Excess aluminum has been linked to such diseases as dialysis encephalopathy syndrome and osteodystrophy, in renal dialysis patients. Though the causality relation has not yet been confirmed, aluminum has also been associated with Alzheimer's disease. Aluminum is thought to be stored in bones, and a measure of its deposition should correlate with its total bioaccumulation. To date, only bone biopsies and desferrioxamine tests are available for such measurements. Neutron activation analysis (NAA) has been studied as a non-invasive technique for measuring bone aluminum. Two neutron beam ports from the McMaster nuclear reactor and the KN accelerator have been compared as possible thermal neutron sources. Resin-based phantoms, physiologically resembling a hand, were irradiated using the reactor based neutron source. From the results, a minimum detection limit (MDL) of aluminum in bone was obtained. An Andersson-Braun remmeter measured the dose delivered to the phantoms, due to the radiation exposure. The hand dose equivalent combined with the MDL, in this study, are compared to the results of previous NAA studies. The goal of this study is to measure low aluminum stores In Vivo, while delivering a low dose with respect to natural background levels. / Thesis / Master of Science (MS)

<p>Urbanization is an ongoing process all over the globe. People moving from rural to urban areas are the primary cause of urbanization, and history indicates that this movement of people is very hard to influence. The inflow of new residents to urban areas results in the need for more buildings and infrasystems, new institutions and often, new ways of life. How does this relate to the sustainability challenge? Given the ways in which most cities are currently developing, urbanization does not contribute to the achievement of sustainable development goals.</p><p>This thesis explores a new research strategy for studying the process of urbanization and how it may hold opportunities for addressing the long-term objectives of environmentally sustainable urban development. The research strategy: MAMMUT – Managing the Metabolism of Urbanization, is a methodological and conceptual framework, it is a dynamic and cross-disciplinary approach towards understanding urban sustainability.</p><p>The main novelty in this research strategy is to explore the use of <i>situations of opportunity</i> – instants when stakeholders have a possibility greater than average to guide and influence the urbanization process so as to contribute to more of environmental sustainability – as units of analysis. Political scientists have used concepts similar to this, however none is as wide in scope and time. Four aspects are analysed in a <i>situation of opportunity</i>: urban structure, institutional framework, new ways of life and environmental impacts – enhancing the cross-disciplinary approach of the framework. Also, in terms of time frame, the pre-history, the formative moment and the outcome of each situation are studied.</p><p>A cover essay and three papers compose this thesis. The papers apply and test the above-mentioned methodology in pilot studies about historical <i>situations of opportunity</i> created by the development of public transport systems in Stockholm, Dar es Salaam and Curitiba. The cover essay discusses the lessons learned with the pilot studies and aims at: (a) discussing and further developing the MAMMUT methodological and conceptual framework; (b) analysing the relations and synergies between the four aspects of urbanization (as proposed by MAMMUT’s framework).</p><p>The main conclusion of the thesis is that the MAMMUT research strategy can be a useful tool for analysing the urbanization process and its relations to sustainable development. Suggestions for improvements in the framework are made. Also, the four aspects of urbanization suggested for the analysis of a given <i>situation</i> are confirmed relevant, however the analysis of the relations and synergies between these aspects is revealed to be as important as studying the four aspects<i> per se.</i></p>

Urbanization is an ongoing process all over the globe. People moving from rural to urban areas are the primary cause of urbanization, and history indicates that this movement of people is very hard to influence. The inflow of new residents to urban areas results in the need for more buildings and infrasystems, new institutions and often, new ways of life. How does this relate to the sustainability challenge? Given the ways in which most cities are currently developing, urbanization does not contribute to the achievement of sustainable development goals. This thesis explores a new research strategy for studying the process of urbanization and how it may hold opportunities for addressing the long-term objectives of environmentally sustainable urban development. The research strategy: MAMMUT – Managing the Metabolism of Urbanization, is a methodological and conceptual framework, it is a dynamic and cross-disciplinary approach towards understanding urban sustainability. The main novelty in this research strategy is to explore the use of situations of opportunity – instants when stakeholders have a possibility greater than average to guide and influence the urbanization process so as to contribute to more of environmental sustainability – as units of analysis. Political scientists have used concepts similar to this, however none is as wide in scope and time. Four aspects are analysed in a situation of opportunity: urban structure, institutional framework, new ways of life and environmental impacts – enhancing the cross-disciplinary approach of the framework. Also, in terms of time frame, the pre-history, the formative moment and the outcome of each situation are studied. A cover essay and three papers compose this thesis. The papers apply and test the above-mentioned methodology in pilot studies about historical situations of opportunity created by the development of public transport systems in Stockholm, Dar es Salaam and Curitiba. The cover essay discusses the lessons learned with the pilot studies and aims at: (a) discussing and further developing the MAMMUT methodological and conceptual framework; (b) analysing the relations and synergies between the four aspects of urbanization (as proposed by MAMMUT’s framework). The main conclusion of the thesis is that the MAMMUT research strategy can be a useful tool for analysing the urbanization process and its relations to sustainable development. Suggestions for improvements in the framework are made. Also, the four aspects of urbanization suggested for the analysis of a given situation are confirmed relevant, however the analysis of the relations and synergies between these aspects is revealed to be as important as studying the four aspects per se. / QC 20101217

Yes / Background Buruli ulcer (BU) is an infectious disease caused by Mycobacterium ulcerans and considered the third most prevalent mycobacterial disease in humans. Secondary bacterial infections in open BU lesions are the main cause of pain, delayed healing and systemic illness, resulting in prolonged hospital stay. Thus, understanding the diversity of bacteria, termed the microbiome, in these open lesions is important for proper treatment. However, adequately studying the human microbiome in a clinical setting can prove difficult when investigating a neglected tropical skin disease due to its rarity and the setting. Methodology/Principal findings Using 16S rRNA sequencing, we determined the microbial composition of 5 BU lesions, 3 non-BU lesions and 3 healthy skin samples. Although no significant differences in diversity were found between BU and non-BU lesions, the former were characterized by an increase of Bacteroidetes compared to the non-BU wounds and the BU lesions also contained significantly more obligate anaerobes. With this molecular-based study, we were also able to detect bacteria that were missed by culture-based methods in previous BU studies. Conclusions/Significance Our study suggests that BU may lead to changes in the skin bacterial community within the lesions. However, in order to determine if such changes hold true across all BU cases and are either a cause or consequence of a specific wound environment, further microbiome studies are necessary. Such skin microbiome analysis requires large sample sizes and lesions from the same body site in many patients, both of which can be difficult for a rare disease. Our study proposes a pipeline for such studies and highlights several drawbacks that must be considered if microbiome analysis is to be utilized for neglected tropical diseases.

Family-centred service (FCS), which acknowledges the importance of family engagement in therapeutic processes and focuses on needs of all family members, is increasingly being recognized as an optimal care delivery model for families of children with developmental disabilities. However, services for families are oftentimes ‘child-centric’, wherein family members are seen as partners in therapy or care delivery only, while their own or family needs are not addressed. This arises from the lack of awareness of complex and highly individual family needs by professionals with whom they interact, but also from a significant lack of services oriented toward parent-specific needs in current delivery models. This thesis aims to address this knowledge gap and provides solutions for parental support in the context of pediatric developmental rehabilitation, which might also be applicable to other settings (e.g., community, education). The objectives of this thesis were: (a) to conduct a systematic review synthesizing randomized controlled trials aiming to address parents’ physical, psychological and socioeconomic well-being; (b) to perform cross-cultural and language adaptation and proof-of-concept pilot exploration of an innovative, strengths-based support program ‘ENabling VISions And Growing Expectation’ (ENVISAGE) for parents of children with neurodevelopmental disabilities in Croatia; (c) to refine the Croatian version of the program according to the pilot study results; (d) to run the first set of ENVISAGE workshops and evaluate their impact on Croatian parents’ perception of self, their child with a disability and their family; and (e) to learn about participants’ experience with the program. The findings show that interventions aiming to improve parents’ well-being have limited but promising effectiveness on parents’ health and well-being outcomes. ENVISAGE has proven to be a comprehensive, acceptable, usable, feasible and impactful program for parents of children with developmental disabilities in Croatia. / Dissertation / Doctor of Science (PhD) / Parents raising children with developmental disabilities have unique challenges in their parenting role, which might impact their health and well-being. However, there has been very little focus on parental and family needs in the context of pediatric developmental rehabilitation. Parents are often expected to focus on their child’s issues when their own support needs are usually also significant. This thesis aimed to address this research and practice gap through: a) evaluating best quality evidence on how to support parental well-being; and b) piloting a novel ‘early intervention’ support program for parents of children with disabilities, ‘ENabling VISions And Growing Expectation’ (ENVISAGE), in a new culture and language setting, Croatia. These findings have implications for spreading awareness of innovative programs to improve well-being of parents of children with developmental disabilities in various sectors (e.g., healthcare, community).