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Thèse numérisée par la Division de la gestion de documents et des archives de l'Université de Montréal.

Thèse numérisée par la Division de la gestion de documents et des archives de l'Université de Montréal

In order to understand biochemical networks we need to know not only how their parts work but also how they interact with each other. The goal of systems biology is to look at biological systems as a whole to understand how interactions of the parts can give rise to complex dynamics. In order to do this efficiently, new techniques have to be developed. This work shows how tools from mathematics are suitable to study problems in systems biology such as modeling, dynamics prediction, reverse engineering and many others. The advantage of using mathematical tools is that there is a large number of theory, algorithms and software available. This work focuses on how algebra can contribute to answer questions arising from systems biology. / Ph. D.

Quasi-hom-Lie algebras (qhl-algebras) were introduced by Larsson and Silvestrov (2004) as a generalisation of hom-Lie algebras, which are a deformation of Lie algebras. Lie algebras are defined by an operation called bracket, [·,·], and a three-term Jacobi identity. By the theorem from Hartwig, Larsson, and Silvestrov (2003), this bracket and the three-term Jacobi identity are deformed into a new bracket operation, <·,·>, and a six-term Jacobi identity, making it a quasi-hom-Lie algebra. Throughout this thesis we deform the Lie algebra sl2(F), where F is a field of characteristic 0. We examine the quasi-deformed relations and six-term Jacobi identities of the following polynomial algebras: F[t], F[t]/(t2), F[t]/(t3), F[t]/(t4), F[t]/(t5), F[t]/(tn), where n is a positive integer ≥2, and F[t]/((t-t0)3). Larsson and Silvestrov (2005) and Larsson, Sigurdsson, and Silvestrov (2008) have already examined some of these cases, which we repeat for the reader's convenience. We further investigate the following σ-twisted derivations, and how they act in the different cases of mentioned polynomial algebras: the ordinary differential operator, the shifted difference operator, the Jackson q-derivation operator, the continuous q-difference operator, the Eulerian operator, the divided difference operator, and the nilpotent imaginary derivative operator. We also introduce a new, general, σ-twisted derivation operator, which is σ(t) as a polynomial of degree k.