- About
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The Global ETD Search service is a free service for researchers
to find electronic theses and dissertations. This service is
provided by the
Networked Digital Library of Theses and Dissertations.
Our metadata is collected from universities around the world. If you manage a university/consortium/country archive and want to be added, details can be found on the NDLTD website.
Search results
Showing 41 to 50 of 982 (0.055 seconds)Spelling suggestions: "subject:"osteoarthritis."" "subject:"dsteoarthritis.""
| 41 |
The importance of kinins in inflammatory joint diseasesBond, Alison P. January 1994 (has links)
No description available.
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| 42 |
Mechanical disruption of articular cartilage cells and matrixClements, Kristen Mary January 2000 (has links)
No description available.
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| 43 |
1,25-dihydroxyvitamin Dâ†3 in macrophages from the arthritic joint : regulation of synthesis by NSAIDs and effects on cytophagocytosisMolloy, Jill January 2001 (has links)
No description available.
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| 44 |
Development of personal computer based clinical motion analysis system and gait study of trunk and pelvis movements in hip patients with functional leg length discrepancyHattori, Tomokazu January 1997 (has links)
No description available.
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| 45 |
Knee joint failureMcAlindon, Timothy Edward January 1992 (has links)
No description available.
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| 46 |
An enzymatic study of cartilage degradationGadher, S. J. January 1988 (has links)
No description available.
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| 47 |
Differential gene expression in normal and diseased human articular cartilageMcKenna, Louise Agnes January 1999 (has links)
No description available.
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| 48 |
Changes in glycosaminoglycan epitopes on cartilage proteoglycans in joint diseasesHazell, Paula Kaye January 1995 (has links)
No description available.
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| 49 |
Impulsive loading in gonarthrosisChen, Wen-Ling January 1998 (has links)
No description available.
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| 50 |
The response of articular cartilage to impact loadingJeffrey, Janet Elizabeth January 2009 (has links)
In this study an <i>in vitro</i> model was used to simulate joint trauma by subjecting explants of articular cartilage to a single impact load using a specially designed drop-tower loading machine for which two different loading attachments were developed. The aim was to compare the biophysical effects of impact loading on bovine and human cartilage. The proteolytic lysomal enzyme, cathepsin B and the proinflammatory mediators, prostaglandin E<sub>2</sub> (PGE<sub>2</sub>) and nitric oxide (NO) have been implicated in the degradation of cartilage following trauma. This study aimed to investigate the role of these degradatory mediators. Human cartilage was found to be less damaged than bovine after impact and the type of loading attachment affected the nature of the damage observed. Following an impact load on human cartilage explants, the levels of glycosaminoglycans (GAGs), a measure of cartilage breakdown, in the culture medium and the percentage of apoptotic chondrocytes were significantly increased. The levels of pro-cathepsin B were significantly increased in the culture medium compared to unloaded controls. Addition of human cystatin C and the synthetic cathepsin B inhibitor, CA-074Me, reduced this release. However these inhibitors had no effect on the release of GAGs or the levels of apoptosis following impact. A marked increase in PGE<sub>2</sub> and NO was measured in the medium following an impact load, which was reduced by the selective cyclooxygenase-2 (COX-2) inhibitor, celecoxib, and the non-selective inhibitor, indomethacin. These inhibitors reduced chondrocyte apoptosis but no change was observed in the release of GAGs from the explants. This <i>in vitro</i> study indicates that cell viability and matrix degeneration are separately regulated and that it is unlikely that cathepsin B or COX-2 inhibition alone would slow down or prevent the development of secondary osteoarthritis.
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