No description available.

No description available.

The development of methods for site-selective derivatization of natural products to enable simultaneous arming and structure activity relationship (SAR) studies has shown great potential for the synthesis of pharmaceutical drug leads and cellular probes for mechanism of action studies. Herein, we describe a strategy to functionalize carboxylic acid and phenol containing natural products. This methodology relies on the in situ generation of diazoalkanes to form the corresponding carbonyl esters and phenolic ethers derived from natural products. We applied this process to several natural products, to begin demonstrating the utility of this methodology for the simultaneous arming and SAR studies of natural products. To expand our group’s nucleophile catalyzed aldol lactonization (NCAL) reaction for synthesizing highly substituted cyclopentane fused beta-lactones, we developed a nucleophile catalyzed, tandem Michael aldol lactonization (NCMAL) reaction. Herein, we show the synthetic utility of this reaction in varying the Michael donors and acceptors, developing a catalytic, enantioselective NCMAL, and synthesizing tricyclic-!-lactones. Furthermore, we initiated studies toward applying this new methodology to the synthesis of a lipase inhibitor, vibralactone.

As an understanding of users' tacit knowledge and latent needs embedded in user experience has played a critical role in product development, users’ direct involvement in design has become a necessary part of the design process. Various ways of accessing users' tacit knowledge and latent needs have been explored in the field of user-centred design, participatory design, and design for experiencing. User-designer collaboration has been used unconsciously by traditional designers to facilitate the transfer of users' tacit knowledge and to elicit new knowledge. However, what makes user-designer collaboration an effective strategy has rarely been reported on or explored. Therefore, interaction patterns between the users and the designers in three industry-supported user involvement cases were studied. In order to develop a coding system, collaboration was defined as a set of coordinated and joint problem solving activities, measured by the elicitation of new knowledge from collaboration. The analysis of interaction patterns in the user involvement cases revealed that allowing users to challenge or modify their contextual experiences facilitates the transfer of knowledge and new knowledge generation. It was concluded that users can be more effectively integrated into the product development process by employing collaboration strategies to intensify the depth of user involvement.

This research project explores opportunities for sustainable design in New Zealand. Recently a new framework for sustainable design was proposed by environmental chemist Michael Braungart and architect William McDonough who suggest that the current paradigm of cradle to grave product development is unable to provide a solution to the world’s current ecological crisis, and a “cradle to cradle” framework is more appropriate. They suggest that their approach, based on examples from nature, ensures that all human activities have a positive ecological footprint, capable of replenishing and regenerating natural systems, as well as guaranteeing that we are able to develop a world that is culturally and ecologically diverse. A group of New Zealand scientists was asked to evaluate the Cradle to Cradle design framework in an attempt to determine the potential of this, or other sustainable approaches, to design New Zealand products. The key findings from these interviews are described and were utilised to propose a new sustainable design framework – “design for ecosystem function”. In design for ecosystem function, biodiversity is placed central to the design decision-making process, alongside human user needs. This framework was then used to help explore the relationship between science and design, while developing three new, innovative and ecologically beneficial products. The three products, or ecological interventions, represent a design response to a range of ecological problems. They include a toy to help children reconnect with nature in urban ecosystems, a trap to assist lizard monitoring and conservation, and a shelter designed to enhance tree survival, and the colonisation of biodiversity in native forest restoration plantings.

Product development for any manufacturer today is both interesting and challenging. Marketing concepts need to be translated into a rational research and development process, which is scientifically supportable and deals with the logistic and administrative requirements of a modern, quality accredited manufacturing business. / Researchers suggest that the key for success in research and development is to involve all areas of a company, from marketing, purchasing and manufacturing to distribution and sales. For this reason it would be wise for companies to establish and maintain procedures that facilitate interaction between the different areas involved, so that innovative ideas are encouraged and integrated with the whole business in an effective and efficient way. The aim of this project was to establish a 'Research and Development Model' designed specifically for a small to medium sized Australian manufacturing business and to apply it to the development of a new range of nutraceutical beverages. / The research and development process involved all scientific and commercial aspects. Relevant data included market information, formulation and supplier details, chemical analyses and specifications for ingredients, results of microbiological analyses, sensorial panels and shelf stability trials. The Research and Development Model facilitated the product development process and it may be useful to other companies wishing to implement a new product range. / Thesis ([MApSc(BiomedicalScience)])--University of South Australia, 2006.

Product placement is now a US$7.76 billion industry, flourishing as advertisers attempt to combat audience sophistication, zipping, zapping, muting of commercials, TiVo, media multi-tasking, the Internet and digital television, all of which may signal the death knell of the interruptive commercial model. Yet whilst research on product placement is growing, it has not kept pace with the practice, and many findings do not converge across studies. This is likely the case because parameters remain undefined and there is no operational framework to describe how product placements are processed, and no agreement as to what effects are possible or how they should be examined. Most effects-based research has focussed on executional factors and what the product placement does to the audience member. This assumes that the recipient is a passive participant. However this thesis argues that the audience member is actually an active processor who should be the focus of research. This research distinguishes product placement from related activities and develops a new conceptual model of product placement processing. It puts a strong focus on the role of the audience member, stating that their level of familiarity of the placed brands, and their level of engrossment with the entertainment story will impact their recognition of product placements in that story. Applying Rasch Measurement Theory, an Audience Engrossment scale is developed and refined over four stages of data collection, with 1360 respondents across seven films, to capture the quality of people??s interaction with a film. The result is a scale comprising 19 feeling items, 10 arousal items, 6 appraisal items and 7 cognitive effort items. The scale was then tested as part of the conceptual model, with 191 participants watching The Island and completing questionnaires after the film relating to their recognition of brands within the film and their level of engrossment. Brand familiarity information was collected four weeks earlier. Onset prominence, high plot connection, dual modality and use by star were found to have the strongest direct effects on recognition, with brand familiarity and the four audience engrossment dimensions generally found to interact with the product placement characteristics as hypothesised.

This research project explores opportunities for sustainable design in New Zealand. Recently a new framework for sustainable design was proposed by environmental chemist Michael Braungart and architect William McDonough who suggest that the current paradigm of cradle to grave product development is unable to provide a solution to the world’s current ecological crisis, and a “cradle to cradle” framework is more appropriate. They suggest that their approach, based on examples from nature, ensures that all human activities have a positive ecological footprint, capable of replenishing and regenerating natural systems, as well as guaranteeing that we are able to develop a world that is culturally and ecologically diverse. A group of New Zealand scientists was asked to evaluate the Cradle to Cradle design framework in an attempt to determine the potential of this, or other sustainable approaches, to design New Zealand products. The key findings from these interviews are described and were utilised to propose a new sustainable design framework – “design for ecosystem function”. In design for ecosystem function, biodiversity is placed central to the design decision-making process, alongside human user needs. This framework was then used to help explore the relationship between science and design, while developing three new, innovative and ecologically beneficial products. The three products, or ecological interventions, represent a design response to a range of ecological problems. They include a toy to help children reconnect with nature in urban ecosystems, a trap to assist lizard monitoring and conservation, and a shelter designed to enhance tree survival, and the colonisation of biodiversity in native forest restoration plantings.

Teilw. zugl.: Mittweida, Hochsch., Diplomarbeit, 2005

Diss. Jönköping : Internationella handelshögskolan, 2006.