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  • About
  • The Global ETD Search service is a free service for researchers to find electronic theses and dissertations. This service is provided by the Networked Digital Library of Theses and Dissertations.
    Our metadata is collected from universities around the world. If you manage a university/consortium/country archive and want to be added, details can be found on the NDLTD website.
11

Establishment and characterization of human ovarian surface epithelialcells immortalized by human papilloma viral oncogenes

溫錫剛, Wan, Shek-kong, Thomas. January 1997 (has links)
published_or_final_version / Anatomy / Doctoral / Doctor of Philosophy
12

The prognostic significance of DJ-1 in patients with renal cell carcinoma of clear cell type

Lee, Wing-sang., 李榮生. January 2009 (has links)
published_or_final_version / Pathology / Master / Master of Medical Sciences
13

An investigation of the functions of the c-Myc oncoprotein

Littlewood, Trevor David January 1993 (has links)
No description available.
14

Design, synthesis and evaluation of a sequence-selective DNA cleaving agent based on the pyrrolo[2,1-c][1,4]benzodiazepine ring system : investigation of the DNA-reactive species

Morris, Stephen James January 1992 (has links)
No description available.
15

Cell cycle regulation of B-myb transcription

Bennett, Julie Denise January 1996 (has links)
No description available.
16

Transcriptional transactivation properties of the human MDM2 oncoprotein

Bladen, Catherine Louise January 2000 (has links)
No description available.
17

Growth factor receptor regulation in the C2 cell system

England, Karen January 1997 (has links)
No description available.
18

Isolation and characterisation of inhibitors of leukaemia with translocatins involving the mixed lineage leukaemia oncogene

Kwek, Chin Kiat, Women's & Children's Health, Faculty of Medicine, UNSW January 2007 (has links)
Acute lymphoblastic leukaemia is the most common childhood cancer with cure rates of approximately 80%. This success can be attributed to the introduction of risk stratification for patients and employment of intensified treatment regimes for patients with high risk disease. However, the identification of prognostically important leukaemia subtypes, unfortunately, is an labour-intensive process. In addition, despite the success in treating childhood ALL, specific subgroups of patients nevertheless still have poor survival rates. This is particularly true for leukaemias characterised by chromosomal translocations involving the MLL oncogene on chromosome 11q23. By using a novel bioinformatics approach, GeneRave, a set of 12 classifier genes (PTPRK, FOS, ENG, Lgal-S1, TCFL5, LRMP, CTGF, IGJ, MX1, PENK, CD3D and HBG1) was selected from a publicly available U95 Affymetrix microarray dataset. Real time PCR carried out on a blinded cohort of 58 primary ALL samples yielded an accuracy of 86%. The absence of PENK gene expression in the majority of ALL samples tested appears to have decreased the overall accuracy. Nevertheless, the results indicate that this method of classification can be easily and quickly performed and therefore may be useful as an adjunct to routinely used methodology in the diagnostic classification of childhood ALL. Parellal screening of a 34,000 chemical small molecules library identified 30 ???hits??? that exhibited specificity toward leukaemia, and many of which shared structural similarity. The cytotoxic effect of these compounds was further investigated in a panel of 19 cell lines that included 3 MLL-translocated (MV411, THP-1 and PER-485), 7 non-MLL-translocated leukaemias (REH, Jurkat, K562, HL60, Hal-01, UOB-B, NB4), 2 immortalized normal blood cell lines, 4 non-leukaemic tumour cell lines (Calu6, MCF7, BE(2)-C, and HeLa) and 3 normal cell lines (HSF, MCF10a and MRC5). In particular, two compounds were identified, SM6 and SM7, that were highly effective at killing MLL-translocated cell lines in the low micromolar range while having little or no effect on the other cell lines. Treatment of PER-485 cells with SM6 and SM7 showed mark down-regulation of the MLL chimaeric fusion protein together with its down-stream targets. One other more broadly acting anti-leukaemia compounds were also identified.
19

Functional studies of SEI-1 and eIF5A2 candidate oncogenes isolated from frequently amplified regions of ovarian carcinomas /

Tang, Dongjiang. January 2006 (has links)
Thesis (Ph. D.)--University of Hong Kong, 2006. / Title proper from title frame. Also available in printed format.
20

Functional studies of SEI-1 and eIF5A2 : candidate oncogenes isolated from frequently amplified regions of ovarian carcinomas /

Tang, Dongjiang. January 2006 (has links)
Thesis (Ph. D.)--University of Hong Kong, 2006. / Also available online.

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