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Weak optical signals have to be measured in different fields of sciences including chemistry and biology. For example, very low levels of fluorescence emission should be detected from the spots on a DNA microarray that correspond to weakly expressed genes. High sensitivity charge-coupled devices (CCDs) are used in these applications. CCDs require special fabrication and are difficult to integrate with other circuits. CMOS is the technology used for fabrication of CPUs and other widely used digital components. CMOS is not optimized for light detection. CMOS circuits are however cheap, low power and can integrate several components. Active pixel sensor (APS) is the most common pixel structure for CMOS photodetector arrays. In this work we provide an accurate analysis of the APS signal using new models for the capacitance of the photodiode. We also provide a complete noise analysis of the pixel to calculate the SNR of the pixel and provide optimum operation points. We propose a new mode of operation for APS that can achieve at least l 0 dB higher SNR, than conventional APS, at light levels of less than 1 μW/cm^2. We fabricated several APS pixels in CMOS 0.18 μm technology and measured them to confirm the proposed analyzes. There are applications like fluorescence lifetime imaging that require both sensitivity and fast response. Photomultiplier tubes (PMTs) are commonly used in these applications to detect single photons in pico- to nano-seconds regime. PMTs are bulky and require high voltage levels. Avalanche photodiodes (APDs) are the semiconductor equivalent of PMTs. We have fabricated different APDs along with different peripheral circuitries in CMOS 0.18 μm technology. Our APDs have a 5.5 percent peak probability of detection of a photon at an excess bias of 2 V, and a 30 ns dead time, which is less than the previously reported results. The low price of CMOS makes modem diagnosis devices more available. The low power of CMOS leads to battery-driven hand-held imaging solutions, and its high integration leads to miniaturized imaging and diagnosis systems. A low-light-level CMOS imager paves the way for the future generation of biomedical diagnosis solutions. / Thesis / Doctor of Philosophy (PhD)

Orientadores: Edson Moschim, Luiz Henrique Bonani do Nascimento / Tese (doutorado) - Universidade Estadual de Campinas, Faculdade de Engenharia Eletrica e de Computação / Made available in DSpace on 2018-08-21T20:14:55Z (GMT). No. of bitstreams: 1 Galdino_Lidia_D.pdf: 15165913 bytes, checksum: b0a79c7ac69b13cce3baf82b480c99fc (MD5) Previous issue date: 2012 / Resumo: A exigência crescente de se atingir maiores taxas de bits para satisfazer a demanda por largura de banda na internet tem motivado a investigação de dispositivos totalmente ópticos que viabilizem o desenvolvimento de redes ópticas transparentes (TON). O intuito dessas redes é manter o fluxo de dados sempre no domínio óptico, eliminando o gargalo no processamento das conversões óptico-elétricas e eletro-ópticas existentes nos atuais sistemas de comunicações ópticas. Neste trabalho foram investigadas, por meio de experimentos e simulações computacionais, técnicas de processamento óptico de sinais. Estas técnicas utilizam o fenômeno da mistura de quatro ondas (FWM) para multiplexar as informações de dois sinais em um único sinal. Em especial, foram investigadas duas novas técnicas para codificação e regeneração totalmente óptica do sinal não coerente de multiplexação por divisão de códigos ópticos no acesso (OCDMA). Estas técnicas convertem e regeneram no domínio totalmente óptico o sinal modulado em intensidade on-off keying (OOK) e o sinal modulado pelo chaveamento por desvio de fase diferencial (DPSK) no sinal OCDMA. Os resultados obtidos comprovaram que ambas as técnicas propostas funcionam corretamente. O sinal de saída OCDMA apresentou ganho na potência de regeneração de 1,69 dB em relação ao sinal de entrada OOK ou DPSK. A aplicação das técnicas de conversão e regeneração totalmente ópticas propostas, deu origem ao estudo da tecnologia híbrida de multiplexação por divisão de comprimentos de onda com a multiplexação por divisão de códigos ópticos (WDM/OCDM) na camada de transporte de uma rede TON. Heurísticas para atribuição de códigos ópticos e comprimentos de onda, bem como arquiteturas de conversão de códigos ópticos e comprimentos de onda foram propostas. Dos resultados, comprovou-se que a heurística Random-Random apresenta um melhor desempenho quando analisada a probabilidade de bloqueio. Ainda, a arquitetura de conversão esparsa parcial de códigos ópticos e comprimentos de onda (SPOCC/SPWC) melhora a utilização de recursos de rede, diminuindo o custo de implementação da rede / Abstract: The growing demand to achieve higher bit rates to satisfy the bandwidth in the internet has motivated the investigation of all optical devices that enable the development of transparent optical networks (TON). The idea is that the data stream always remains in the optical domain, eliminating the bottleneck in the processing of electro-optical conversion that existing in current optical communication systems. In this work new all-optical signal processing techniques are investigated through computer simulations and experiments. These techniques utilize the four wave mixing effect to multiplex information of two input signals into a single one. In particular, two new all-optical techniques for coding and regeneration incoherently optical code division multiple access (OCDMA) signals were investigated. These all optical techniques convert and regenerate the optical signal modulated in intensity, on-off keying (OOK) and / or the optical signal modulated in differential phase shift (DPSK) on OCDMA signal. The results showed that both techniques worked properly. The output OCDMA signal presented an improved in the optical power regeneration of 1,69 dB. The application of all optical conversion technique with simultaneous signals regeneration led to the study of hybrid wavelength division multiplexing with optical code division multiplexing (WDM/OCDM) technology at the transport layer in a TON network. Heuristics for assigning optical codes and wavelengths as well as optical codes and wavelengths conversion architectures were proposed. From the results, it was shown that Random-Random heuristic has a better performance when analyzing the blocking probability. Still, the sparse partial optical code and wavelength conversion (SPOCC/SPWC) architecture improves the utilization of network resources, reducing the deployment cost of network / Doutorado / Telecomunicações e Telemática / Doutor em Engenharia Elétrica

Les taches blanches sont liées à l'hypominéralisation sous la surface de l'émail et sont la 1ère étape du développement de la carie dentaire. La détection précoce des caries dentaires naissantes avant qu'elles n'atteignent le stade de la cavitation offre une opportunité pour des soins dentaires efficaces. Pour réaliser les objectifs de cette étude qui sont de renforcer l'idiome des soins minimalement invasifs, nous avons identifié un modèle de cycle de pH modifié qui permet d’imiter les conditions intra-buccales qui conduisent à la formation de lésions de type tache blanche, dans un court laps de temps. Des techniques optiques non invasives, comme la microscopie Raman confocale et la microscopie multiphotonique, ont été utilisées dans cette étude pour détecter de petits changements dans la composition chimique de l'émail in vitro.De plus, la technique de nano-indentation a été appliquée pour étudier les changements dans les propriétés mécaniques de l'émail et les relier à ceux affectant sa composition chimique après l'induction des caries, afin d‘ajouter de la spécificité chimique-mécanique aux informations sur les lésions sous-surface de l'émail. Les résultats obtenus démontrent un grand potentiel pour les techniques examinées, fournissant une base pour des applications intéressantes dans le diagnostic clinique de différentes pathologies dentaires. Pour résoudre le problème du traitement des lésions primitives sans intervention chirurgicale, l'efficacité de la crème GC Tooth Mousse et du dentifrice contenant de la nano-hydroxyapatite «KAREX» dans l'amélioration de la reminéralisation de l'émail déminéralisé par la localisation du phosphate de calcium amorphe à la surface de la dent a été inspectée. L'étude a indiqué le manque de preuves fiables soutenant l'efficacité des agents reminéralisants dans le traitement des taches blanches. Ce travail doit être poursuivi par d'autres études in-vitro et par des études cliniques. / White spot lesion is the subsurface hypomineralization of enamel indicating the 1st stage of dental caries development. Early detection of incipient dental caries before it reaches the stage of cavitation offers an opportunity for effective dental care. The objectives of this study were to strengthen the idiom of minimally invasive treatment. In order to achieve the specified goals; we have identified a modified pH cycling model that can mimic the intraoral conditions leading to white spot lesions formation in a short time. In addition, non-invasive optical techniques, such as confocal Raman microscopy and multiphoton microscopy were used in this study to detect small changes in the enamel chemical composition in vitro.Furthermore, nano-indentation technique was used to detect the changes in the mechanical properties of enamel and relate them to those affecting its chemical composition after caries induction in order to add chemico-mechanical specificity in providing important information about subsurface lesions in enamel. The obtained results demonstrate a great potential for the examined techniques, providing a basis for interesting applications in the clinical diagnosis of various pathological conditions in dentistry. To treatment the incipient carious lesions non-invasively, the effectiveness of GC Tooth Mousse cream and nHA containing-dentifrice "KAREX" in the remineralization of demineralized enamel through localizing amorphous calcium phosphate at tooth surface has been inspected. The study indicated a lack of reliable evidence supporting the efficacy of remineralizing agents in the treatment of white spot lesions. Within the limitations of this study, further laboratory studies together with clinical research are therefore required to increase the available knowledge on this prevalent subject.