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En face OCT imaging for the assessment of glaucomaCheloni, Riccardo January 2021 (has links)
Glaucoma is a leading cause of irreversible vision loss globally, and demands
early and accurate diagnosis. OCT has become a key investigative technique
in glaucoma, and, although it provides invaluable clinical support, detection of
early glaucoma remains imperfect. Recent OCT developments enabled direct
assessment of retinal nerve fibre bundle (RNFB) reflectance in en face OCT
images. The technique has considerable potential in the assessment of
glaucoma, yet it has limited clinical usability due to an incomplete
understanding of RNFB features in healthy and glaucoma eyes and the lack
of accepted methods to identify reflectance defects. This thesis aimed to better
understand characteristics of RNFB reflectance in en face OCT imaging and
to develop objective methods to extract defects in this domain.
Structural and functional measures of glaucoma changes were collected in
eyes with established glaucoma and age-similar controls. Results showed that
the healthy configuration of RNFB varies across the retina and between
different eyes. We developed a method for automated and objective
examination of reflectivity changes in en face images. This method considers
individual anatomy and varying RNFB configuration, and found more
abnormalities than previous approaches. Measures of en face reflectance and
conventional retinal nerve fibre layer thickness were strongly related. The
agreement between changes of reflectance and visual function was
moderate-to-good, and both testing domains presented concordant abnormalities
in all tested eyes.
Following further minimisation of artefacts in en face images, direct use of
reflectance analysis or its combination with perimetry appear viable and with
significant potential for clinical examination of glaucoma.
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Retrospective Cohort Study to Examine Disease Progression in Retinitis pigmentosa Patients Seen at the University of Ottawa Eye InstituteKandakji, Lynn 15 January 2024 (has links)
Retinitis pigmentosa (RP) is the most common form of inherited retinal degeneration, heterogenous in its clinical presentation and genetic cause. Understanding the short-term disease mechanisms is pivotal for the development of new therapies. Upcoming clinical trials will take genotype-agnostic approaches; therefore, a comprehensive analysis of progression that encompasses many genetic factors will be needed. In this 10-year retrospective cohort study, rates of progression were measured, structurally and functionally, in 85 RP patients seen at the Ottawa Eye Institute. Parameters examined were the ellipsoid zone (EZ) length on an optical coherence tomography (OCT) image, Humphrey and Goldmann visual fields (VF), and full-field and multifocal electroretinograms (ERGs). RP is revealed to have a 1st order exponential decay pattern of loss, with mean rates of decline of 7.65 %/year for ellipsoid zone (EZ) length, 6.35%/year, 4.39%/year, and 1.57%/year for the Humphrey VF 30-2, 24-2, and 10-2 mean deviation (MD) respectively, and 5.22%/year, 7.77%/year, 6.77%/year, 6.80%/year, and 12.45%/year for Goldmann V4e, III4e, I4e, I3e, and I2e isopter lengths, respectively. In cases where different diagnostic tests were conducted within 3 months of each other, the data was analysed to determine if there was a positive correlation between the diagnostic tests. Ellipsoid zone length and Humphrey 24-2 mean deviation exhibited the strongest association with a coefficient of 0.99. The study reveals structural and functional changes in advanced retinitis pigmentosa and presents a protocol for assessing short-term progression.
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Optical Coherence Tomography for the Screening of Donor Corneas and Examination of the Retinal Nerve Fiber Directional ReflectanceLin, Roger Chin 11 April 2006 (has links)
No description available.
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ULTRA HIGH RESOLUTION AND CONTRAST SENSITIVE OPTICAL COHERENCE TOMOGRAPHYWang, Hui 03 April 2008 (has links)
No description available.
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Imaging the Embryonic Heart with Optical Coherence TomographyJenkins, Michael W. 04 April 2008 (has links)
No description available.
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3-D Volumetric Optical Coherence Tomography Imaging and Image Analysis of Barrett's EsophagusKang, Wei 14 April 2011 (has links)
No description available.
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Foveal Phase Retardation Correlation with Henle Fiber Layer ThicknessCiamacca, Marisa Lynn 07 September 2017 (has links)
No description available.
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Deep neural networks for A-line based plaque classification in intravascular optical coherence tomography imagesKolluru, Chaitanya, Kolluru January 2018 (has links)
No description available.
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Characterization and Hydration with the SL-OCTMorin, Craig E. 12 September 2008 (has links)
No description available.
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Validation of Optical Coherence Tomography-Based Crystalline Lens Thickness Measurements in ChildrenLehman, Bret M. 14 July 2009 (has links)
No description available.
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