- About
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The Global ETD Search service is a free service for researchers
to find electronic theses and dissertations. This service is
provided by the
Networked Digital Library of Theses and Dissertations.
Our metadata is collected from universities around the world. If you manage a university/consortium/country archive and want to be added, details can be found on the NDLTD website.
Search results
Showing 291 to 300 of 2546 (0.018 seconds)| 291 |
An investigation of the structure of ions in the gas phase by tandem mass spectrometryGill, Andrew Christopher January 1998 (has links)
No description available.
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| 292 |
Autoimmune disease in rodents : control and specificityShipton, Deborah January 1999 (has links)
No description available.
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| 293 |
Changes in gastrointestinal secretion in relation to advancing age and Helicobacter pylori infectionNewton, Julia L. January 1998 (has links)
No description available.
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| 294 |
Discovery of tumour necrosis factor receptor-1 (p55) binding peptides using a phage display libraryPrendergast, D. January 2001 (has links)
No description available.
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| 295 |
Development of region-specific antisera to GLP-1 : physiological and pathological studiesSitu, Chen January 1997 (has links)
No description available.
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| 296 |
Characterisation of a novel protein export pathway in Escherichia coliStanley, Nicola Ruth January 2000 (has links)
No description available.
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| 297 |
Development of novel solid-phase chemistry and building blocks for the synthesis of antimicrobial peptidesMellor, Sarah Louise January 1998 (has links)
No description available.
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| 298 |
Mechanism based inhibitors of tyrosine kinasesPage, Timothy C. M. January 1994 (has links)
No description available.
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| 299 |
Vertebrate development and physiology in response to augmented pituitary adenylate cyclase-activating polypeptide (PACAP)Drncova, Petra Venc. 10 April 2008 (has links)
No description available.
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| 300 |
Dissecting the Structure-Activity Relationship of Hairpinin, a Plant Derived Antimicrobial PeptideSterby, Mia January 2014 (has links)
Antibiotic resistance is a growing health issue that necessitates development of alternative drugs with antimicrobial properties. Antimicrobial peptides are a promising group of compounds in this respect and are used by all varieties of living organisms to defend against invading or competing organisms. Hairpinin is an antimicrobial peptide isolated from Echinochloa crus-galli that has previously been found to have antifungal activity. In this study, truncated variants of hairpinin were synthesized and their antifungal activity tested against Candida albicans, Aspergillus fumigatus, and Saccharomyces cerevisiae to identify the minimum structural element of hairpinin required for maintained activity. Hairpinin was active against all three fungi with a minimum inhibitory concentration ranging between 0.6 μM - 5 μM depending on strain and growth media. Two truncated versions were synthesized in this study by solid-phase peptide synthesis, also resulting in a dimer of one of the derivatives, and their antifungal activity was assessed together with four other truncated peptides previously synthesized. The findings indicated that hairpinins C-terminal end together with an inflexible central part stabilized by at least one disulfide bond was vital for activity. The mechanism of action in which hairpinin inhibits fungi was examined by liposome leakage assay of Escherichia coli and Saccharomyces cerevisiae model membranes. It was concluded that the mechanism of action did not involve membrane disruption, a common mechanism among similar antimicrobial peptides. Although hairpinin displayed potent antifungal activity, it was found to be proteolytically unstable in serum. To improve hairpinins value in pharmaceutical context stability has to be improved while preserving the important structural elements.
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