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1	Development of Peptide Cyclization Strategies for Their Incorporation into One-Bead-One-Compound Peptide Libraries Blair, Lauren Elizabeth January 2015 (has links) Thesis advisor: Jianmin Gao / Thesis advisor: Eranthie Weerapana / Cyclic peptides provide a privileged scaffold when optimizing interactions with various biological targets. Their rigidified structure decreases the entropic cost of binding by preorganizing residues in a fixed conformation, which may enhance binding affinity. These molecules occupy a larger chemical space than typical small molecule drugs and may provide good candidates for inhibiting protein-protein interactions or being able to interact with previously undruggable targets. Given the benefits of these structures we aim to develop a one-bead-one-compound peptide library for screening against relevant biological targets. Herein we describe several routes to achieving cyclic peptides through side chain interactions and head-to tail amide bond linkages. Additional considerations for the development of the on resin library such as linker strategies and sequencing methods will be discussed. / Thesis (MS) — Boston College, 2015. / Submitted to: Boston College. Graduate School of Arts and Sciences. / Discipline: Chemistry. One-Bead-One-Compound Peptide Peptide cyclization Peptide Library
2	PROFILING THE SUBSTRATE SPECIFICITY OF PROTEIN TYROSINE PHOSPHATASES BY COMBINATORIAL LIBRARY SCREENING Chen, Xianwen 20 October 2011 (has links) No description available. Biochemistry Protein tyrosine phosphatases One-bead-one-compound peptide library enzyme kinetics
3	Emerging Therapeutics for Organophosphorus Nerve Agent Poisonings. The Development of a Fluoride Ion Battery System Utilizing Nanoparticles. McKenney, Ryan Kenneth 28 July 2017 (has links) No description available. Chemistry Organophosphorus Nerve Agents Treatments for Nerve Agents Exposures Nanoparticles Fluoride Ion Battery Organic Chemistry Cyclic Peptides Organometallics Acetylcholinesterase Acetylcholine Haptens One-Bead-One-Compound Library
4	Binding Specificity of SH2 Domains Revealed by a Combinatorial Peptide Library Kunys, Andrew Richard 27 September 2013 (has links) No description available. Biochemistry Bioinformatics Biology Chemistry
5	Synthesis and screening of support-bound combinatorial cyclic peptide and free C-terminal peptide libraries Joo, Sang Hoon 10 December 2007 (has links) No description available. Chemistry, Biochemistry One-bead One-Compound (OBOC) partial Edman degradation split-and-pool synthesis cyclic peptides Free C-terminal peptide library PDZ domain
6	Development Of Cyclic Peptidyl Ligands Through A Combinatorial Library Approach Liu, Tao 27 July 2011 (has links) No description available. Biochemistry Biomedical Research Chemistry Cyclic Peptides Combinatorial Chemistry One-Bead-One-Compound (OBOC) Library Prolactin Recepotr Pin1 HIV Capsid Calcineurin Cell Penetrating Peptide (CPP)

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