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201	A Systematic Review, Meta-Analysis and Meta-Regression of the Proportion of Campylobacter, Non- typhoidal Salmonella and E. coli O157 Cases that Develop Chronic Sequelae Keithlin, Jessica 03 January 2013 (has links) Understanding of chronic sequelae development after infection with foodborne pathogens is limited and an increased understanding could assist with the development of more accurate burden of disease estimates. The purpose of this thesis was to determine via systematic review and meta-analysis of the published international literature, the proportion of cases of Salmonella, Campylobacter and E. coli O157 that will develop the chronic sequelae of reactive arthritis, haemolytic uraemic syndrome, irritable bowel syndrome, inflammatory bowel disease or Guillain Barré syndrome. This information can be used to increase our understanding of the relationship between infection and the development of long term health complications while providing a key piece of information for the development of accurate burden of disease estimates. / Canadian Institutes of Health Research Institute of Population and Public Health/Public Health Agency of Canada, Applied Public Health Research Chair (awarded to Jan M. Sargeant) foodborne disease non-typhoidal salmonella E. coli O157 E. coli Campylobacter Salmonella HUS Reactive Arthritis IBS Irritable Bowel Syndrome IBD Inflammatory Bowel Disease Guillain Barre Syndrome GBS chronic sequelae sequelae systematic review meta-analysis meta-regression
202	Influence of pathogenic bacterial determinants on genome stability of exposed intestinal cells and of distal liver and spleen cells Walz, Paul S January 2011 (has links) Most bacterial infections can be correlated to contamination of consumables such as food and water. Upon contamination, boil water advisories have been ordered to ensure water is safe to consume, despite the evidence that heat-killed bacteria can induce genomic instability of exposed (intestine) and distal cells (liver and spleen). We hypothesize that exposure to components of heat-killed Escherichia coli O157:H7 will induce genomic instability within animal cells directly and indirectly exposed to these determinants. Mice were exposed to various components of dead bacteria such as DNA, RNA, protein or LPS as well as to whole heat-killed bacteria via drinking water. Here, we report that exposure to whole heat-killed bacteria and LPS resulted in significant alterations in the steady state RNA levels and in the levels of proteins involved in proliferation, DNA repair and DNA methylation. Exposure to whole heat-killed bacteria and their LPS components also leads to increased levels of DNA damage. / xiv, 132 leaves : ill. (chiefly col.) ; 29 cm Escherichia coli O157:H7 -- Research Microbial carcinogenesis -- Research DNA damage -- Research Intestines -- Infections -- Pathogenesis Liver cells Spleen -- Pathogenesis -- Research Endotoxins -- Research Mice as laboratory animals Dissertations, Academic

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A Systematic Review, Meta-Analysis and Meta-Regression of the Proportion of Campylobacter, Non- typhoidal Salmonella and E. coli O157 Cases that Develop Chronic Sequelae

Influence of pathogenic bacterial determinants on genome stability of exposed intestinal cells and of distal liver and spleen cells