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Luminescent cyclometalated platinum(II) complexes : protein binding studies and biological applications /Siu, Kit-man, Phyllis. January 2005 (has links)
Thesis (Ph. D.)--University of Hong Kong, 2005.
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Non-covalent weak interactions in group IV, PT(II) and AU(I) organometallic complexes synthesis, structures and properties /Kui, Chi-fai. January 2005 (has links)
Thesis (Ph. D.)--University of Hong Kong, 2005. / Title proper from title frame. Also available in printed format.
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A study of the structural, microstructural and magnetic properties of iron-platinum and cobalt-platinum type nanoparticlesWang, Hongli. January 2007 (has links)
Thesis (Ph.D.)--University of Delaware, 2007. / Principal faculty advisor: George C. Hadjipanayis, Dept. of Physics & Astronomy. Includes bibliographical references.
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Investigation of transition metal-carbon bondsGoodfellow, R. J. January 1965 (has links)
No description available.
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Synthesis and characterization of novel platinum complexes : their anticancer behaviourMyburgh, Jolanda January 2009 (has links)
In this dissertation novel non-leaving groups were employed to synthesize platinum complexes which can contribute to the understanding or improvement of anticancer action. These complexes basically consist of (NS)-chelate and amineplatinum complexes. Bidentate (NS)-donor ligands were used as non-leaving ligands in the syntheses of platinum(II) complexes with iodide, chloride, bromide and oxalate anions as leaving groups. These complexes were synthesized and studied since many questions regarding the interaction of sulfur donors and platinum still exists. These relate to thermodynamic and kinetic factors and their influence on anticancer action. In this dissertation the properties of novel platinum(II) complexes of a bidentate ligand having an aromatic nitrogen-donor atom in combination with a thioethereal sulfur atom capable of forming a five membered ring with platinum(II) were studied. The general structure of the (NS) -ligands used were N-alkyl-2-methylthioalkyl imidazole. Alkyl groups used were methyl, ethyl and propyl. Although amine complexes of platinum have been extensively studied there are some new aspects of these that are worthwhile investigating. In this dissertation amines having planar attachments which will be at an angle with the coordination plane viz. benzylamine and amines having cyclic aliphatic groups namely cyclopropyl and cyclohexyl were investigated. Some of the (NS) - and amineplatinum(II) complexes were oxidised to their mononitroplatinum(IV) analogues . The motivation for the synthesis of these complexes was the greater kinetic stability of platinum(IV) and recent research has shown that a specific type of platinum(IV) compound shows suitable properties as an anticancer agent. These complexes were characterised by a variety of spectral means (IR, NMR, mass spectroscopy) as well as elemental analysis, solubility determinations, thermal analysis (TGA), ionization studies and finally their anticancer behaviour towards three different cell lines(Hela, MCF 7, Ht29) and in this process they were compared to the behaviour of cisplatin as a reference. A few have shown promising anticancer behaviour.
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Novel aspects of platinum-amine coordination compounds: their chemistry and anticancer applicationBouwer, Yolanda January 2008 (has links)
The aim in this thesis, was to synthesize novel platinum coordination compounds, in order to develop compounds with improved anticancer action which could lead to an improved understanding of the mechanism by which they operate and at the same time, improve synthetic methods for their products. The initial work included the development of a novel synthetic method for 1R,2R-diaminocyclohexaneoxalato-platinum(II) (oxaliplatin), by using an essentially non-aqueous solvent medium and direct ligand exchange at elevated temperatures. This was done by a study of the kinetics of the reaction in a variety of conditions; such as relative reagent concentrations and ratios as well as solvent mixtures. An effective method was developed which could be applied industrially. An international patent was taken out on this method. Various amine complexes of platinum(II) were synthesized using chloro, bromo and oxalato groups as leaving groups. The non-leaving groups were selected having certain specific characteristics in mind. Novel mononitroplatinum(IV) complexes were synthesized, mostly with oxalato leaving groups. One of these in particular, had excellent anticancer behaviour. Another trichloromononitro complex was also synthesized with very good anticancer properties. Two international patents were filed for the latter two compounds. As far as possible, all compounds were studied by spectrometric, chromatographic and thermal methods. They were also tested against 3 cancer cell lines namely cervical (Hela), Colon (HT29) and Breast (MCF7) cancer cells.
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Design and synthesis of novel classes of alkynyl-containing platinum (II) complexes as building blocks for supramolecular assemblies andhost-guest chemistryHui, Chi-kuen., 許志權. January 2003 (has links)
published_or_final_version / Chemistry / Doctoral / Doctor of Philosophy
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Non-covalent weak interactions in group IV, PT(II) and AU(I) organometallic complexes: synthesis,structures and propertiesKui, Chi-fai., 居智輝. January 2005 (has links)
published_or_final_version / abstract / Chemistry / Doctoral / Doctor of Philosophy
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Synthesis and luminescence studies of branched carbonrich platinum(II)and palladium(II) alkynyl complexes: versatile building blocks for multinuclear assembliesTao, Chi-hang., 陶志恆. January 2004 (has links)
published_or_final_version / Chemistry / Doctoral / Doctor of Philosophy
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Luminescent cyclometalated platinum (II) complexes in DNA binding studies and their cytotoxicities against carcinoma cell linesMa, Dik-lung, Edmond., 馬迪龍. January 2003 (has links)
published_or_final_version / Chemistry / Doctoral / Doctor of Philosophy
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