Orientador: Marilza Vieira Cunha Rudge / Resumo: Foi realizado estudo de coorte prospectiva para analisar a evolução dos achados eletromiográficos dos músculos do assoalho pélvico de gestantes com diabete melito gestacional entre 24-30 e 36-40 semanas gestacionais. O estudo foi conduzido no Centro de Investigação Clínica e Experimental do Diabete na Gestação da Faculdade de Medicina de Botucatu /UNESP com 52 gestantes divididas em dois grupos: (DMG) 26 gestantes com diabete melito gestacional e (NG) 26 gestantes normoglicêmicas. Foi realizado eletromiografia dos músculos do assoalho pélvico de nulíparas ou primíparas com cesariana prévia diagnosticadas com diabete melito gestacional da American Diabetes Association. Os critérios de não elegibilidade foram diabete clínico, mais de duas gestações, prolapso genitais ou cirurgia uroginecológicas, doenças neurológicas, exercício físico e tabagismo. Previamente a eletromiografia foi realizado instrução sobre a anatomia e funcionalidade do assoalho pélvico. Partes do protocolo de Glazer foram aplicadas entre 24-30 semanas gestacionais e reaplicadas entre 36-40 semanas gestacionais para analisar a evolução no recrutamento em repouso, nas contrações fásicas e tônica. O recrutamento foi analisado pelo cálculo do root mean square normalizado pelo pico das contrações fásicas entre 24-30 semanas gestacionais que foi considerado como parâmetro inicial de contração dos músculos do assoalho pélvico. Os dados demográficos e obstétricos demonstraram-se homogêneos entre os grupos. Em relação ... (Resumo completo, clicar acesso eletrônico abaixo) / Mestre

Orientador: Marilza Vieira Cunha Rudge / Resumo: Objetivo - Determinar a influência da via de parto na força muscular do assoalho pélvico (AP) de primíparas, 4 a 6 meses pósparto. Sujeitos e Métodos - Estudo clínico, de corte transversal, para avaliar a função da musculatura do AP pelo teste da AFA e perineômetro pneumático e classificada em: zero - ausência de contração muscular, um - contração leve, dois - contração moderada não sustentada por 6 segundos e, três - contração normal sustentada por 6 segundos. As 94 mulheres, tinham entre 20 e 30 anos, foram divididas em 3 grupos de acordo com a via de parto: I com 32 primíparas pós-parto vaginal; II com 32 primíparas pós-parto cesárea e III com 30 nulíparas que serviram como grupo controle. A variável independente foi a via de parto e a dependente a força muscular do AP(1). Resultados e conclusões - A mediana e o 1º e 3º quartís da força muscular do AP foram menores (p=0.01) pós-parto vaginal (2.0;1-2) e intermediária pós-parto cesárea (2.0; 2-3) em relação as nulíparas (3.0;2-3) pelo AFA e perineômetro. Aumentou o risco relativo(RR) de exame alterado da força da musculatura do AP pós-parto vaginal (RR=2.579 IC 95%=1.32-5.04 p=0.002); (RR=2.31 IC 95%=1.24- 4.32 p=0.005) e pós-cesárea (RR=1.56 IC 95% = 0.94-2.57 p=0.12); (RR=1.38 IC 95%=0.85-2.23 p=0.29) pela AFA e perineômetro. O parto vaginal diminuiu a força muscular do AP de primíparas e comparando com a cesárea e as nulíparas. / Abstract: Objective - To evaluate the influence of the route of delivery on pelvic floor (PF) muscle strength, in primiparous patients at 4 to 6 months after delivery. Subjects and methods - A cross-sectional study was undertaken among primiparous women at 4 to 6 months postpartum to evaluate the PF muscle strength by AFA test and pneumatic perineometer, classified in: zero - lack of muscle contraction; one - weak contraction; two - moderate contraction not sustained for 6 seconds and three - normal contraction sustained for 6 seconds. 94 enrolled patients were divided in three groups based upon prior delivery route: I) 32 vaginal delivery with singleton cephalic presentation; II) 32 cesarean delivery; and III) 30 nuliparous patients served as a control group. The independent variable was the route of delivery and the dependent one was the muscle strength of the PF. Data were subjected to Student t test to estimate the relative risk and the Kappa test(1). Results and conclusions - The three subgroups were comparable with respect to maternal age, weight, gestational age and newborn weight. The 1st and the 3rd quartiles of the route of delivery on PF muscle strength were lower (p=0.01) for vaginal delivery (n=32) (2.0;1- 2) and intermediate for cesarean (n=32) (2.0; 2-3) comparing to the nuliparous (3.0; 2-3) by AFA test and pneumatic perineometer. The altered PF muscle strength in primiparous were significantly lower in the vaginal delivery group (RR=2.58, CI 95%=1.32-5.04, p=0.002); (RR=2.31, CI 95%=1.24-4.32, p=0.005); and postcesarean (RR=1.56, CI 95% = 0.94- 2.57, p= 0.12); (RR=1.38, CI 95%=0.85-2.23, p=0.29). Vaginal delivery decreases PF muscle strength when compared with caesarean delivery and control. / Mestre

Resumo: Avaliar a prevalência de disfunções do assoalho pélvico após o tratamento de carcinoma invasor de colo uterino. Uma amostra de sessenta mulheres submetidas á histerectomia radical (n=20), radioterapia exclusiva (n=20) ou quimiorradiação (n=20) foram incluídas para análise. As funções de assoalho pélvico foram avaliadas por meio de questionários e avaliação física após, pelo menos, 6 meses do final do tratamento. A análise estatística realizada foram os testes de Mann-Whitney, kruskal-Wallis, Wilcoxon, Qui-quadrado quando apropriados. O p<0,05 foi considerado significativo. A idade variou de 28 a 75 anos (52,5 l 9,3 anos). O estádio clínico do tumor (FIGO) foi I em 25 casos (41,67%), II em 12 (20%), III em 22 (36,67%) and IV em 1 caso (1,67%). Os grupos foram semelhantes em relação a idade, paridade, menopausa e IMC. O comprimento vaginal foi menor em pacientes submetidas à radioterapia ou quimiorradiação quando comparadas com o grupo de histerectomia radical (5,5l1,9, 5,3l1,5 versus 7,4l1,1 cm, respectivamente; p<0,001). Não houve diferença em relação à incontinência urinária de esforço (p=0,56), urgência (p=0,44), urgeincontinência (p=0,54) e noctúria (p=0,53). Vida sexual ativa foi mais freqüente nas mulheres submetidas à cirurgia (90%) quando comparadas com o grupo da radioterapia (50%) e quimiorradiação (50%) (p=0,01). A dispareunia foi maior no grupo da radioterapia exclusiva, seguida da quimiorradiação e da histerectomia radical (p=0.021). O grupo da quimiorradiação apresentou maior freqüência evacuatória/dia (p<0.001) e a presença de diarréia foi menor no grupo da histerectomia radical (p=0.025), nos outros dois grupos foi semelhante. As disfunções do assoalho pélvico são comuns após o tratamento para carcinoma invasor de colo uterino. A radioterapia e a quimiorradiação são mais associadas às limitações... (Resumo completo, clicar acesso eletrônico abaixo) / Abstract: This study was undertaken to evaluate the prevalence of pelvic floor dysfunction following treatment for invasive carcinoma of the cervix. Sixty patients submitted to radical hysterectomy (n=20), radiotherapy (n=20) or chemoradiation (n=20) were included for analysis. Pelvic floor function was assessed by questionnaires and physical examination at least 6 months after the treatment has finished. Main outcome measures were urinary, intestinal and sexual functions and vaginal length. Data of patients were collected prospectively. Statistical analysis was performed using oe2 , Mann- Whitney, Kruskal-Wallis and Wilcoxon as appropriate. P-value< 0.05 was significantly. The age of patients ranged from 28 to 75 years old (52.5 l 9.3 years). Tumor staging (FIGO) was I in 25 cases (41.67%), II in 12 (20%), III in 22 (36.67%) and IV in 1 case (1.67%). Vaginal length was shorter in the patients submitted to radiotherapy or chemoradiation compared to radical hysterectomy group (5.5l1.9, 5.3l1.5 versus 7.4l1.1 cm; p<0.001). There were no differences regarding stress incontinence (p=0.56), urgency (p=0.44), urgeincontinence(p=0.54) and nocturia (p=0.53). Active sexual life was significantly higher in women submitted to surgical treatment (p=0.01), and dyspareunia was higher in the group of radiotherapy (p=0.021). The bowel frequency was higher in group of patients submitted to chemoradiation (p=0.025). Pelvic floor dysfunctions are common after treatment for invasive cervical carcinoma. Radiotherapy and chemoradiaiton are more associated to a limitation in sexual activity and bowel dysfunction than surgery. / Orientador: Agnaldo Lopes da Silva-Filho / Coorientador: Paulo Traiman / Banca: Jorge Nahás Neto / Banca: Sérgio Augusto Triginelli / Mestre

Perineal descent (PD) is a sign of connective tissue weakness of the pelvic floor, it can be measured mechanically or radiologically. Joint hypermobility can be a sign of a generalised connective tissue abnormality, there is an increased incidence of pelvic organ prolapse and faecal incontinence amongst patients with heritable connective tissues diseases. To explore the relevance of PD and the relationship between connective tissue abnormality and pelvic floor dysfunction five studies were performed.A new mechanical device for the measurement of PD, the laser commode, and the established mechanical device, the perineometer were compared to the current gold standard method of measurement, defaecating proctography in 68 subjects. The laser commode provided a mean overall PD measurement closer to that of proctography than the perineometer but the repeatability and reproducibility of the measurements were not accurate enough for the laser commode to be used either in the subsequent parts of this research project or in a clinical setting.Perineal descent was measured using proctography and joint hypermobility was measured using the Beighton score in 70 females with pelvic floor dysfunction. No correlation was found between PD and joint mobility.A review of 323 proctograms of females with pelvic floor dysfunction found an association between PD and rectal prolapse but no association between either PD and rectocele formation or PD and rectal intussusception. The Pelvic Floor Distress Inventory questionnaires of 133 females were correlated with their proctography findings. There was no association between PD and any of the clinical symptoms. Biopsies from the rectus sheath and pelvic floor fascia of 19 females with rectal prolapse were compared to those of 8 normal controls. There was no difference in collagen or elastin content between the groups but participant numbers were small. The pelvic floor fascia of the rectal prolapse group showed a higher percentage of well organised elastin than that of the control group but this did not reach statistical significance. Perineal descent does not appear to be a consistent indicator of severe pelvic floor connective tissue abnormality or injury. This study has furthered our understanding of perineal descent and the relationships between this finding and other pelvic floor disorders caused by connective tissue weakness. Future work will focus on further histological analysis of tissue from patients with rectal prolapse in combination with the use of more sensitive methods to establish the presence of an underlying connective tissue abnormality.

Strength and tone of the pelvic floor muscles are thought to play an important role in pelvic floor disorders, and are key outcomes monitored in pelvic floor rehabilitation, yet the standard approach to measuring these outcomes is through subjective assessment using manual palpation. While intravaginal dynamometers (IVD) have been designed to measure these characteristics in research settings, most are not sufficient to withstand the rigors of clinical use. This work presents the bench validation and subsequent updated design of a new mechanical constant speed mechanism for future inclusion in an IVD. Opening speeds of the original mechanism were validated with and without external loading using video analysis. The bench validation showed that the speed of arm opening was lower than the ranges specified for clinical use and was influenced by external loading. The mechanism was updated, and the bench test was repeated. The updated mechanism was found to provide output speeds that are within the ranges required clinically and were minimally impacted by external loading. The next step of this work is to reduce the size of the mechanism and improve output speeds to allow it to be assembled into a clinical prototype IVD.

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Diss. (sammanfattning) Stockholm : Karol. inst., 2004. / Härtill 5 uppsatser.

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Author of the Thesis: Bc. Andrea Matějková Supervisor of the Thesis: doc. Ing. Monika Šorfová, Ph.D. Title of the Thesis: Relation of function of the pelvic floor to respiration Year of the presentation of the thesis : 2016 Powered by TCPDF (www.tcpdf.org)

Thesis (Ph. D.)--University of Washington, 2001. / Vita. Includes bibliographical references (leaves 144-158).