium silicate hydrate (C-S-H) phase of hydrated portland cement has different properties on the nanometric scale than on the micron scale. Packing density of C-S-H particles is proposed as an explanation for the disparity in the measured results. The AFM measured uniaxial viscoelastic compliance values are compared to similar values obtained with traditional nanoindentation for the same material. The comparison of these results shows that the calcium silicate hydrate (C-S-H) phase of portland cement has similar but distinct properties on the sub micron scale than on the micron scale. Additionally, the effect of moisture is evaluated by controlling the relative humidity (RH) of the testing environment between 40% and 100% plus, or wet. The viscoelastic compliance appears to be highest at 40% RH and the material appears to be less compliant at higher relative humidity levels. Possible mechanisms controlling the viscoelastic deformation are presented and evaluated in conjunction with the moisture related poromechanical effect.

This thesis is a sociolinguistic investigation into the use of local referent honorific suffixes by speakers of Osaka Japanese (OJ). Its main goal is to add to our understanding of the variation and change in the use of honorification among Japanese speakers, by including a combination of methodologies and frameworks within the scope of one discussion. The analysis covers both local referent honorific suffixes HARU, YARU and YORU, as well as Standard Japanese forms, (RA)RERU and so called special verbs. The main focus, however, is on providing a detailed examination of the local referent honorific suffix HARU. An analysis of the distribution patterns of this honorific allows us to explore (i) ongoing changes in its use across three generations of speakers, and (ii) the indexicality of its meaning in use, including the changing social meanings attached to the form see in the analysis of interactions, distribution and metapragmatic comments. The analysis shows that the use of both local and standard honorifics in informal conversations of OJ users is decreasing significantly among younger speakers. However, it also highlights the different linguistic behaviour of young men and young women in this speech community, and links their use of HARU with local linguistic and cultural ideologies, showing how they may be affecting both perceptions and patterns of use of the form. Additionally, the analysis in this dissertation looks at various levels of linguistic structure, allowing us to explore whether the Osaka honorific system does indeed function as a single system, or whether different forms at different levels of linguistic structure have their own histories and trajectories. The analysis suggests that the honorific resources available to OJ users (both standard and local features) need to be seen as a continuum (cf. Okamoto 1998), rather than separate and distinct systems. Both qualitative and quantitative methods are employed in the analysis. The quantitative analysis investigates the ongoing changes in the frequency of use of HARU, as well as its distribution according to a range of social and linguistic functions. The qualitative analysis suggests that HARU is socially meaningful for the speakers, performing multiple functions in the interpersonal domain of discourse. Combining the two approaches to study Japanese honorifics in naturally occurring conversations is an attempt at bridging the gap between a number of previous studies.

This dissertation presents contact force sensors that are based on an emerging fibre-optic sensing technology, the in-fibre Bragg grating (FBG), for contact force measurements between cartilage surfaces in the human hip. There are two main motivations for force measurement in hips (and other joints). First, there is clinical evidence that suggests excessive force magnitude and duration can cause painful degeneration of joints. Second, insights from ex vivo force measurements during simulated physiologic loading are the basis of the rationale for corrective surgeries meant to halt degeneration and restore proper joint function by restoring natural joint mechanics. The current standard tools for force measurements in joints are force/stress sensitive films. There are problems associated with inserting these films into joints that affect the force/stress measurements. To insert the films, the joint must be dissected of surrounding soft tissues and, ultimately, the joint must be taken apart (disarticulated). Following disarticulation, films are fixed to cartilage surfaces, and the joint is re-assembled so that physiologic loads can be applied. The negative consequence of dissection and disarticulation is that the natural mechanics of the intact joint are permanently lost and, therefore, film measurements do not indicate the actual joint mechanics. Moreover, covering cartilage surfaces with rigid films alters the natural contact mechanics of the joint. The force sensors presented in this dissertation are designed for local force measurement over the region of the optical fibre containing the FBG and address limitations of force/stress sensitive films. The FBG force sensors are extremely small (major diameters ranging from 0.165 mm to 0.24 mm) and can be inserted into joint spaces without dissection of soft tissues and disarticulation thereby allowing the joint to remain intact. Theoretical and experimental results indicate that FBG sensor measurements are less affected by the mechanical properties of cartilage than are film sensors. The sensors presented in this dissertation also address limitations with previous FBG based force sensors and are the first application of FBGs in intact human hips. The sensors are smaller, and therefore less invasive, and insensitive to orientation, axial strain and temperature, unlike other FBG sensors presented in the literature. / Graduate

The purpose of this study is to increase understanding of how parents of children in need of special support have experienced their interaction with the pre-school. Our three main areas of interest were to investigate how several parents experienced their contact with the pre-school, if there were any experienced factors that had played a part in the contact with the pre-school and if we could conclude anything about how the curriculum had been followed in these cases, with assistance of the parents’ experiences. Our study is qualitative and we chose to interview six parents. We both participated in all of the interviews. The theoretical base of this study is rooted in the phenomenological theory and we also used the framework factor theory to complement our analysis. One of our conclusions was that the parents expressed so many different experiences that we decide not to try compare them in general. On the other hand, all of the parents expressed that they were the ones who knew their children best and due to that, another conclusion that we interpreted was that the pre-school educators should pay attention to the parents so as to ensure that their contact would work as well as possible.

The presence of a sex difference in mutual eye-to-eye contact in dyadic interaction is well documented from late infancy through adulthood with females making more mutual eye contact than males. Only one study (Hittelman & Dickes, 1979) found evidence for this behavior pattern in newborns, but no research has been done to follow-up these findings. Systematic examination of the development of sex differences in mutual gaze behavior can aid in unraveling the differential effects of biological and social influences on the development of gendered social behavior. / This project was a longitudinal, within participants replication and extension of Hittelman and Dickes study: Seventy neonates (32 female, 38 male) age 13--112 hours postpartum and their parents participated in the Time 1 data collection, and 23 (9 female, 14 male) infants and their parents were seen a second time at 13--18 weeks postpartum (Time 2). Mutual gaze between the infant and two interacters (1 female, 1 male) was measured, and parents completed the Parental Sex-Typing of Newborns (Paston) Rating Scale to measure their sex-typed perceptions of newborns and young infants. / Results indicated: (a) No empirical evidence for sex differences at Time 1; (b) Strong evidence for sex differences in mutual gaze behavior at Time 2 indicating development of this sex-typed pattern in early infancy; (c) The emergence of sex differences in mutual gaze behavior from Time 1 to Time 2 is entirely accounted for by a radical change in female infants' gaze behavior; and (d) Empirical evidence linking mothers' sex-typed beliefs about their infants and infants' sex-typed gaze behavior. / Results are discussed within the theoretical contexts of the social learning and biological perspectives. This study demonstrates that infants' sex-typed behavior and mothers' gender-typed perceptions begin early in life. It is concluded that sex differences in mutual gaze behavior are a complex interplay of biological or social forces acting in concert. Subsequent research in this area should focus on the specific forces involved in bringing sex differences in mutual gaze behavior to fruition.

To attract more customers and compete with other modes of transportation, railway transport needs to ensure safety, punctuality, high comfort, and low cost; wheel–rail adhesion, i.e., the transmitted tangential force in the longitudinal direction during driving and braking, plays an important role in all these aspects. Adhesion needs to be kept at a certain level for railway operation and maintenance. However, wheel−rail contact is an open system contact. Different contaminants can present between the wheel and rail surfaces, forming a third-body layer that affects the adhesion. Prediction of wheel–rail adhesion is important for railway operations and research into vehicle dynamics; however, this prediction is difficult because of the presence of contaminants. This thesis deals with wheel–rail adhesion from a tribological perspective. The five appended papers discuss wheel–rail adhesion in terms of dry conditions, lubricated conditions, leaf contamination, iron oxides, and environmental conditions. The research methodologies used are numerical modelling, scaled laboratory experiments, and field tests. The research objective is to understand the mechanisms of the adhesion loss phenomenon.  A numerical model was developed to predict wheel–rail adhesion based on real measured 3D surfaces. Computer simulation indicates that surface topography has a larger impact on lubricated than on dry contacts. Plastic deformation in asperities is found to be very important in the model. Ball-on-disc tests indicate that water can give an extremely low adhesion coefficient on smooth surfaces, possibly due to surface oxidation. Investigation of lubricated contacts at low speed indicates that oil reduces the adhesion coefficient by carrying a normal load, while adhesion loss due to water depends on the surface topography, water temperature, and surface oxidation. A field investigation indicates that leaves reduce the friction coefficient because of the chemical reaction between leaves and bulk materials. The thickness of the surface oxide layer was found to be an essential factor determining adhesion reduction. Pin-on-disc experiments found a transition in the friction coefficient with regard to the relative humidity, due to a trade-off between the water molecule film and the hematite on the surface. / <p>QC 20131031</p>

Surfactant flooding in carbonate matrix acidizing treatment has been widely used for changing the wettability of the rock and to achieve low IFT values. Optimizing the type of surfactant and concentration for the specific oil field is very important in order to avoid formation damage and to reduce the treatment cost. We built an experimental procedure for screening the right surfactant to alter the wettability and aid in acidizing of Pekisko formation, Canada, which is strongly oil-wet and has high viscosity oil. Five surfactants were tested out of which three are cationic, one amphoteric and the other one was a fluoro-surfactant. Measurements were made of interfacial tension with different surfactant types/concentrations in brine with the oil and xylene, critical micelle concentration of each surfactant, solubility characteristics of the surfactants, compatibility of the chemical additives, wettability of the core after treating with surfactants, and core flooding in the laboratory to simulate matrix acidizing. From the results obtained we noted that the fluoro-surfactant can cause formation damage due to precipitation in the brine. So the compatibility of every chemical additive should be tested first. The use of xylene as a pre-flush solution lowered the CMC and hence reduced the cost of the surfactant treatment. Aromox, an amine based surfactant was best suited for matrix acidizing treatment of the Pekisko formation.

Purpose To examine soft contact lens fitting characteristics using anterior segment imaging techniques and comfort. The specific aims of each chapter are as follows: Chapter 2: To calibrate the new ZEISS VisanteTM anterior segment optical coherence tomographer (OCT) using references with known physical thickness and refractive index equal to the human cornea and to compare the Visante measures to those from a previous generation OCT (Zeiss-Humphrey OCT II). Chapter 3: The first purpose of this study was to measure the repeatability of the Visante TM OCT in a normal sample. The second was to compare corneal thickness measured with the Visante TM OCT to the Zeiss-Humphrey OCT II (model II, Carl Zeiss Meditec, Jena Germany) adapted for anterior segment imaging and to the Orbscan II TM (Bausch and Lomb, Rochester New York). Chapter 4: Conjunctival displacement observed with the edges of the contact lens, when imaged may be real or may be an artefact of all OCT imagers. A continuous surface appears displaced when the refractive index of the leading medium changes at the edge of a contact lens. To examine this effect, edges of the contact lenses were imaged on a continuous surface using the UHR-OCT. Contact lens edges on the human conjunctival tissue were also imaged to see if the lens indentation on the conjunctival tissue is real or an artefact at the edge of the lens. Chapter 5: The main purpose of this study was to determine if we can predict end of the day discomfort and dryness using clinical predictive variables. The second purpose of the study was to determine if there was any relationship between lens fitting characteristics and clinical complications and especially to the superior cornea and conjunctiva with a dispensing clinical trial. Methods Chapter 2: Twenty two semi-rigid lenses of specified thicknesses were manufactured using a material with refractive index of 1.376. Central thickness of these lenses was measured using VisanteTM OCT and Zeiss-Humphrey OCT II (Zeiss, Germany). Two data sets consisting of nominal measures (with a standard pachymeter of the lenses and one obtained using a digital micrometer) were used as references. Regression equations between the physical and optical (OCT) measures were derived to calibrate the devices. Chapter 3: Fifteen healthy participants were recruited. At the Day 1 visit the epithelial and total corneal thickness, across the central 10mm of the horizontal meridian were measured using the OCT II and the Visante TM OCT. Only total corneal thickness across the central 10mm of the horizontal meridian was measured using the Orbscan II. The order of these measurements was randomized. These measurements were repeated on Day 2. Each individual measurement was repeated three times and averaged to give a single result. Chapter 4: (2-D) Images of the edges of marketed silicone hydrogel and hydrogel lenses with refractive indices (n) ranging from 1.41-1.51 were taken placing them concave side down on a continuous surface. Five images for each lens were taken using a UHR-OCT system, operating at 1060 nm with ~3.2um (axial) and 10μm (lateral) resolution at the rate of 75,000 A-scans/s. The displacement of the glass slide beneath the lens edge was measured using Image J. Chapter 5: Thirty participants (neophytes) were included in the study and the four lenses (Acuvue Advance 8.3, Acuvue Advance 8.7, Pure Vision 8.3, and Pure Vision 8.6) were randomly assigned for each eye. The lenses were worn for a period of two weeks on a daily wear basis for 8 to 10hrs per day. Lens performance was monitored over the 2week period. Assessment of subjective comfort was made using visual analogue scales. Total corneal and epithelium thickness was measured using the Visante OCT, the lens edge profiles of the contact lenses were observed using the ultra-high resolution OCT and the conjunctival epithelial thinning was measured using the RTVue OCT. Conjunctival blood velocity was measured at the baseline and 2 week visit using a high magnification camera. Results Chapter 2: Before calibration, repeated measures ANOVA showed that there were significant differences between the mean lens thicknesses from each of the measurement methods (p<0.05), where Visante measurements were significantly different from the other three (OCT II, MG and OP) methods (p<0.05). Visante thickness was significantly higher than the microgauge measures (453±37.6 µm compared to 445.1±38.2 µm) and the OCT II was significantly lower (424.5±36.1 µm both, p<0.05). After calibration using the regression equations between the physical and optical measurements, there were no differences between OCT II and Visante OCT (p<0.05). Chapter 3: Mean central corneal and epithelial thickness using the Visante™ OCT after calibration at the apex of the cornea was 536± 27 µm (range, 563-509 µm) and 55± 2.3 µm (range, 57.3-52.7 µm), respectively. The mean corneal and epithelial thickness using OCT II at the apex was 520±25µm and 56±4.9 µm, respectively. The mean of total corneal thickness measured with the Orbscan II was 609±29µm. Visante OCT was the most repeatable for test-retest at the apex, nasal and temporal quadrants of the cornea compared to OCT II and Orbscan II. COR’s of Visante OCT ranged from ±7.71µm to ±8.98µm for total corneal thickness and ± 8.72 µm to ± 9.92 µm for epithelial thickness. CCC’s with Visante OCT were high for total corneal thickness for test-retest differences ranging from 0.97 to 0.99, CCC’s for epithelial thickness showed moderate concordance for both the instruments. Chapter 4: Results showed that artefactual displacement of the contact lens edge was observed when the lenses were imaged on the glass reference sphere, custom made rigid contact lenses (1.376) and on the conjunctival tissue. The displacement measured on the conjunctival tissue ranged from 7.0±0.86 µm for the Air Optix Night and Day to 17.4±0.22 µm for the Acuvue Advance contact lenses. The range of displacement with the soft lens edges imaged on the rigid contact lens was from 5.51±0.03 µm to 9.72±0.12 µm. Chapter 5: The lenses with the steepest sag (Acuvue Advance 8.3, Pure Vision 8.3) resulted not only with the tightest fit, but with compromise to the superior conjunctiva. This was especially seen with the Acuvue Advance lenses. The steeper lenses caused more total corneal swelling, superior epithelial thinning, mechanical compression of conjunctiva, conjunctival staining, bulbar hyperemia, conjunctival indentation and reduced blood flow at the lens edge. Not many associations were observed between baseline clinical and 2 weeks sensory variables. However, significant associations were observed when comparing the baseline clinical variables to end of the day sensory variables. Baseline clinical variables compared to 2 week clinical variables also showed significant correlations. Conclusions Chapter 2: Using reference lenses with refractive index of the cornea (1.376) allows rapid and simple calibration and cross calibration of instruments for measuring the corneal thickness. The Visante and OCT II do not produce measurements that are equal to physical references with refractive index equal to the human cornea. Chapter 3: There is good repeatability of corneal and epithelial thickness using each OCT for test-retest differences compared to the between instruments repeatability. Measurements of epithelial thickness are less repeatable compared to the total corneal thickness for the instruments used in the study. Chapter 4: When contact lenses are imaged in-situ using UHR-OCT the conjunctival tissue appeared displaced. This experiment indicates that this displacement is an artefact of all OCT imagers since a continuous surface (glass slide) was optically displaced indicating that the displacement that is observed is a function of the refractive index change and also the thickness of the contact lens edges. Chapter 5: Discomfort is a complex issue to resolve since it appears to be related to ocular factors such as the corneal and conjunctival topography and sagittal depth; to lens factors that is 1) how the sag depth of the lenses relate to the corneal/conjunctival shape and depth and therefore how well it moves on the eye. 2) Also with the lens material; whether they are high or low modulus, low or high water content, dehydration properties, wetting agents used and its resistance to deposits, lens edge profile and thickness and its interaction with the upper eyelid.