Thesis (M. Sc.)--Carleton University, 1993. / Includes bibliographical references. Also available in electronic format on the Internet.

Thesis (Ph. D.)--University of Wisconsin--Madison, 1983. / Typescript. Vita. eContent provider-neutral record in process. Description based on print version record. Includes bibliographical references (leaves 242-248).

Thesis (Ph. D.)--University of Rhode Island, 2006. / Includes bibliographical references (leaves 108-112).

Thesis (Ph. D.)--Ohio State University, 2007. / Title from first page of PDF file. Includes bibliographical references (p. 226-232).

Thesis (Ph. D.)--University of Texas at Austin, 1999. / Vita. Includes bibliographical references (leaves 135-153). Available also in a digital version from Dissertation Abstracts.

Thesis (Ph. D.)--University of Washington, 2000. / Vita. Includes bibliographical references (p. 142-147).

Master of Science / Department of Electrical and Computer Engineering / Caterina M. Scoglio / West Nile virus (WNV) ---a mosquito-borne arbovirus--- entered the USA through New York City in 1999 and spread to the contiguous USA within three years while transitioning from epidemic outbreaks to endemic transmission. The virus is transmitted by vector competent mosquitoes and maintained in the avian populations. WNV spatial distribution is mainly determined by the movement of residential and migratory avian populations. We developed an individual-level heterogeneous network framework across the USA with the goal of understanding the long-range spatial distribution of WNV. To this end, we proposed three distance dispersal kernels model: 1) exponential ---short-range dispersal, 2) power-law ---long-range dispersal in all directions, and 3) power-law biased by flyway direction ---long-range dispersal only along established migratory routes. To select the appropriate dispersal kernel we used the human case data and adopted a model selection framework based on approximate Bayesian computation with sequential Monte Carlo sampling (ABC-SMC). From estimated parameters, we find that the power-law biased by flyway direction kernel is the best kernel to fit WNV human case data, supporting the hypothesis of long-range WNV transmission is mainly along the migratory bird flyways. Through extensive simulation from 2014 to 2016, we proposed and tested hypothetical mitigation strategies and found that mosquito population reduction in the infected states and neighboring states is potentially cost-effective.

D.Phil. (Mathematical Statistics) / Fractional Brownian motion and its increment process, fractional Gaussian noise, are syn- onymous with the concept of long range dependence. A strictly stationary time series is said to exhibit long range dependence or long memory if its autocorrelations decrease to zero as a power of the lag, but their sum over all lags is not absolutely convergent. This phenomenon has been observed in numerous scientific areas such as hydrology, ethernet traffic data, stock returns and exchange rates, to name just a few. The extent of long memory dependence is characterized by the value of the so called Hurst exponent or Hurst coefficient H. Approximate normality and unbiasedness of the maximum likelihood estimate of H hold reasonably well for sample sizes as small as 20 if the mean and scale parameters are known. We show in a Monte Carlo study that if the latter two parameters are unknown, the bias and variance of the maximum likelihood estimate of H both increase substantially. We also show that the bias can be reduced by using a jackknife or parametric bootstrap proce- dure. However, in very large samples, maximum likelihood estimation becomes problematic because of the large dimension of the covariance matrix that must be inverted. We consider an approach for estimating the Hurst exponent by taking first order differ- ences of fractional Gaussian noise. We find that this differenced process has short memory and that, consequently, we may assume approximate independence between the estimates of the Hurst exponents in disjoint blocks of data. We split the data into a number of con- tiguous blocks, each containing a relatively small number of observations. Computation of the likelihood function in a block then presents no computational problem. We form a pseudo likelihood function consisting of the product of the likelihood functions in each of the blocks and provide a formula for the standard error of the resulting estimator of H. This formula is shown in a Monte Carlo study to provide a good approximation to the true standard error. Application of the methodology is illustrated in two data sets. The long memory property of a time series is primarily characterized by H. In general, such series are exceptionally long, therefore it is natural to enquire whether or not H remains constant over the full extent of the time series. We propose a number of tests for the hypothesis that H remains constant, against an alternative of a change in one or more values of H. Formulas are given to enable calculation of asymptotic p-values. We also propose a permutational procedure for evaluating exact p-values. The proposed tests are applied to three sets of data.

When an emerging outbreak occurs, stable parameter estimation and reliable projections of future incidence cases using limited (early) data can play an important role in optimal allocation of resources and in the development of effective public health intervention programs. However, the inverse parameter identification problem is ill-posed and cannot be solved with classical tools of computational mathematics. In this dissertation, various regularization methods are employed to incorporate stability in parameter estimation algorithms. The recovered parameters are then used to generate future incident curves as well as the carrying capacity of the epidemic and the turning point of the outbreak. For the nonlinear generalized Richards model of disease progression, we develop a novel iteratively regularized Gauss-Newton-type algorithm to reconstruct major characteristics of an emerging infection. This problem-oriented numerical scheme takes full advantage of a priori information available for our specific application in order to stabilize the iterative process. Another important aspect of our research is a reliable estimation of time-dependent transmission rate in a compartmental SEIR disease model. To that end, the ODE-constrained minimization problem is reduced to a linear Volterra integral equation of the first kind, and a combination of regularizing filters is employed to approximate the unknown transmission parameter in a stable manner. To justify our theoretical findings, extensive numerical experiments have been conducted with both synthetic and real data for various infectious diseases.

There exists a need to estimate the potential financial, epidemiological and societal impact that diseases, and the treatment thereof, can have on society. Markov processes are often used to model diseases to estimate these quantities of interest and have an advantage over standard survival analysis techniques in that multiple events can be studied simultaneously. The theory of Markov processes is well established for processes for which the process parameters are known but not as much of the literature has focussed on the estimation of these transition parameters. This dissertation investigates and implements maximum likelihood estimators for Markov processes based on longitudinal data. The methods are described based on processes that are observed such that all transitions are recorded exactly, processes of which the state of the process is recorded at equidistant time points, at irregular time points and processes for which each process is observed at a possibly different irregular time point. Methods for handling right censoring and estimating the effect of covariates on parameters are described. The estimation methods are implemented by simulating Markov processes and estimating the parameters based on the simulated data so that the accuracy of the estimators can be investigated. We show that the estimators can provide accurate estimates of state prevalence if the process is stationary, even with relatively small sample sizes. Furthermore, we indicate that the estimators lack good accuracy in estimating the effect of covariates on parameters unless state transitions are recorded exactly. The methods are discussed with reference to the msm package for R which is freely available and a popular tool for estimating and implementing Markov processes in disease modelling. Methods are mentioned for the treatment of aggregate data, diseases where the state of patients are not known with complete certainty at every observation and diseases where patient interaction plays a role. / Dissertation (MSc)--University of Pretoria, 2010. / Statistics / unrestricted