Research has suggested that the Five Factor Model (FFM) is useful in describing personality pathology as well as personality traits. However, there appears to be disproportionate implications of the five domains for problems in living. Previous empirical research concerning the differential direction and magnitude of the relationship of the FFM domains to problems in living and personality disorder symptomatology has perhaps been limited in part by the use of a measure of the FFM that itself includes a disproportionate representation of maladaptive personality functioning across the domains. The current study also tests the hypothesis that the relationship of the FFM domains to problems in living parallels the definition of personality disorder as provided in the American Psychiatric Association’s (2000) diagnostic manual, concerning social impairment, occupational impairment, and distress. These hypotheses were tested in a sample of 79 persons who were within psychiatric treatment. The current study indicated that problems in living relate to the FFM domains in a meaningful manner and that these relationships correspond to the definition of personality disorder. Implications of the findings for future research are discussed.