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  • About
  • The Global ETD Search service is a free service for researchers to find electronic theses and dissertations. This service is provided by the Networked Digital Library of Theses and Dissertations.
    Our metadata is collected from universities around the world. If you manage a university/consortium/country archive and want to be added, details can be found on the NDLTD website.
11

The theatre of the self : poetic identity in the plays of Helene Cixous and Marina Tsvetaeva

Dobson, Julia January 1996 (has links)
This comparative study of the theatre of Helene Cixous and Marina Tsvetaeva proposes a reading of their plays as a coherent corpus engaged specifically with the representation of poetic identity. Tsvetaeva's and Cixous' plays present a diverse range of characters who can be identified as poet-selves and who struggle to assert their identity in hostile environments. An inherent link is established between the thematic and the generic. Cixous' and Tsvetaeva's adoption of the theatre as genre in which to develop their conceptualisations of poetic identity is shown to be important to the thematic contexts in which the poet-selves are constructed. This study defines four elements: language, exile, sexual difference and Greek mythology, which are shown to be common to the representation of poetic identity in Tsvetaeva's and Cixous' plays. Each element is addressed in turn in Chapters Two to Five and its role in both writers' constructions of poetic identity in their individual plays is explored and problematised. The conclusion evaluates the radical nature of Cixous' and Tsvetaeva's dramatisations of poetic identity in the context of the representation of the female poet and discusses the evolution of this theme in a chronological approach to their theatre.
12

Gap junction enhancer as an anti-cancer agent via GJIC-independent and -dependent pathways

Ding, Ying January 1900 (has links)
Doctor of Philosophy / Department of Biochemistry and Molecular Biophysics / Thu Annelise Nguyen / Gap junctions (GJ) are intercellular channels connecting adjacent cells, allowing small molecules to transport between cells, thereby maintaining all homeostasis. Loss of gap junctional intercellular communication (GJIC) and/or connexins, the gap junction proteins, is a hallmark of cancer. Restoration of GJIC and/or increase of connexin expression have been related to the reduction of tumorigenesis. Connexins have been reported as tumor suppressors due to both GJIC-independent and -dependent mechanisms. Therefore, development of effective agents or methods to enhance GJIC and restore connexin expression in cancer cells is a new strategy in cancer treatment. PQ1, 6-Methoxy-8-[(3-aminopropyl)amino]-4-methyl-5-(3-trifluoromethyl-phenyloxy)quinoline, has been demonstrated to increase GJIC, restore connexin expression, and exert anti-cancer effects on T47D breast cancer cells. Studies of apoptotic pathways showed that PQ1 activated both extrinsic and intrinsic apoptotic pathways, indicating that PQ1 exerts its anti-cancer effects via a GJIC-independent mechanism through the induction of apoptosis. Combinational treatment of PQ1 and cisplatin showed that PQ1 counteracted cisplatin-induced inhibition of GJIC and reduction of connexin expression, thereby increasing the efficacy of cisplatin in T47D cancer cells via a GJIC-dependent mechanism. Further studies of drug distribution and toxicity revealed that administration of PQ1 by oral gavage can be achieved with low toxicity to normal vital organs. All the results suggest that PQ1, a gap junction enhancer, can function as an anti-cancer agent and potentiate the efficacy of antineoplastic drugs via both GJIC-independent and -dependent pathways.

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