Reproduction de : Thèse de doctorat : Langues, histoire et civilisations des mondes anciens : Lyon 2 : 2004. / Titre provenant de l'écran-titre. Bibliogr. Catalogue.

Reproduction de : Thèse d' exercice : Médecine spécialisée : Nancy 1 : 2002. / Thèse : 2002NAN11074. Titre provenant de l'écran-titre.

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CNS-PNETs are rare, aggressive, paediatric embryonal brain tumours that are poorly studied. We recently identified an aggressive sub-group of CNS-PNETs characterized by the amplification of the C19MC microRNA cluster, however, little is known regarding the features of other CNS-PNET tumours. This study was designed to define additional molecular sub-groups of CNS-PNET by interrogating a large cohort of CNS-PNETs. To elucidate the features of CNS-PNET, we examined transcriptional and copy number profiles from primary hemispheric CNS-PNETs. We then validated and examined the clinical significance of novel sub-group markers in 123 primary CNS-PNETs. This thesis demonstrates that CNS-PNET can be categorized into three molecular sub-groups that are distinguished by distinct primitive neural, oligo-neural and mesenchymal lineage gene expression signatures and also correlated with distinct clinical features. Data from my thesis has generated a substantial body of knowledge to fuel both biological and clinical investigations of childhood CNS-PNETs.

CNS-PNETs are rare, aggressive, paediatric embryonal brain tumours that are poorly studied. We recently identified an aggressive sub-group of CNS-PNETs characterized by the amplification of the C19MC microRNA cluster, however, little is known regarding the features of other CNS-PNET tumours. This study was designed to define additional molecular sub-groups of CNS-PNET by interrogating a large cohort of CNS-PNETs. To elucidate the features of CNS-PNET, we examined transcriptional and copy number profiles from primary hemispheric CNS-PNETs. We then validated and examined the clinical significance of novel sub-group markers in 123 primary CNS-PNETs. This thesis demonstrates that CNS-PNET can be categorized into three molecular sub-groups that are distinguished by distinct primitive neural, oligo-neural and mesenchymal lineage gene expression signatures and also correlated with distinct clinical features. Data from my thesis has generated a substantial body of knowledge to fuel both biological and clinical investigations of childhood CNS-PNETs.

During the period of 1992-1998, Russia underwent a transition from a centralized economy to a market economy with devastating socioeconomic consequences, and industrial decline, which has resulted in demographic crises. The central argument driving this thesis is that during its transition to a market economy, through shock therapy from 1992-1998, Russia’s social and economic infrastructure went through a regression in the form of refeudalization, which is empirically revealed through health and demographic indicators. Remarkably, the effects of this socioeconomic regression was buffered from further devastation through a set of social compromises between workers, unions and industrial managers, which stabilized the brunt of shock therapy, but still resulted in the refeudalization of Russian society. The objective of this study is to construct a comprehensive model to conceptualize Russia’s socioeconomic regression during the period of transition from 1992-1998, and to explain the causes for the regression within the model. / This thesis conceptualizes socioeconomic regression as a feature of political economy within a mode of production model, and applies the model to explain Russia's socioeconomic transition during the period from 1992 to 1998.

The early Christian text known as the 'Letter to the Hebrews' has presented a riddle to scholarship. Its anonymity and anomalous form are puzzling. Scholars like Norman Perrin and Barnabas Lindars also-find Hebrews enigmatic because it does not appear to represent the views of any early Christian community. / This thesis contends that the riddle of Hebrews' lack of community-fit is due to a conceptual flaw. Beginning with Franz Overbeck (1882), there has been a tendency to assess early Christian texts as nonliterary, unlike later Patristic texts. Deemed nonliterary, they are thereby thought to document the situation within which they were written. For Hebrews, this has resulted in numerous reconstructions of its historical setting. None, however, has proven satisfactory. This lack of consensus casts doubt on the appropriateness of ruling out Hebrews' essential literary character. Moreover, the explanations used to justify the unique nonliterary character of early Christian literature are not compelling. Thus, the probability of Hebrews' literary character increases. / The literary texts written by Irenaeus, Clement of Alexandria, and Tertullian, are more likely comparable to Hebrews. These Patristic texts were produced in the late second century before the shape of orthodoxy became fixed. A survey of representative scholarly literature shows a low expectation of retrieving from these early Patristic texts an unambiguous profile of the author's ideological community, of the text's occasion, or of its audience. Thus, it would be unwarranted to expect Hebrews to be more representative of its situation. / Given the probability of Hebrews' literary character, the thesis demonstrates that it is inappropriate to assume that Hebrews represents ideas that extend beyond those of the author to a specific community or to a particular situation. The burden of proof is reversed. Without evidence to the contrary, Hebrews is best explained as a persuasive literary effort by an idiosyncratic author directed to a general Christian audience. / Thus, the riddle of Hebrews' lack of community-fit dissolves. Furthermore, questions are raised regarding the contemporary scholarly expectation that other early Christian writings (Matthew, James, etc.) were shaped by and for ideologically distinct communities.