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Spectral studies on thymine deoxyribopolynucleotidesChandler, Bruce Stanford January 1970 (has links)
248 leaves : ill. / Title page, contents and abstract only. The complete thesis in print form is available from the University Library. / Thesis (Ph.D.1971) from the Dept. of Physical and Inorganic Chemistry, University of Adelaide
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Spectral studies on thymine deoxyribopolynucleotides.Chandler, Bruce Stanford. January 1970 (has links) (PDF)
Thesis (Ph.D. 1971) from the Dept. of Physical and Inorganic Chemistry, University of Adelaide.
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Synthetic polynucleotides studies on poly (dG-dC). poly (dG-dC), poly (dI-dC). poly (dI-dC) and poly (A-U). poly (A-U) /Grant, Robert Charles, January 1971 (has links)
Thesis (Ph. D.)--University of Wisconsin--Madison, 1971. / Typescript. eContent provider-neutral record in process. Description based on print version record. Includes bibliography.
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Synthetic studies of carbocyclic nucleosides. / CUHK electronic theses & dissertations collectionJanuary 2012 (has links)
本文描述了以D-核糖為起始原料,通過分子內的Diels-Alder (IMDA) 反應來構建雙碳環,以及其在雙碳環核苷合成方面的研究。 / D-核糖 (20) 經丙酮化,乙烯化作用和乙二醇裂解反應 (在硅膠的輔助作用下)可以得到乳醇68。本文考察了通過不同的方法來合成關鍵中間體三烯65。三烯中間體 65 經氧化和環化,最終可以合成出雙環[4. 3. 0]壬烷結構的碳環物64。由D-核糖為起始原料,只需6 步驟就可以得到碳環物64[附圖]。 / 為了引入C -5'的羥基,進行了環氧化和環氧化物還原反應的研究。由碳環物64 開始通過10 至15 步,可以合成出一系列含新型的[4. 3. 0]結構碳環核苷59-62[附圖]。 / 以疊氮化炔的Huisgen 環加成反應(點擊化學)作為關鍵步,合成出一系列含新型的[4. 3. 0]結構碳環核苷利巴韋林類似物[附圖]。 / In this thesis, the construction of bicyclic carbocycle from D-Ribose via an intramolecular Diels Alder (IMDA) reaction and its application to the syntheses of carbobicyclic nucleosides are presented. / D-Ribose (20) underwent acetonation, vinylation, mild silica gel supported glycol cleavage to give the lactol 68. Different methods were studied in the synthesis of the key triene intermediate 65. Oxidation of the triene intermediate and employing IMDA reaction finally afforded the bicyclo[4.3.0]nonane framework carbocycle 64 in 6 steps from D-Ribose [With images]. / To install the C-5’ hydroxyl group, epoxidation and epoxide reduction reactions were studied and reported. A series of carbobicyclic nucleosides 59-62 with a novel bicyclo[4.3.0]nonane framework were synthesized from cycloadduct 64 in 10 to 15 steps [With images]. / The syntheses of a series of carbobicyclic ribavirin analogues with bicyclo[4.3.0]nonane framework using azide alkyne Huisgen cycloaddition (Click Chemistry) as the key step were also studied and reported [With images]. / Detailed summary in vernacular field only. / Detailed summary in vernacular field only. / Detailed summary in vernacular field only. / Detailed summary in vernacular field only. / Wong, Wing Ho Anthony. / Thesis (Ph.D.)--Chinese University of Hong Kong, 2012. / Includes bibliographical references (leaves 175-185). / Electronic reproduction. Hong Kong : Chinese University of Hong Kong, [2012] System requirements: Adobe Acrobat Reader. Available via World Wide Web. / Abstract also in Chinese. / Acknowledgment --- p.i / Table of Contents --- p.ii / Abstract --- p.iv / Abstract (Chinese Version) --- p.vi / Abbreviation --- p.vii / Chapter 1 --- Introduction --- p.1 / Chapter 1.1 --- General Background --- p.1 / Chapter 1.2 --- Conformation of nucleosides --- p.3 / Chapter 1.2.1 --- Conformation of conventional nucleosides --- p.3 / Chapter 1.2.2 --- Conformation of carbocyclic nucleosides --- p.7 / Chapter 1.3 --- Previous syntheses and development of conformationally locked carbocyclic nucleosides --- p.9 / Chapter 1.3.1 --- Synthesis of dideoxyribonucleosides in N conformation --- p.9 / Chapter 1.3.2 --- First enantioselective synthesis of 2’-Deoxyribonucleosides Analogues with N conformation --- p.10 / Chapter 1.3.3 --- Most recent synthesis of bicyclo[3.1.0]hexane system ribonucleoside analogue --- p.12 / Chapter 1.3.4 --- Synthesis of bicyclo[3.3.0]octane system carbocyclic nucleosides --- p.13 / Chapter 1.3.5 --- Synthesis of nucleosides with bicyclo[2.2.1]heptene/heptanes skeleton --- p.16 / Chapter 1.3.6 --- Synthesis of spirocarbocyclic nucleosides --- p.18 / Chapter 2 --- Results and Discussion --- p.20 / Chapter 2.1 --- Construction of Bicyclic Carbocycle via Intramolecular Diels-Alder Reaction (IMDA) --- p.20 / Chapter 2.1.1 --- Synthesis of triene precusor and the bicyclo[4.3.0]nonane framework --- p.21 / Chapter 2.1.2 --- Synthesis of triene precusor and the bicyclo[4.3.0]nonane framework using open chain approach --- p.27 / Chapter 2.1.3 --- Synthesis of triene precusor by the use of Wittig Reaction --- p.29 / Chapter 2.2 --- Attempted epimerization of C-6 position of the cycloadduct --- p.40 / Chapter 2.2.1 --- Attempted epimerization of cycloadduct 64 --- p.40 / Chapter 2.2.2 --- Attempted epimerization of saturated ketone 84 --- p.41 / Chapter 2.2.3 --- Attempted epimerization of diols 86 and 88 --- p.42 / Chapter 2.2.4 --- Attempted epimerize of dibenzyl ether 90 --- p.45 / Chapter 2.3 --- Synthesis of the target nucleosides --- p.47 / Chapter 2.3.1 --- Synthesis of alcohol 106 and 107 --- p.47 / Chapter 2.3.2 --- Attempted synthesis of target nucleosides by convergent method --- p.57 / Chapter 2.3.3 --- Synthesis of adenosine analogue 59 via linear methods --- p.62 / Chapter 2.3.4 --- Synthesis of thymidine analogue 60 and uridine analogue 61 --- p.68 / Chapter 2.3.5 --- Synthesis of citidine analogue 62 --- p.70 / Chapter 2.3.4 --- Attempted synthesis of guanosine analogue 63 --- p.75 / Chapter 2.4 --- Syntheses of ribavirin analogues by Click Chemistry --- p.78 / Chapter 2.4.1 --- Synthesis of 5’-deoxyribavirin analogues --- p.78 / Chapter 2.4.2 --- Synthesis of ribavirin analogues --- p.84 / Chapter 3 --- Conclusion --- p.89 / Chapter 4 --- Experimental Section --- p.95 / Chapter 5 --- References --- p.175 / Chapter 6 --- Appendix --- p.186 / X-ray crystallographic data and structures --- p.189 / NMR spectra --- p.207
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The synthesis of nucleoside and silyl nucleotide analogues /Cormier, James January 1987 (has links)
No description available.
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Control of pyridine nucleotides in tissuesCaiger, Philip. January 1964 (has links) (PDF)
Typescript Includes bibliographical references Specific enzymic assays by direct spectrophotometry for both the oxidized and reduced forms of nicotinamide-adenine dinucleotide and of nicotinamide-adenine dinucleotide phosphate are described.
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The effect of gibberellic acid on free nucleotide metabolism in aleurone cells of wheatCollins, Graham G. January 1970 (has links) (PDF)
No description available.
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Evolution mechanisms and biological significance of CG dinucleotide compositional bias in genomesWang, Yong, 王勇 January 2003 (has links)
published_or_final_version / abstract / toc / Zoology / Doctoral / Doctor of Philosophy
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The synthesis of nucleoside and silyl nucleotide analogues /Cormier, James January 1987 (has links)
A route to the synthesis of arabino and xylonucleosides is described. This route takes advantage of highly selective ribonucleoside hydroxyl protection procedures which have recently been developed. The route is straightforward and broadly applicable. It may be applied to both purine and pyrimidine nucleosides. Synthesis, deprotection, and characterisation of the target compounds are described. The work is compared to that of others in the field. / A novel class of oligonucleotide analogues is described. In this group, the phosphorus atom of the internucleotide link is replaced by silicon. The synthesis of both oligothymidine and oligo-2$ sp prime$-deoxyadenosine nucleotide analogues of this class is described. Various substituents at silicon are employed, and oligonucleotide analogs of up to six units long are synthesised, characterised and deprotected. The circular dichroism spectra of the deprotected hexamers is presented.
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Synthesis and properties of novel nucleoside and nucleotide analogues : a thesisGillen, Michael Francis. January 1980 (has links)
The synthesis of novel nucleoside and nucleotide analogues in which the sugar moiety is replaced by an aliphatic chain is described. The acyclic analogue of adenosine was tested as both a substrate and an inhibitor of adenosine deaminase while the interaction of some dinucleoside monophosphate analogues with spleen and snake venom phosphodiesterase is reported. Some mention is made of the solution conformation of these acyclic derivatives. / The utility of the methyl group as a phosphate protecting group in oligonucleotide synthesis was reinvestigated and the preparation of some interesting 2', 5' linked trinucleoside diphosphate analogues of adenosine, with the methyl moiety as phosphate masking group, was undertaken. A novel approach to the cleavage of phosphate methyl esters is discussed. / A facile fluoride ion mediated preparation of alkylated nucleoside base fragments was discovered. This procedure led to high isolated yields of a variety of N-alkylated purines and pyrimidines.
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