The present investigation was conducted to determine the effect of an infection with Eimeria acervulina on vitamin A deficient birds. One hundred day-old chicks were divided into 2 equal groups, and one group was raised on 440 I.U. vitamin A per kilogram of feed, while the second group received the normally recommended 4400 I.U. per kilogram. At 5 weeks of age, half the birds from each group were given an immunizing infection with 3 million oocysts of E. acervulina. The clinical symptoms were more acute, and the oocyst production, mortality, and weight losses significantly higher, in the birds on the low vitamin A diet. When the birds were 9 weeks old, half were subjected to a second infection and the other half held until they were 19 weeks old. The 9-week-old birds were given an oral inoculation of 10 million oocysts to evaluate the effect of a low vitamin A diet on: the strength of the immune response; a primary infection with E. acervulina in 9-week-old birds; and the early tissue stages of the parasite in immune and non-immune birds. The results from this experiment showed that the degree of immunity is not affected by a low vitamin A ration, but primarily determined by the severity of the initial infection; and that the primary infection in 9-week-old chicks is clinically very similar to that in younger birds. The histological examinations demonstrated that the low vitamin A level used in this study did not affect the integrity of the intestinal epithelium, nor the development of the endogenous forms of the parasite. It was also shown that the sporozoite invasion was the same in immune and non-immune birds, but the schizont development was severely inhibited in the immune birds regardless of the vitamin A level. The non-immune birds on the low vitamin A ration did not show as distinct a heterophil response to infection as did the other groups. The remaining birds, half which were immunized, were maintained on their respective diets until 19 weeks of age, and during this period there was no clinical evidence of a vitamin A deficiency, and the growth rate was not significantly affected by the level of vitamin A in the diet. When 19 weeks old, the birds were inoculated with 25 million oocysts of E. acervulina to assess the effect of an extremely heavy primary infection in older birds, and to evaluate the degree of immunity still retained 14 weeks after an initial infection. The mortality was very high, and the weight losses significantly greater, in birds on the low vitamin A dietary level. Immunity, although decreased from the earlier experiment, was still present in birds on both levels of vitamin A. / Land and Food Systems, Faculty of / Graduate

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Call number: LD2668 .T4 1959 J66

Call number: LD2668 .T4 1961 Z54

Call number: LD2668 .T4 1963 H35 / Master of Science

Assignment (MPhil)--University of Stellenbosch, 2004. / ENGLISH ABSTRACT: The aim of this study was to evaluate the performance and profitability of different dietary specifications for broiler chickens slaughtered at 35 days of age. Two trials were performed to evaluate different production parameters. The results of these trials were compared to the predicted results of the EFG broiler model. No carcass data were available for the two trials mentioned above. Therefore, in order to evaluate the accuracy of the broiler model when predicting carcass characteristics, two published data sets (Leeson et al., 1996a) were used. Predicted and actual values were compared, evaluated and discussed. Two broiler trials were performed. In Trial One the amino acid density decreased throughout the range of three treatments from prestarter to finisher diets. In Trial Two the amino acid density decreased only in the four finisher diets. The main difference between predicted and actual results was the response to body weight. The model predicted a steady increase in feed intake to compensate for the lower dietary specifications while body weight did not change significantly. This increase in feed intake seems to be enough to maintain body weight. Trial birds also increased their feed intake as dietary amino acid density decreased, but this compensation seemed to be too low to maintain body weight compared to the control diet. The birds may find it easier to compensate when they have time to adapt to the specification. There is evidence in the literature that birds need seven days to adapt their feed intake to a lower feed specification (Leeson et al., 1996a). It can be speculated that the trial birds started to loose body weight due to a lower amino acid intake in this period. The model seems to adapt feed intake immediately after a change in diet specification. The simulation on literature data lead to the following conclusions: 1) Broilers posses the capacity to increase their feed intake with at least 65% should finisher diets with lower amino acid and energy concentrations be supplied. If only the energy concentration of finisher diets were decreased, the increase in feed intake will be around 30%. (see Table 16 and 23) 2) The accurate prediction of feed intake from the given dietary specification has a major influence on the accuracy of the prediction of broiler performance. 3) Amino acid density and DLys:ME ratio plays a significant role in the control and prediction of feed intake. The EFG broiler model is based on sound scientific principles. The model is comprehensive and can be used for a wide range of environmental and management conditions as well as dietary conditions. The nutritionist can use the model with confidence to assist in practical feed formulation. The actual strength of the model lies in the time and money being saved compared to practical trials. / AFRIKAANSE OPSOMMING: Die doel van hierdie studie is om die prestasie en winsgewendheid van braaikuikens te bepaal wanneer voere met verskillende digthede tot op 35 dae gevoer word. Twee eksperimente is uitgevoer om produksieresultate te evalueer. Die resultate van hierdie eksperimente is met die voorspelde waardes uit die EFG simulasie-model vergelyk. Aangesien geen karkasdata vir bogenoemde eksperimente beskikbaar was nie, is twee gepubliseerde datastelle gebruik om hierdie deel van die model te evalueer (Leeson et al., 1996a). Twee braaikuiken eksperimente is uitgevoer. Eksperiment Een het uit drie behandelings bestaan waarvan die aminosuur-konsentrasie vanaf dag een tussen behandelings verskil het. In Eksperiment Twee het die aminosuur-konsentrasie net in die vier afrondingsdiëte verskil. Liggaamsmassa op 35 dae het die grooste verskil tussen voorspelde- en werklike waardes getoon. Beide voorspelde en werklike innames het in albei eksperimente verhoog soos wat aminosuur-konsentrasie afgeneem het. Voorspelde liggaamsmassa het egter konstant gebly terwyl werklike data 'n afname in liggaamsmassa getoon het. Dit bleik dat die voorspelde toename in innames voldoende was om massa te onderhou terwyl die voëls in werklikheid nie genoeg gekompenseer het nie. Leeson et al., 1996a het tot die gevolgtrekking gekom dat braaikuikens minstens sewe dae benodig om hul voeriname by 'n nuwe spesifikasie aan te pas. So 'n stadige aanpassing kan daartoe lei dat energie- en aminosuur-inname daal indien 'n dieet met laer spesifikasie gevoer. Dit sal daartoe lei dat die kuikens liggaamsmassa verloor. Uit die literatuur simulasies is die volgende afleidings gemaak: 1) Braaikuikens besit die vermoeë om voerinname in die afrondingstyd met minstens 65% te verhoog indien 'n afrondingvoer met laer amiosuur- asook energiekonsentrasie gevoer word. Indien net die energiekonsentrasie verlaag word, sal die inname met sowat 30% verhoog. 2) Die akkurate voorspelling van inname is krities vir die akkurate voorspelling van produksieparameters. 3) Aminosuur-digtheid en DLys:ME speel 'n belangrike rol in die beheer en voorspelling van voerinname by braaikuikens. Die EFG braaikuikenmodel is op suiwer wetenskaplike beginsels geskoei. Die model is omvattend en kan vir 'n wye reeks van omgewings- en bestuurstoestande asook dieet-spesifikasies gebruik word. Die voedingkundige kan die model met vertroue gebruik om met praktiese voerformulering by te staan. Die model kan die formuleerder baie tyd spaar aangesien praktiese eksperimente ingeperk kan word.

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Call number: LD2668 .T4 1957 P63 / Master of Science

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