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  • About
  • The Global ETD Search service is a free service for researchers to find electronic theses and dissertations. This service is provided by the Networked Digital Library of Theses and Dissertations.
    Our metadata is collected from universities around the world. If you manage a university/consortium/country archive and want to be added, details can be found on the NDLTD website.

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Spelling suggestions: "subject:"polysialytransferases"" "subject:"polysialyltransferases""

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An optimised assay for quantitative, high-throughput analysis of polysialyltransferase activity

Elkashef, Sara M., Sutherland, Mark, Patterson, Laurence H., Loadman, Paul, Falconer, Robert A. 07 August 2016 (has links)
Yes / The polysialyltransferases are biologically important glycosyltransferase enzymes responsible for the biosynthesis of polysialic acid, a carbohydrate polymer that plays a critical role in the progression of several diseases, notably cancer. Having improved the chemical synthesis and purification of the fluorescently-labelled DMB-DP3 acceptor, we report optimisation and validation of a highly sensitive cell-free high-throughput HPLC-based assay for assessment of human polysialyltransferase activity.
Polysialytransferases
Glycosyltransferase enzymes
Polysialic acid
Carbohydrate polymers
Cancer
DMB-DP3 acceptor
Assay

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