Class of 2016 Abstract / Objectives: To verify a set of translated medication labels in consultation with native speakers of non-English languages, specifically for this study: Amharic, Arabic, Chinese (Mandarin), Somali, Spanish, Tigrinya, and Vietnamese. Methods: Native speakers of target languages were recruited from academic and community organizations in the Tucson area. Participants were asked to review a set of translated directions and complete a survey regarding the validity and comprehensibility of the translations. In some cases, a short interview was used to clarify any comments or corrections made by the participants. Results: Surveys were completed by 23 participants, 12 men and 11 women, covering seven languages, with an uneven distribution between languages. Directions in Somali were the least problematic, with relatively strong agreement between respondents. Amharic directions were rated poorly and scored consistently worse than the overall average. Tigrinya had the most variation between respondents compared to other languages. Chinese, Spanish, and Vietnamese all received rather high scores, but analysis is complicated by a small sample size for each. Among responses to the open-ended questions, comments regarding word choice were the most common, for various reasons. Conclusions: We were able to validate some of the provided translations, but found that certain languages posed more problems than others, and these translations would need to undergo further review before they can be reliably used in clinical practice.

Class of 2016 Abstract / Objectives: To first educate undergraduates involved in social sororities about prescription stimulant medications and to evaluate the effectiveness of an educational intervention in influencing the attitudes and beliefs regarding prescription stimulant medication use of undergraduates involved in social sororities. Methods: The intervention, an educational session, was presented to undergraduates involved in social sororities. The questionnaire collected demographic data regarding gender, age, ethnicity, race, undergraduate year, grade point average, type of sorority member, history of an attention-deficit/hyperactivity disorder (ADHD) diagnosis, and previous or current non-medical use of prescription stimulants. The participants’ attitudes and beliefs on nine statements regarding prescription stimulants were queried pre- and post-intervention using a four-point Likert scale ranging from strongly disagree to strongly agree. To analyze changes in attitudes and beliefs, Mann-Whitney test was used. Results: One hundred sixty-three sorority members participated in the study. The average age of participants was 19 years with the majority of respondents identifying as an active sorority member (81%) and in their first year of undergraduate study (69%). There was a statistically significant change in beliefs regarding the safety (p < 0.01) and health risks (p = 0.02) associated with prescription stimulants. There was no significant difference in topics relating to addiction, legal issues of taking someone else’s prescription medications, emotional and academic outcomes from the use of prescription stimulants. Conclusions: The educational program presented by pharmacy students was effective in changing the beliefs and attitudes regarding safety and health risks of prescription stimulants among undergraduate students involved in social sororities.

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Introduction : Les guides de pratique recommandent que les patients avec une maladie artérielle périphérique (MAP) soient traités médicalement afin de réduire la survenue d’évènements cardiovasculaires majeurs. Objectif : Identifier les facteurs associés à la prescription des thérapies préventives recommandées. Méthode : Les patients avec une MAP (n=362) traités consécutivement par angiodilatation fémoropoplitée entre 2008 et 2010 dans un centre tertiaire (CHU de Québec, Canada) ont été inclus dans l’étude. L’issue clinique primaire était la prescription de trois thérapies combinées. Résultats : Au total, 52% des patients recevaient la thérapie combinée. La présence d’au moins trois facteurs de risque cardiovasculaire (Rapport de cotes (RC)=4,51; IC 95% : 2,76-7,37) était le facteur le plus fortement associé à la prise des thérapies combinées. Conclusion : La prise en charge du risque cardiovasculaire des patients avec une MAP est encore sous-optimale. Une meilleure compréhension des barrières et des facilitateurs à l’application des recommandations est toujours nécessaire. / Introduction: Guidelines recommend that patients with peripheral arterial disease (PAD) should be medically treated to reduce the occurrence of serious cardiovascular events. Objective: To identified factors associated with the prescription of preventive therapies in patients with PAD. Methods: Consecutive patients with PAD (n=362) who underwent peripheral percutaneous transluminal angioplasty between 2008 and 2010 in one tertiary care center (CHU de Quebec, Canada) were considered for the study. Data were collected from the medical charts. The main outcome was the combined prescription of three therapies. Results: A total of 52% of the patients received the three combined therapies. Having at least three cardiovascular risk factors (Odds Ratio (OR)=4.51; 95% CI: 2.76-7.37) was the factor most strongly associated with the prescription of the combined therapies. Conclusion: Canadian patients with PAD are still not optimally managed. We still need to better understand the barriers and facilitators to the application of the guidelines in PAD patients.

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Research suggests that non-medical prescription drug (NMPD) use is becoming increasingly prevalent, particularly among adolescents. A critical step towards developing effective intervention efforts requires identifying adolescents who are at risk for NMPD use. An extensive literature suggests that both adolescents and adults with elevated anxiety sensitivity (AS) are at greater risk for problematic substance use, and a small body of work has identified similar links with NMPD use specifically among adults. However, most of this literature combines all prescription drugs into a single category, and no work has evaluated the relation between AS and NMPD use among adolescents. The current study endeavors to further this area of research by examining the relation between AS (overall and subscales) and NMPD use among adolescents. The project evaluated 276 adolescents (age 9-19 years) enrolled in a residential treatment program on level of AS, including sub-dimensions (i.e., cognitive, physical, and social), and NMPD use across three categories of drugs: analgesic (e.g., Vicodin®), anxiolytic (e.g., Xanax®), and stimulant (e.g., Adderall®). A series of logistic regression models indicated that overall AS predicted nonmedical analgesic use, but not anxiolytic/sedative or stimulant use. A closer investigation of the AS subscales demonstrated that only the AS social subscale significantly predicted nonmedical analgesic and anxiolytic/sedative use. These results suggest that AS is related to NMPD use among adolescents, highlighting the need for future work to disaggregate the assessment of NMPD use into specific drug classes and explore the subscale dimensions of AS.

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BACKGROUND: The nonmedical use of prescription medications among young people has escalated substantially in recent years. Certain subgroups of adolescents are at greater risk than others, including rural youth, however this has yet to be adequately quantified in Canada, and risk and protective factors in rural communities remain understudied. OBJECTIVES: The first objective of this thesis was to characterize the nonmedical use of prescription drugs in Canadian youth by age, gender, socioeconomic, immigrant and geographic statuses. The second objective was to examine time-use patterns among rural young people as they may relate to their risk of using prescription drugs recreationally. METHODS: Data were obtained from 10,429 youth in grades 9 and 10 across Canada who participated in the 2009/2010 Cycle of the Health Behaviour in School-aged Children survey. Participants documented information about their nonmedical use of opioid pain relievers, stimulants and sedative or tranquilizer medications in the past year. Cross-tabulations and multi-level regression analyses were used to determine proportions and estimate risk by demographic subgroups, and among 2393 rural youth, to examine associations with time-use patterns RESULTS: Females were 1.25 times more likely to report recreational use of pain relievers (95% CI: 1.04-1.51). Lower SES students were 2.41 times more likely to report recreational use of any type of medication (95% CI: 1.94-2.99). Pain reliever use was highest among rural youth living in close proximity to urban centres. Frequent peer time after school and in the evenings was associated with a 1.73 (95% CI: 1.10-2.73) and 2.16 times (95% CI: 1.30-3.60) increased risk of using prescription drugs recreationally, however associations were attenuated when adjusted for other risk factors. Non-participation in extracurricular activities was associated with a 50% increase in risk for nonmedical use of prescription drugs, even when adjusted for other risk factors. CONCLUSIONS: Females, those of low SES and some rural youth, especially those who do not participate in extracurricular activities, are at increased risk for using prescription drugs recreationally. Results from this thesis point to priority areas for public health and education in reducing harms associated with nonmedical use of prescription drugs. / Thesis (Master, Community Health & Epidemiology) -- Queen's University, 2013-10-01 22:39:42.815