As societies evolve, offices have become the places were the majority of working activities take place. Occupants’ comfort in office buildings has always been a very important issue in the building sector and therefore guidelines regarding indoor comfort standards have been developed throughout the years. Nevertheless, there is a need for investments on new and innovative ideas which will go beyond the existing guidelines and move towards a more sustainable and human oriented office environment.The present thesis aims at promoting this idea of sustainable offices by developing and presenting an innovative technological method which will provide the opportunity to measure the office workers’ perceived comfort in real time. This in its turn will enable the building sector stakeholders to operate office buildings in a more sustainable way in terms of building services provision to their occupants.In order to achieve these objectives, the first part of the thesis is dedicated in describing the basic indoor environmental components of the office environment as well as the possible associations between improved indoor environmental quality and occupants’ health, wellbeing and productivity. The second part aims to provide a detailed presentation of the existing or emerging methods which are currently used in order to predict or directly measure occupants’ perceived comfort in office places while in the same time discussing their current capabilities and limitations. In the final part, our proposed method, which could be used for the purposes of real time perceived comfort measurements, is presented. This proposed method includes four different steps which are separately presented with detailed instructions regarding their proper implementation.