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Effects of Chemotherapy on Motivated Behavior and Opioid Reward in RatsLegakis, Luke P 01 January 2018 (has links)
Paclitaxel, vincristine, oxaliplatin, and bortezomib are cancer chemotherapy drugs with adverse effects that include chemotherapy-induced neuropathic pain (CINP) as well as depression of behavior and mood. In the clinical setting, opioids are often used concurrently with or following chemotherapy to treat pain related to the cancer or CINP, but repeated opioid exposure can also increase the risk of opioid abuse. This dissertation evaluated the effect of chemotherapy treatment on motivated behaviors and opioid reward in rats. The main findings of this evaluation are as follows: (1) Chemotherapy, at doses that produce robust and sustained mechanical hypersensitivity produce only weak or nonexistent depression of positively reinforced operant responding maintained either by electrical brain stimulation in an assay of intracranial self-stimulation or by food pellets in an assay of food-maintained responding. (2) There was no correlation between the expression of mechanical hypersensitivity and depression of motivated behaviors across individual animals, suggesting that these two effects of chemotherapy do not share common mechanisms of action. (3) Mechanical hypersensitivity, but not behavioral depression could be reversed with morphine. (4) The class of chemotherapeutic used in preclinical models is a determinant of the severity of effects on neuropathy-related endpoints and on the time course of these effects. (5) Chemotherapy does not protect against the rewarding effects of repeated morphine administration and does not alter the time course of the enhancement of reward with repeated morphine exposure. These findings suggest that administration of chemotherapy to rats induces mechanical hypersensitivity while failing to decrease behaviors dependent on mesolimbic dopamine signaling or protecting against morphine abuse-related effects. While apparent that chemotherapy can produce peripheral neuropathy, the data in this dissertation does not support the hypothesis that chemotherapy can produce behavioral depressant manifestations of chemotherapy-induced neuropathic pain (CINP) in rats.
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The effect of an intervention program on cohesion with ninth grade female basketball teamsSmith, Joseph W. 25 July 1996 (has links)
The purpose of this study was to determine if team cohesion could be enhanced
for 9th grade female basketball teams with the implementation of a 14-week
intervention program. The intervention program was designed from cohesion
building strategies proposed in the literature with the help of three coaches and a
leading sport psychologist in the field of cohesion. 41 ninth grade female
basketball players belonging to four teams participated in the study. The Group
Environment Questionnaire was used to measure cohesion. It was administered
on the third week of the season and again at the end. The data were analyzed
using both the individual and the team as the unit of analysis. The findings
varied according to which unit of analysis was used. When the team was used,
no posttest differences were found, however, the effect sizes suggested that the
intervention was effective for the task subscales of the GEQ. A lack of
statistical power for the team analysis greatly reduced the probability of finding
that the meaningful differences were statistically significant. When the
individual was used, the intervention was found to be statistically detrimental
for the task subscales. The effect sizes supported this finding. The qualitative
data that was collected suggested that the coaches believed the intervention had
practical utility, and was effective. While this study did not empirically show
that the intervention was effective, it did demonstrate that the intervention is
practical enough to implement. Furthermore, the qualitative data and the effect
sizes for the team analysis provide some evidence that the intervention may have
been effective for the task dimension of team cohesion. Therefore this study
produced an intervention that can be used as a starting point for future cohesion
building investigations. / Graduation date: 1997
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Short term substance abuse intervention via equine assisted psychotherapyKimberl, Elizabeth. January 2002 (has links)
Thesis (M.A.)--Denver Seminary, 2002. / Includes bibliographical references (leaves 52-62).
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THE MOTOR BEHAVIOR CHARACTERISTICS OF CHILDREN WITH OPERANT LANGUAGE DISORDERWeber, Marylou Adam, 1935- January 1966 (has links)
No description available.
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The relation between preference and demand in the domestic hen does preference vary with price? /Bruce, Julie-Anne Marie. January 2007 (has links)
Thesis (M.App.Psy.)--University of Waikato, 2007. / Title from PDF cover (viewed March 19, 2008) Includes bibliographical references (p. 60-63)
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Physical activity intervention in early care and education settingsQiu, Wei. January 2009 (has links)
Thesis (Ph.D.)--University of Delaware, 2008. / Principal faculty advisor: Penny L. Deiner, Dept. of Human Development and Family Studies. Includes bibliographical references.
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Can happiness be taught? : the effects on subjective wellbeing of attending a course in positive psychology that includes the practice of multiple interventions : a thesis submitted in partial fulfilment of the requirements for the degree of Master of Science in Psychology in the University of Canterbury /Ogier-Price, Alison. January 2007 (has links)
Thesis (M.S.)--University of Canterbury, 2007. / Typescript (photocopy). Includes bibliographical references (leaves 79-89). Also available via the World Wide Web.
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Acquaintance rape and male high school students can a social norms intervention change attitudes and perceived norms? /Hillenbrand-Gunn, Theresa L., January 2004 (has links)
Thesis (Ph. D.)--University of Missouri-Columbia, 2004. / Typescript. Vita. Includes bibliographical references (leaves 69-77). Also available on the Internet.
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A meta-analytic examination of decisional balance across stage transitions : a cross-sectional analysis and cross-sequential cross-validation /Hall, Kara L. January 2004 (has links)
Thesis (Ph. D.)--University of Rhode Island, 2004. / Typescript. Includes bibliographical references (leaves v. 2, 389-428).
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Acquaintance rape and male high school students : can a social norms intervention change attitudes and perceived norms? /Hillenbrand-Gunn, Theresa L., January 2004 (has links)
Thesis (Ph. D.)--University of Missouri-Columbia, 2004. / Typescript. Vita. Includes bibliographical references (leaves 69-77). Also available on the Internet.
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