Made available in DSpace on 2014-12-17T14:55:23Z (GMT). No. of bitstreams: 1 RonaldoAM.pdf: 2082162 bytes, checksum: 2dd11d30b856b23cf429317a1e68bfbe (MD5) Previous issue date: 2006-06-12 / In this dissertation new models of propagation path loss predictions are proposed by from techniques of optimization recent and measures of power levels for the urban and suburban areas of Natal, city of Brazilian northeast. These new proposed models are: (i) a statistical model that was implemented based in the addition of second-order statistics for the power and the altimetry of the relief in model of linear losses; (ii) a artificial neural networks model used the training of the algorithm backpropagation, in order to get the equation of propagation losses; (iii) a model based on the technique of the random walker, that considers the random of the absorption and the chaos of the environment and than its unknown parameters for the equation of propagation losses are determined through of a neural network. The digitalization of the relief for the urban and suburban areas of Natal were carried through of the development of specific computational programs and had been used available maps in the Statistics and Geography Brazilian Institute. The validations of the proposed propagation models had been carried through comparisons with measures and propagation classic models, and numerical good agreements were observed. These new considered models could be applied to any urban and suburban scenes with characteristic similar architectural to the city of Natal / Nesta tese novos modelos de predi??o de perda de percurso de propaga??o s?o propostos a partir de t?cnicas de otimiza??es recentes e de medi??es de n?veis de pot?ncias obtidas para as ?reas urbana e suburbana de Natal, cidade do Nordeste Brasileiro. Estes novos modelos s?o: (i) um modelo estat?stico que foi implementado baseado na adi??o de estat?sticas de 2a. ordem para a pot?ncia e a altimetria do relevo ao modelo de perdas lineares; (ii) um modelo com redes neurais artificiais que usou o treinamento do algoritmo backpropagation, a fim de obter a equa??o de perdas de propaga??o; (iii) um modelo baseado na t?cnica dos trajetos aleat?rios, que considera a aleatoriedade da absor??o e do caos do meio ambiente e que seus par?metros desconhecidos para a equa??o de perdas de propaga??o s?o determinados atrav?s de uma rede neural. A digitaliza??o do relevo das ?reas urbanas e suburbanas de Natal foi realizada atrav?s do desenvolvimento de programas computacionais espec?ficos e foram usados os mapas existentes no Instituto Brasileiro de Geografia e Estat?stica. As valida??es dos modelos propostos de predi??o de perda de propaga??o foram realizadas atrav?s de compara??es com medidas e modelos cl?ssicos de propaga??o, obtendo-se boas concord?ncias num?ricas. Estes novos modelos poder?o ser aplicados a qualquer cen?rio urbano e suburbano com caracter?sticas arquitet?nicas semelhantes ? cidade de Natal

The diploma thesis is focused on evaluating the performance of the company KOHUT Třinec s.r.o. in period from 1. 4. 2007 to 31. 3. 2011. Evaluation is made by using selected indicators of financial analysis, namely pyramidal decompositions and systems of purposefully selected indicators. The theoretical part contains the definition of basic concepts for understanding the issues examined. Based on financial analysis in the practical section are made possible suggestions to improve the current situation of the company and suggestions to remove the identified problems.

In der Arbeit wird eine Methodik einer zusammenhängenden Analyse und modellhaften Beschreibung der Verkehrssicherheit in städtischen Hauptstraßennetzen am Beispiel der Stadt Dresden entwickelt. Die dabei gewonnenen Modelle dienen der Abschätzung von Erwartungswerten von Unfallhäufigkeiten mit und ohne Personenschaden unter Berücksichtigung der Verkehrsbeteiligungsart. Die Grundlage bilden multivariate Regressionsmodelle auf Basis verallgemeinerter linearer Modelle (GLM). Die Verwendung verallgemeinerter Regressionsmodelle erlaubt eine Berücksichtigung von Verteilungen, die besser geeignet sind, den Unfallentstehungsprozess wiederzugeben, als die häufig verwendete Normalverteilung. Im konkreten Fall werden hierzu die Poisson-Verteilung sowie die negative Binomialverteilung verwendet. Um Effekte im Hauptverkehrsstraßennetz möglichst trennscharf abbilden zu können, werden vier grundsätzliche Netzelemente differenziert und das Netz entsprechend zerlegt. Unterschieden werden neben Streckenabschnitten und Hauptverkehrsknotenpunkten auch Annäherungsbereiche und Anschlussknotenpunkte. Die Kollektive der Knotenpunkte werden ferner in signalisierte und nicht-signalisierte unterteilt. Es werden zunächst Modelle unterschiedlicher Unfallkollektive getrennt für alle Kollektive der vier Netzelemente berechnet. Anschließend werden verschiedene Vorgehensweisen für eine Zusammenfassung zu Netzmodellen entwickelt. Neben der Verwendung verkehrstechnischer und infrastruktureller Größen als erklärende Variable werden in der Arbeit auch Kenngrößen zur Beschreibung der Umfeldnutzung ermittelt und im Rahmen der Regression einbezogen. Die Quantifizierung der Umfeldnutzung erfolgt mit Hilfe von Korrelations-, Kontingenz- und von Hauptkomponentenanalysen (PCA). Im Ergebnis werden Modelle präsentiert, die eine multivariate Quantifizierung erwarteter Unfallhäufigkeiten in Hauptverkehrsstraßennetzen erlauben. Die vorgestellte Methodik bildet eine mögliche Grundlage für eine differenzierte Sicherheitsbewertung verkehrsplanerischer Variantenabschätzungen. / A methodology is developed in order to predict the number of accidents within an urban main road network. The analysis was carried out by surveying the road network of Dresden. The resulting models allow the calculation of individual expectancy values for accidents with and without injury involving different traffic modes. The statistical modelling process is based on generalized linear models (GLM). These were chosen due to their ability to take into account certain non-normal distributions. In the specific case of accident counts, both the Poisson distribution and the negative binomial distribution are more suitable for reproducing the origination process than the normal distribution. Thus they were chosen as underlying distributions for the subsequent regressions. In order to differentiate overlaying influences, the main road network is separated into four basic elements: major intersections, road sections, minor intersections and approaches. Furthermore the major and minor intersections are additionally subdivided into signalised and non-signalised intersections. Separate models are calculated for different accident collectives for the various types of elements. Afterwards several methodologies for calculating aggregated network models are developed and analysed. Apart from traffic-related and infrastructural attributes, environmental parameters are derived taking into account the adjacent building structure as well as the surrounding land-use, and incorporated as explanatory variables within the regression. The environmental variables are derived from statistical analyses including correlation matrices, contingency tables and principal components analyses (PCA). As a result, a set of models is introduced which allows a multivariate calculation of expected accident counts for urban main road networks. The methodology developed can serve as a basis for a differentiated safety assessment of varying scenarios within a traffic planning process.

<p dir="ltr">The genetic perturbations caused by spaceflight on biological systems tend to have a system-wide effect which is often difficult to deconvolute into individual signals with specific points of origin. Single cell multi-omic data can provide a profile of the perturbational effects but does not necessarily indicate the initial point of interference within a network. The objective of this project is to take advantage of large scale and genome-wide perturbational or Perturb-Seq datasets by using them to pre-train a generalist machine learning model that is capable of predicting the effects of unseen perturbations in new data. Perturb-Seq datasets are large libraries of single cell RNA sequencing data collected from CRISPR knock out screens in cell culture. The advent of generative machine learning algorithms, particularly transformers, make it an ideal time to re-assess large scale data libraries in order to grasp cell and even organism-wide genomic expression motifs. By tailoring an algorithm to learn the downstream effects of the genetic perturbations, we present a pre-trained generalist model capable of predicting the effects of multiple perturbations in combination, locating points of origin for perturbation in new datasets, predicting the effects of known perturbations in new datasets, and annotation of large-scale network motifs. We demonstrate the utility of this model by identifying key perturbational signatures in RNA sequencing data from spaceflown biological samples from the NASA Open Science Data Repository.</p>