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  • About
  • The Global ETD Search service is a free service for researchers to find electronic theses and dissertations. This service is provided by the Networked Digital Library of Theses and Dissertations.
    Our metadata is collected from universities around the world. If you manage a university/consortium/country archive and want to be added, details can be found on the NDLTD website.
111

Inhibierung Superantigen-induzierter T-Zellproliferation durch neue synthetische Peptide

Wessels, Johannes Theodor. January 2002 (has links)
Tübingen, Univ., Diss., 2002.
112

Generierung von löslichen rekombinanten Multimeren zur Hemmung des HIV-1-Entry

Kreutz, Alexandra. Unknown Date (has links) (PDF)
Frankfurt (Main), Universiẗat, Diss., 2008.
113

Synthese von Modellpeptiden zur Konformationsuntersuchung

El Rahman, Somaya Abd, January 1981 (has links)
Thesis (doctoral)--Tübingen, 1981.
114

Untersuchungen zu Sequenzierungen von Peptiden A. Isotopenmarkierte Phenylthiohydantoinaminosäuren. B. Enzymatische Hydrolyse und HPLC-MS-Identifizierung der Spaltprodukte /

Hartmann, Marina, January 1979 (has links)
Thesis (doctoral)--München, 1979.
115

Synthese von suraminanalogen Verbindungen mit Chinolin-Teilstruktur : potentielle Virustatika und Zytostatika /

Schulz, Joachim. Unknown Date (has links)
Universiẗat, Diss., 1995--Bonn.
116

Charakterisierung und Identifizierung von Membranproteinen auf der Ebene von Peptiden

Meyer, Björn. Unknown Date (has links)
Univ., Diss., 2008--Frankfurt (Main).
117

Peptidcluster in der Gasphase

Abd Elrahman, Osama. Unknown Date (has links) (PDF)
Universiẗat, Diss., 2003--Kiel.
118

Bindung von MARCKS an anionische Phospholipidvesikel, Aggregations- und Transportverhalten von synthetischen Gentransfer-Komplexen eine Untersuchung mit Fluoreszenz-Korrelationsspektroskopie /

Rusu, Laura. Unknown Date (has links) (PDF)
Universiẗat, Diss., 2004--München.
119

Atrial natriuretic factor integrated effects on blood pressure, natriuresis, and renal medullary blood flow in man /

Janssen, Wilbert Martien Theodoor. January 1994 (has links)
Proefschrift Groningen. / Met lit. opg. en een samenvatting in het Nederlands.
120

Bio-engineering of antibiotic enduracidin biosynthetic pathways and PreQ1 riboswitch

Wu, Ming-Cheng January 2011 (has links)
Non-ribosomally synthesised natural products derived mainly from bacteria and fungi act as important therapeutic agents. Due to their complex structures it is difficult to chemically synthesise such compounds, therefore the engineering of biosynthetic and biocatalytic pathways that are vital for their production are the aims of this thesis. The first project involved the study of the biosynthesis of 3-O-methyl aspartic acid (OmAsp) in the antibiotic A54145. We demonstrated that LptL functions as an asparagine hydroxylase. We also predicted that LptJ and LptK are involved in the biosynthesis of OmAsp, although we did not find evidence of this non-standard amino acid in the antibiotic CDA when we over-expressed both proteins in Streptomyces coelicolor. The second project involved the study of the chlorination and mannosylation of hydroxyphenyl glycine (Hpg) residues in ramoplanin. We over-expressed the putative chlorinase and mannosyl transferase separately in the enduracidin-producer, in which the production of enduracidin has been characterised. We then found that trichlorinated and mannosylated enduracidin analogues were produced. The final project involved the re-engineering of a preQ1 riboswitch. We successfully created ten preQ1 riboswitch mutants fused to the reporter gene lacZ in Bacillus subtilis, all of which showed different levels of β-galactosidase activity. Subsequently, we found that the preQ1 C17U mutant riboswitch can respond specifically to the synthetic ligands 5-(aminomethyl)furo[2,3-d]pyrimidine-2,4-diamine (D6) and 2,4-diamino-7H-pyrrolo[2,3-d]pyrimidine-5-carbonitrile (D9) to control gene expression in a dose dependent manner. The results described here show the successful production of variant antibiotics by bio-engineering and the use of an engineered preQ1 riboswitch as a tool for regulating gene expression.

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