This observational study was conducted to evaluate the anatomic relationship between the proximocaudal femoral joint capsule insertion and the femoral caudolateral curvilinear osteophyte (CCO), across ancient and modern domestic and non-domestic canids. Museum specimens of proximal femora were screened for presence of remnant enthesophytes of the caudal joint capsule insertion (first inclusion criterion) and then for the CCO (second inclusion criterion). The initially screened population included 267 dry bone specimens: Six Canis species, hybrid coyote × domestic dog, and five vulpines (three Vulpes species, one Urocyon, and one Nyctereutes). Proximocaudal joint capsule insertion remnant enthesophytes were limiting at n = 19 specimens: Seven ancient domestic dogs, four modern coyotes, two ancient coyotes, two modern hybrid coyote × dog, two modern red foxes, and two modern raccoon dogs. The joint capsule enthesophytes are associated with inflammation, but are observed far less frequently than the CCO. The CCO is seen radiographically but is visible more frequently by direct inspection. The primary inclusion criterion necessarily was a visible caudal joint capsule insertion; spatial relationships of the CCO can be assigned with confidence only when a capsule insertion line can be recognized clearly. We demonstrate that the anatomic CCO associates with the joint capsule insertion being nonspecific and species-independent. A joint capsule insertion-CCO spatial relationship across species is an important new observation, strongly indicating that both are pathological features. Our data indicate need for new research to characterize the canid coxofemoral joint and its overt and incipient pathology in a phylogenetic context. Anat Rec, 302:2164–2170, 2019.

Arthritis is one of the most common manifestations of aging and is the single largest cause of disability in the UK, US, Australia, and Canada among people age 30 years and older. Osteoarthritis of appendicular joint surfaces exhibits alterations of bony tissue in and around the joint surface. The degree to which osteoarthritis of articular surfaces occurs as a function of age and sex can be resolved with cemetery populations of known individuals, such as the Terry (19-20th century) and Spitalfields (17-18th century) collections upon which I report (n = 322; 162 males and 160 females). Using the five point scoring system 0-4 of lipping from the Chicago Standards Guide I ask whether (1) age has an influence on the accumulation of OA; (2) sex differences are present in patterns of OA; and (3) population origin is responsible for explaining intensity of OA.

Orientador: Lúcia Helena Simões da Costa-Paiva / Tese (doutorado) - Universidade Estadual de Campinas, Faculdade de Ciências Médicas / Made available in DSpace on 2018-08-18T22:13:15Z (GMT). No. of bitstreams: 1 Ferreira_NevilledeOliveira_D.pdf: 2260205 bytes, checksum: 4735926d615eaa3b10d11ae68acd6940 (MD5) Previous issue date: 2011 / Resumo: Objetivo: Avaliar a prevalência de fratura vertebral, alterações radiológicas, dor nas costas, e associação com qualidade de vida em mulheres com osteoporose pós-menopausa e validar a versão na língua portuguesa do questionário de qualidade de vida QUALEFFO-41 em mulheres brasileiras com fratura vertebral. Métodos: Este estudo coletou dados de 126 mulheres com osteoporose e 43 mulheres sem osteoporose. O estudo de prevalência de fratura vertebral (FV), osteófitos e dor nas costas, foi um corte transversal com o total de 126 mulheres com osteoporose lombar pós-menopausa diagnosticada pela densitometria óssea selecionadas no Ambulatório de Menopausa do CAISM. As mulheres responderam entrevista sobre dados sociodemográficos e clínicos, e o questionário QUALEFFO-41. Todas realizaram radiografia de coluna para pesquisa de alterações radiológicas. Para a análise estatística utilizou-se os testes de Mann-Whitney ou T de Student, testes exato de Fisher ou qui-quadrado e regressão múltipla. O estudo de validação do QUALEFFO-41 foi realizado apenas com 43 com FV por osteoporose (grupo fratura) e 43 sem osteoporose (grupo controle), pareadas por idade (±3 anos). Foram aplicados o QUALEFFO-41 e o SF-36 (comparação teste-reteste). Calculou-se o coeficiente ? de Cronbach, coeficiente de Correlação Intraclasse, coeficiente Kappa (k), Odds ratio e curva ROC. Resultados: Os resultados foram apresentados em três artigos. No primeiro artigo, a prevalência de FV nas 126 mulheres foi de 34,1% e o tipo de FV mais prevalente foi a triangular anterior (45,9%). Não houve diferença na qualidade de vida (QV) entre as mulheres com osteoporose com e sem FV, porém o maior número de fraturas associou-se a pior QV. Os fatores associados à pior QV foram cor da pele não branca, obesidade, ausência de trabalho remunerado, sedentarismo, baixa escolaridade e não uso de medicação para osteoporose. No segundo artigo sobre prevalência de alterações radiológicas e dor nas costas, a prevalência de FV foi de 34,1 % e de osteófitos de 92,1%. A prevalência de dor nas costas foi de 66,7% e observou-se associação entre a dor nas costas com a presença de osteófitos (p=0,0157) e pior QV. No terceiro artigo de validação do QUALEFFO-41, o coeficiente ? de Cronbach dos domínios variou entre 0,74 e 0,84; o ICC dos domínios variou entre 0,67 e 0,90; a maioria das questões apresentou um coeficiente k maior do que 0,50 e demonstrou boa validade convergente e discriminante. As mulheres do grupo FV apresentaram comprometimento na QV em ambos os questionários (p<0,05) e houve boa correlação entre os domínios do QUALEFFO-41 e os seus correspondentes do SF-36, exceto para Função Social. A avaliação pela curva ROC e regressão logística demonstrou que todos os domínios do QUALEFFO-41 foram significativamente preditivos de FV. Conclusão: A prevalência de FV por osteoporose foi alta, com comprometimento na QV independente da FV. Também houve uma alta prevalência de dor nas costas associada à presença de osteófitos e pior QV. O QUALEFFO-41 na língua portuguesa pode ser utilizado em mulheres brasileiras com FV por osteoporose, pois mostrou ter boas características psicométricas, demonstrando comprometimento na QV e boa capacidade de discriminar a QV em mulheres com FV / Abstract: Objective: To evaluate the prevalence of vertebral fractures, radiographic abnormalities, back pain, and association with quality of life in women with postmenopausal osteoporosis, and to validate the Portuguese version of the quality of life QUALEFFO-41 questionnaire in Brazilian women with osteoporosis vertebral fractures. Methods: This study was conducted with a total of 126 women with osteoporosis and 43 women without osteoporosis. The study of the prevalence of vertebral fractures (VF), osteophytes and back pain, was a cross sectional study with a total of 126 postmenopausal women, with lumbar osteoporosis diagnosed by bone densitometry, selected from the Menopause Outpatient Clinic of the Women's Integrated Healthcare Center (CAISM). The women were interviewed about sociodemographic/clinical data and the QUALEFFO-41 questionnaire. Lumbar spine radiograph was performed in all participants to study radiographic abnormalities. The statistical analysis was performed by the Mann-Whitney or Student's T-test, Fisher's Exact or Chi-square, and multiple regression. The QUALEFFO-41 validation study was conducted with only 43 women with osteoporosis VF (fracture group) and 43 women without osteoporosis (control group), age-matched (±3 years). The QUALEFFO-41 questionnaire was administered twice in four weeks and compared to SF-36 (testretest). For analysis were calculated the Cronbach's ? Coefficient, the Intraclass Correlation Coefficient, the Kappa's Coefficient, Odds ratio and ROC curve. Results: The results were presented in three articles. In the first, the prevalence of VF in the 126 women was 34,1% and the most prevalent type of VF was anterior wedge (45.9%). No difference was observed in the quality of life (QOL) between women with osteoporosis with and without VF, although there was direct correlation between number of VF and worse QOL. Factors associated with worse QOL were non-white skin color, obesity, no paid job, sedentary lifestyle, low level of school education and non-use of osteoporosis drugs. In the second article about prevalence of radiographic abnormalities and back pain, the prevalence of VF was 34,1 % and of 92,1% to osteophytes. Back pain in the last four weeks was prevalent in 66.7% of women and it was observed a association between back pain with osteophytes presence (p=0,0157) and worse QOL. In the third article of validation of QUALEFFO-41, the Cronbach's ? coefficient of the domains ranged between 0,74 and 0,84; the ICC of the domains ranged between 0,67 and 0,90; the majority of questions showed a k coefficient higher than 0,50 and demonstrated good convergent validity and discriminant validity. The group of women with VF showed impairment in the QOL in both questionnaires (p<0,05) and there was a good correlation among the QUALEFFO-41 domains and their corresponding SF- 36 domains, except for Social Function. All QUALEFFO-41 domains were significantly predictive of VF on assessment of the ROC curve. Conclusion: The prevalence of osteoporosis VF was high, with impairment of the QOL independent of VF. There is also a high prevalence of back pain associated with osteophytes and worse QOL. The Portuguese version of the QUALEFFO-41 may be used in Brazilian women with osteoporosis VF because it shows good psychometric characteristics, the impairment of the QOL and good ability to discriminate QOL in women with osteoporosis VF / Doutorado / Fisiopatologia Ginecológica / Doutor em Ciências da Saúde