Wireless sensor networks (WSN) are event based systems that rely on the collective effort of densely deployed sensor nodes continuously observing a physical phenomenon. The spatio-temporal correlation between the sensor observations and the cross-layer design advantages are significant and unique to the design of WSN. Due to the high density in the network topology, sensor observations are highly correlated in the space domain. Furthermore, the nature of the energy-radiating physical phenomenon constitutes the temporal correlation between each consecutive observation of a sensor node. This unique characteristic of WSN can be exploited through a cross-layer design of communication functionalities to improve energy efficiency of the network. In this thesis, several key elements are investigated to capture and exploit the correlation in the WSN for the realization of advanced efficient communication protocols. A theoretical framework is developed to capture the spatial and temporal correlations in WSN and to enable the development of efficient communication protocols. Based on this framework, spatial Correlation-based Collaborative Medium Access Control (CC-MAC) protocol is described, which exploits the spatial correlation in the WSN in order to achieve efficient medium access. Furthermore, the cross-layer module (XLM), which melts common protocol layer functionalities into a cross-layer module for resource-constrained sensor nodes, is developed. The cross-layer analysis of error control in WSN is then presented to enable a comprehensive comparison of error control schemes for WSN. Finally, the cross-layer packet size optimization framework is described.