Spelling suggestions: "subject:"anachronic"" "subject:"inchronic""
291 |
Motility and chemotaxis studies in Helicobacter pyloriFoynes, Susan January 1999 (has links)
No description available.
|
292 |
A psychological investigation of pain processingKoutanji, Maria January 1997 (has links)
No description available.
|
293 |
Adhesion mechanisms in CLL and HCLVincent, Andrea M. January 1996 (has links)
No description available.
|
294 |
Temporal changes in a rabbit model of pulmonary fibrosisHill, Anthony Alan January 1999 (has links)
No description available.
|
295 |
Management of ventricular arrhythmias in the failing heart : a clinical studyBashir, Yaver January 1994 (has links)
No description available.
|
296 |
Renal haemodynamic reserve during pregnancy in health and diseaseSturgiss, S. N. January 1992 (has links)
No description available.
|
297 |
Analysis of the role of endothelial nitric oxide in regulating the tone and responses of pulmonary artery rings to drugsHaghighi, Masoud Kavoli January 1995 (has links)
No description available.
|
298 |
Differential expression of matrix metalloproteinases in impaired wound healing of the diabetes mouseWall, Steven J. January 2001 (has links)
No description available.
|
299 |
Giving a Voice to Adolescents Living with a Sibling with Chronic IllnessMacMullen, Jill 13 December 2013 (has links)
The purpose of this phenomenological enquiry was to gain a deeper understanding of what it means to be an adolescent living with a sibling who has a chronic illness. Children’s chronic illness has an impact on well siblings and research findings have been inconsistent as to what effect this has on them. Semi-structured interviews using photo-elicitation were conducted with eight adolescents who had siblings with a chronic illness. Through the use of interpretive phenomenology, three themes emerged: Making Sense over Time, Getting Away from It All, and Creating Common Ground with Siblings and Family. The adolescents were able to make sense of chronic illness over time by asking parents questions about the illness and attending support groups. Siblings found normalcy in their lives by getting away to spend time alone or connecting with friends.
|
300 |
NanoAPC deliver antigen, IL-2 and co-stimulatory molecules to antigen specific T cells and activate viral specific T cells in chronic infectionsLiu, Mengya January 2011 (has links)
The study of the immune system has provided insight in the mechanism of protection induced by vaccination; primarily that most clinically protective vaccines are potent in generating neutralizing antibody responses. However, vaccination fails to protect against a wide range of acquired chronic infections caused by viruses, such as HIV, HBV and HCV. One of the major reasons for weak responses to therapeutic vaccine is the impaired function of effector T cells resulting from viral persistence. Although IL-2 can potently increase effect function of viral specific T cells, systemic administration of IL-2 induces organ pathology and expansion of Treg cells. In this study, we have now developed a novel vaccine delivery system IL-2-nanoAPC delivering antigen-MHC complexes (pMHC), co-stimulatory molecules and IL-2 to antigen specific T cells. NanoAPC are derived from the endoplasmic reticulum (ER) membranes of human B cell line 721.221 engineered with selected HLA allele and IL-2 as the ER retention proteins. The IL-2-nanoAPC interacted with antigen specific T cells, induced immune synapses and expression of high affinity IL-2 receptor and enhanced effector function of antigen specific T cells, but did not affect bystander T cells and Foxp3+ Treg cells. Together with pMHC, co-stimulatory molecules, the selective delivery of IL-2 not only increased the CD4 and CD8 T cell responses to viral antigens but also enhanced TCR proximal signalling and suppressed expression of PD1 molecules on IFNγ producing effector CD8 T cells. We also found that the co-induction of T helper responses by IL-2-nanoAPC in a mixed culture could increase CD8 T cell responses to viral antigen. The IL-2-nanoAPC effectively induced responses of CD4 and CD8 T cells from chronic HBV patients. The results demonstrate that selective delivery of IL-2, together with pMHC and co-stimulatory molecules, by nanoAPC to antigen specific T cells has potential to recover anti-viral immune responses in chronic HBV patients.
|
Page generated in 0.0616 seconds