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  • About
  • The Global ETD Search service is a free service for researchers to find electronic theses and dissertations. This service is provided by the Networked Digital Library of Theses and Dissertations.
    Our metadata is collected from universities around the world. If you manage a university/consortium/country archive and want to be added, details can be found on the NDLTD website.
21

The prognostic significance of DJ-1 in patients with renal cell carcinoma of clear cell type

Lee, Wing-sang. January 2009 (has links)
Thesis (M. Med. Sc.)--University of Hong Kong, 2009. / Includes bibliographical references (p. 67-76).
22

Screening of a rat thymus and a human hippocampus cDNA library for a novel fyn-related oncogene

Collins-De Peyer, Laurence. January 1999 (has links)
published_or_final_version / Zoology / Master / Master of Philosophy
23

A study of p53 in epithelial ovarian cancer

Fallows, Sarah Aileen Sharon January 1998 (has links)
No description available.
24

An examination of the BCR-ABL oncogene as a precise indicator of treatment response, drug resistance and relapse in patients with chronic myeloid leukaemia /

Branford, Susan. Unknown Date (has links)
This thesis is submitted as a PhD by Portfolio of Publications. It represents an integrated examination of the BCR-ABL oncogene as a precise indicator of treatment response, drug resistance and relapse in patients with chronic myeloid leukaemia (CML). / Thesis (PhDBiomedicalScience)--University of South Australia, 2005.
25

Isolation and characterisation of inhibitors of leukaemia with translocatins involving the mixed lineage leukaemia oncogene

Kwek, Chin Kiat, Women's & Children's Health, Faculty of Medicine, UNSW January 2007 (has links)
Acute lymphoblastic leukaemia is the most common childhood cancer with cure rates of approximately 80%. This success can be attributed to the introduction of risk stratification for patients and employment of intensified treatment regimes for patients with high risk disease. However, the identification of prognostically important leukaemia subtypes, unfortunately, is an labour-intensive process. In addition, despite the success in treating childhood ALL, specific subgroups of patients nevertheless still have poor survival rates. This is particularly true for leukaemias characterised by chromosomal translocations involving the MLL oncogene on chromosome 11q23. By using a novel bioinformatics approach, GeneRave, a set of 12 classifier genes (PTPRK, FOS, ENG, Lgal-S1, TCFL5, LRMP, CTGF, IGJ, MX1, PENK, CD3D and HBG1) was selected from a publicly available U95 Affymetrix microarray dataset. Real time PCR carried out on a blinded cohort of 58 primary ALL samples yielded an accuracy of 86%. The absence of PENK gene expression in the majority of ALL samples tested appears to have decreased the overall accuracy. Nevertheless, the results indicate that this method of classification can be easily and quickly performed and therefore may be useful as an adjunct to routinely used methodology in the diagnostic classification of childhood ALL. Parellal screening of a 34,000 chemical small molecules library identified 30 ???hits??? that exhibited specificity toward leukaemia, and many of which shared structural similarity. The cytotoxic effect of these compounds was further investigated in a panel of 19 cell lines that included 3 MLL-translocated (MV411, THP-1 and PER-485), 7 non-MLL-translocated leukaemias (REH, Jurkat, K562, HL60, Hal-01, UOB-B, NB4), 2 immortalized normal blood cell lines, 4 non-leukaemic tumour cell lines (Calu6, MCF7, BE(2)-C, and HeLa) and 3 normal cell lines (HSF, MCF10a and MRC5). In particular, two compounds were identified, SM6 and SM7, that were highly effective at killing MLL-translocated cell lines in the low micromolar range while having little or no effect on the other cell lines. Treatment of PER-485 cells with SM6 and SM7 showed mark down-regulation of the MLL chimaeric fusion protein together with its down-stream targets. One other more broadly acting anti-leukaemia compounds were also identified.
26

The individual and co-operative effects of oncogenes myb and kit in murine haemopoietic cells / Petranel Ferrao.

Ferrao, P. January 1997 (has links)
Appendix on leaves 193-197. / Additional notes pasted on back fly-leaf. / Copies of authors previously published articles in pocket inside back cover. / Bibliography: leaves 147-192. / 197, [114] leaves of plates : ill. (some col.) ; 30 cm. / Title page, contents and abstract only. The complete thesis in print form is available from the University Library. / Enforced-expression of various forms of Myb and Kit in primary murine haemopoietic cells were investigated to determine the functions of these two oncoproteins separately and in synergy in vitro. / Thesis (Ph.D.)--University of Adelaide, Dept. of Microbiology and Immunology, 1998?
27

Activating point mutations in the common ?gb?s[beta]-subunit of the human GM-CSF, IL-3 and IL-5 receptors : implications for receptor function and role in disease / by Brendan John Jenkins.

Jenkins, Brendan John January 1998 (has links)
Includes bibliographical references (17 leaves) / vii, 113, [89] leaves, [32] leaves of plates : ill. (some col.) ; 30 cm. / Title page, contents and abstract only. The complete thesis in print form is available from the University Library. / Generates and exploits activating point mutations in the common ?gb?s subunit (h?gb?sc) of the human GM-CSF, IL-3 and IL-5 receptors. Elucidates the mechanisms by which the isolated mutations confer constitutive activity on h?gb?sc. Identifies the putative all-specific signalling molecules and provides a map of the locations of activating point mutations in h?gb?sc, / Thesis (Ph.D.)--University of Adelaide, Dept. of Medicine, 1998
28

Activating point mutations in the common ?gb?s[beta]-subunit of the human GM-CSF, IL-3 and IL-5 receptors : implications for receptor function and role in disease / by Brendan John Jenkins.

Jenkins, Brendan John January 1998 (has links)
Includes bibliographical references (17 leaves) / vii, 113, [89] leaves, [32] leaves of plates : ill. (some col.) ; 30 cm. / Title page, contents and abstract only. The complete thesis in print form is available from the University Library. / Generates and exploits activating point mutations in the common ?gb?s subunit (h?gb?sc) of the human GM-CSF, IL-3 and IL-5 receptors. Elucidates the mechanisms by which the isolated mutations confer constitutive activity on h?gb?sc. Identifies the putative all-specific signalling molecules and provides a map of the locations of activating point mutations in h?gb?sc, / Thesis (Ph.D.)--University of Adelaide, Dept. of Medicine, 1998
29

Activating point mutations in the common?gb?s[beta]-subunit of the human GM-CSF, IL-3 and IL-5 receptors : implications for receptor function and role in disease /

Jenkins, Brendan John. January 1998 (has links) (PDF)
Thesis (Ph. D.)--University of Adelaide, Dept. of Medicine, 1998. / Includes bibliographical references (17 leaves ).
30

Molecular analysis of the ewings sarcoma oncogene transcriptional activation domain /

Feng, Liang. January 2002 (has links)
Thesis (M. Phil.)--Hong Kong University of Science and Technology, 2002. / Includes bibliographical references (leaves 74-85). Also available in electronic version. Access restricted to campus users.

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