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Non-Destructive Characterization of Degradation and Drug Release Processes in Calcium Polyphosphate Bioceramics Using MRIBray, Joshua 06 December 2010 (has links)
A modern approach to the treatment of localized disease involves the use of advanced polymeric or ceramic implant materials for controlled-rate drug delivery. These implants are dynamic systems that maintain drug concentrations within the optimal therapeutic window via complex hydration, swelling, and degradation processes. To optimize the performance of these materials, however, requires a fundamental understanding of the mechanisms that govern drug release. Magnetic resonance imaging (MRI) provides a means of non-invasively characterizing the microstructure and transport properties in this type of material, and has proven to be an invaluable tool for their advancement.
Calcium polyphosphate (CPP) is a biomaterial that has shown promise as a degradable matrix for drug delivery and bone defect repair. Release rates are potentially governed by hydrogelation, swelling, and polymer chain scission. CPP bioceramics have previously been studied using models for drug elution, but these tend to be simplistic and unable to explain the many interrelated mechanisms. Structural analysis techniques have also been applied, but these tend to be inherently destructive and unable to characterize the material in situ.
With the aim of characterizing degradation/drug release mechanisms, a non-invasive approach based on MRI was developed and optimized for imaging two existing types of CPP device. Techniques included mapping of the T1 and T2 relaxation times and the apparent diffusion coefficient (ADC), which together provide sensitivity to local fluid transport parameters. The non-destructive nature of MRI permitted longitudinal observation, and structural degradation effects were investigated by correlation with concurrent drug elution measurements.
Temporal variation in the release mechanisms was treated by analyzing elution in stages. Large variation between samples was found, but on average, drug elution that was controlled by a structural-relaxation mechanism appeared correlated with the gradual formation of a highly-mobile ``free'' water component within the disk. Other characteristics, such as swelling rate, did not appear to correlate with drug release at all. While the data did not implicate a singular, governing scheme for drug release from CPP bioceramics, the approach did yield an assessment of the relative importance of the various contributing mechanisms.
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Non-Destructive Testing of Subsurface Infrastructure using Induced Polarization and Electrical Resistivity ImagingTucker, Stacey Elizabeth 16 December 2013 (has links)
As of September 2007, there were over 67,000 U.S. bridges in the National Bridge Inventory classified as having unknown foundations. The bridges spanning rivers are of critical importance due to the risks of potential scour. In fact, over half of all bridge collapses are due to scour. Not only are these failures costly, they can be deadly for the traveling public. On April 5, 1987, ten people were killed in New York when a pier collapsed on the Schoharie Creek Bridge causing two spans of the deck to fall into the creek. Several other fatal collapses have occurred since the Schoharie Creek Bridge failure. Detecting scour is only part of the assessment that must take place to determine risk of failure and knowing the foundation depth is a critical component of the assessment. While this issue is not new, current techniques are typically invasive or costly.
This research explores the feasibility and effectiveness of induced polarization (IP) and electrical resistivity imaging (ERI), near surface geophysical methods, for determining the depth of unknown foundations. In this work, forward models are created to ascertain the effects of the bridge layout on data quality such as varying depths and the impact of adjacent foundations on the foundation in question. Next, an experimental study is conducted at a National Geotechnical Experimentation Site (NGES) to further identify key parameters for the testing design and setup in order to obtain optimal surveys of bridge foundations. The conclusions of the forward modeling and NGES investigations are used to plan the field surveys on four bridges with known foundations. The outcomes of the four bridges show that IP and ERI can be used in concert with one another to estimate the type and depth of bridge foundations. The results of the field surveys are used to create a probability of non-exceedance curve for future predictions of unknown bridge foundations using the methods described in this research.
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Zonal separation and solids circulation in a draft tube fluidized bed applied to coal gasification.Rudolph, V. January 1984 (has links)
In this thesis a fluidized bed containing a draft tube has been studied with
the aim of developing the apparatus for coal gasification. The process has
the capability of producing synthesis quality gas using air for combustion,
and of being able to accomodate poor quality coal feeds containing heavy fines
loads. These advantages arise from two special features of a draft tube
fluidized bed. In the first place, the bed may be operated as two separate
and independent reaction zones, one contained within the draft tube and the
other in the annulus region surrounding it. As a result, the gasification
reactions may be carried out in one compartment and the combustion reactions
in the other, allowing the useful gasification products to be taken off
separately and undiluted with the combustion flue gases. Secondly, the
fluidized material in the bed may be induced to circulate up the draft tube
and down the annulus. These circulating solids provide the heat carrier from
the combustion to the gasification zones within the bed. Furthermore,
circulation of the bed in this way leads to a much longer residence time of
fine particles within the bed and results in a high fine coal utilization
efficiency.
In order to achieve these benefits in practice, it is necessary to separate
the gases supplied to and emitted from the draft tube from those of the
annulus, but at the same time allowing free movement of solids between these
regions.
The thesis deals with how this may be accomplished in three parts:
Firstly, the principles underlying division of a fluidized bed with a draft
tube into discrete reaction zones are formulated, and strategies for achieving
zonal separation, based on these arguments, are experimentally tested. As a
result a reactor configuration and operating conditions suitable for coal
gasification have been empirically identified.
Secondly, a model describing the bulk circulation of solid material in the bed
is presented, for the draft tube operating in the slugging mode. This model
allows the average solids residence time and the particle velocities in the
annulus and draft tube to be predicted, provided that slug velocities and
spacings are known. The necessary correlations between hydrodynamic behaviour
and the system properties are available in the literature for round nosed and
wall slugs, but not for square nosed slugs, which appear to be characteristic
in the apparatus used here.
The third part consequently examines the square nosed slugging regime, and a
theory to describe this behaviour, based on interparticle stress analysis, is
presented. This regime is identified as having significant advantage over
other bubbling modes because of the high dense phase gas flow rates which are
sustained, and the resulting improved gas-solid contacting.
The three models together mathematically describe the operation of the draft
tube fluidized bed, allowing gas partition between the annulus and the draft
tube regions as well as solids circulation to be predicted, for different bed
configurations and operating conditions. The predictions compare well with
experimental results.
The last part of the thesis deals with the application of the system to coal
gasification on a one ton coal per day pilot plant. A high quality gas,
containing up to 80% CO + H2, (balance CO2), has been produced by steam
gasification in the draft tube, using air for the combustion reaction in the
annulus. The H2/CO ratio can be varied from about 1 to 3, by changing the
operating temperature of the reactor. / Thesis (Ph.D.)-University of Natal, Durban, 1984.
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Non-contact method to measure the material properties of layered mediaStolzenburg, Jens Christian 08 1900 (has links)
No description available.
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Development of a non-destructive optical method to measure residual stress in thin rectangular samples employing digital image processingAllard, Christopher E. 05 1900 (has links)
No description available.
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Development and assessment of non-destructive evaluation techniques for the measurment of stress and strain in biological materialsCoulter, Ryan David, strain 07 June 2007 (has links)
The heterogeneous and anisotropic nature of wood material creates additional design challenges not present with the use of other structural materials such as steel and aluminum. The natural variation in the physical properties of wood members requires that the specified strengths and resistances used for design calculations be based on the quantities measured for the fifth percentile of all wood materials tested. The result is that design may be unnecessarily conservative and subsequently inefficient.
The same properties that cause uncertainty surrounding the physical properties of biological materials also create difficulty in applying non-destructive evaluation techniques. Strain measurement is one particular technique that is extremely valuable for materials of known and consistent stress-strain relationships, but whose usefulness is diminished when applied to biological materials.
To demonstrate the need for more accurate strain measurement in light-framed structures, the predictive calculations and structural modelling of a post-framed building was compared to its demonstrated performance. The analysis did not adequately reflect the actual performance of the building, and it was determined that additional monitoring of light-framed buildings through systems such as strain measurement was required to gain a better understanding of the performance characteristics in order to optimize evaluation techniques.
This project aimed to develop a system that accurately measures strain in dimensional lumber of different types, which in turn will enable researchers to enhance monitoring the performance of light-frame structures and optimize design analysis and structural modelling techniques. The development of a methodology that provides a practical means by which to perform in-situ testing of post-frame buildings and decreases the complexity of post-frame building monitoring will contribute to the advancement of design and analysis techniques.
In the calibration phase of the project, metal foil resistance strain gages were mounted onto wooden specimens with dimensions of 5 x 13 x 40 mm, 5 x 40 x 100 mm, and 2 x 20 x 50 mm, and acrylic specimens with dimensions of 3 x 25 x 75 mm. These specimens were then subjected to loading in an ATS universal testing machine in the Physical Properties Lab at the University of Manitoba. Stress-strain curves were developed based upon the observed stress and strain levels. These calibrated gages were then mounted on to a 38 x 89 mm specimen of S-P-F dimensional lumber which represented a typical light-framed building material. This assembly was then subjected to a similar loading procedure as the calibrated gage and stress-strain curves were generated once again.
The slopes of the stress-strain curves developed from the two phases of the project were compared to determine if a consistent correlation existed. The three sizes of wood specimens did not demonstrate a consistent correlation. However, the acrylic specimen demonstrated consistent correlation amongst two groups of three with correlation coefficients within a forty percent range in one group and within a nine percent range in the other group. This suggests that further experimental refinements could produce the desired results.
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Development and assessment of non-destructive evaluation techniques for the measurment of stress and strain in biological materialsCoulter, Ryan David 07 June 2007 (has links)
The heterogeneous and anisotropic nature of wood material creates additional design challenges not present with the use of other structural materials such as steel and aluminum. The natural variation in the physical properties of wood members requires that the specified strengths and resistances used for design calculations be based on the quantities measured for the fifth percentile of all wood materials tested. The result is that design may be unnecessarily conservative and subsequently inefficient.
The same properties that cause uncertainty surrounding the physical properties of biological materials also create difficulty in applying non-destructive evaluation techniques. Strain measurement is one particular technique that is extremely valuable for materials of known and consistent stress-strain relationships, but whose usefulness is diminished when applied to biological materials.
To demonstrate the need for more accurate strain measurement in light-framed structures, the predictive calculations and structural modelling of a post-framed building was compared to its demonstrated performance. The analysis did not adequately reflect the actual performance of the building, and it was determined that additional monitoring of light-framed buildings through systems such as strain measurement was required to gain a better understanding of the performance characteristics in order to optimize evaluation techniques.
This project aimed to develop a system that accurately measures strain in dimensional lumber of different types, which in turn will enable researchers to enhance monitoring the performance of light-frame structures and optimize design analysis and structural modelling techniques. The development of a methodology that provides a practical means by which to perform in-situ testing of post-frame buildings and decreases the complexity of post-frame building monitoring will contribute to the advancement of design and analysis techniques.
In the calibration phase of the project, metal foil resistance strain gages were mounted onto wooden specimens with dimensions of 5 x 13 x 40 mm, 5 x 40 x 100 mm, and 2 x 20 x 50 mm, and acrylic specimens with dimensions of 3 x 25 x 75 mm. These specimens were then subjected to loading in an ATS universal testing machine in the Physical Properties Lab at the University of Manitoba. Stress-strain curves were developed based upon the observed stress and strain levels. These calibrated gages were then mounted on to a 38 x 89 mm specimen of S-P-F dimensional lumber which represented a typical light-framed building material. This assembly was then subjected to a similar loading procedure as the calibrated gage and stress-strain curves were generated once again.
The slopes of the stress-strain curves developed from the two phases of the project were compared to determine if a consistent correlation existed. The three sizes of wood specimens did not demonstrate a consistent correlation. However, the acrylic specimen demonstrated consistent correlation amongst two groups of three with correlation coefficients within a forty percent range in one group and within a nine percent range in the other group. This suggests that further experimental refinements could produce the desired results.
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Documentation And Examination Of Historic Building Materials For The Purpose Of Conservation:case Study,part Of The Walls At The Citadel Of AnkaraTokmak, Musa 01 January 2005 (has links) (PDF)
The study aimed to identify deterioration problems, repair and conservation needs of andesites on the walls of the Ankara Castle. Decay forms of walls were documented by visual examination. Samples taken from the surface of the weathered andesites were examined for their basic physical, mechanical compositional and minerological properties. The bulk density and total porosity were determined as basic physical properties. The mechanical properties were expressed as ultrasonic velocity and modulus of elasticity (Emod). Compositional and mineralogical properties were determined by optical microscopy and XRD analyses.
Soluble salt content of the andesite samples was determined by spot tests of anions and electrical conductivity measurements.
Findings were evaluated in terms of the long-term weathering behaviour of andesites under the effect of the prevailing climate, air pollution problems of
Ankara, dampness problems of the structure, previous repairs with incompatible cement mortars.
The surfaces of Ankara Castle andesite blocks were heavily weathered. The results were compared with the physical and mechanical properties of fresh andesites from Gö / lbaSi-Ankara quarry. The surface of the andesite blocks at the Ankara Castle, had low bulk density and high porosity, low ultrasonic velocity and low Emod values. Thin section and XRD analyses supported those results by revealing the presence of physical and chemical weathering on feldspars and other main minerals of andesite, as well as the presence of amorphous minerals at the surface.
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Test and evaluation master plan for "ACTE LIS" /Choudhary, Surendra Singh. Unknown Date (has links)
Thesis (MEng in Test and Evaluation)--University of South Australia, 1995
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A critical analysis of the acoustic emmission technique for NDE of pressure vessels /Shum, Pak W., January 1992 (has links)
Thesis (M.S.)--Virginia Polytechnic Institute and State University, 1992. / Vita. Abstract. Includes bibliographical references (leaves 84-86). Also available via the Internet.
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