The application of the wrinkle measuring method described in Müller et al. (2017) and the subsequent evaluation algorithm of a range of deep-drawn samples were used to determine the influences and interdependencies of blankholder force, tool temperatures, and drawing height on the formation of wrinkles in paperboard. The main influences were identified and quantitatively evaluated. For the given experimental space, a regression function was derived and validated in further experiments. It was shown that a quadratic regression was superior to the previously used linear regression. The findings were discussed and compared with the results of similar experiments from past publications. Special attention was given to the wrinkles formed and the resulting quality of the formed paperboard cups. The restrictions of the data acquisition from the measuring method that was used and limitations of the model were presented to demonstrate the reliability of the results.

[pt] Sepse é considerada uma carga na saúde e na economia global. No Brasil, a sepse é a principal causa de morte em Unidades de Terapia Intensiva, bem como uma das principais causas de mortalidade hospitalar tardia. Nesta tese, inicialmente apresenta-se um relatório epidemiológico brasileiro de sepse contemplando 10 anos utilizando dados do Sistema Único de Saúde (SUS). Em seguida, mostra-se um estudo que apoia os estabelecimentos de saúde na avaliação e otimização de seus protocolos clínicos de sepse usando técnicas de mineração de processos. Um protocolo clínico consiste em um plano de cuidados bem definido, que inclui uma ordem clara e tempo para a execução de intervenções com resultados esperados. Durante a execução deste estudo, identificou-se a falta de técnicas de mineração de processos para a otimização de protocolos clínicos. Assim, neste trabalho foi proposta, implementada e testada uma nova técnica de mineração de processos que auxilia usuários na otimização de seus processos. Esta técnica foi aplicada para a melhoria de protocolos clínicos. A técnica desenvolvida (Multi-CAT) identifica e destaca um conjunto de atividades e subsequências que promovem resultados positivos ou negativos, considerando múltiplos critérios simultâneos. A técnica foi aplicada com sucesso em um protocolo clínico de sepse, na qual foram adquiridas mais recomendações de otimização do que foi previamente obtido em análise manual. Conclui-se que a técnica desenvolvida apresenta grande potencial para auxiliar na otimização de processos com bom desempenho. No cenário de testes mais complexo, com 58 atividades, 50.000 casos e 14.451 variantes, Multi-CAT utilizou 2,04 minutos para executar a análise. Para finalizar, a ferramenta foi validada em dois processos distintos, indicando potencial para ser aplicada em outras áreas de negócio. / [en] Sepsis is considered a worldwide health and economic burden. In Brazil, sepsis is the major cause of death in Intensive Care Units, as well as, one of the main causes of late hospital mortality. In this thesis, we first provide a 10 years population-level epidemiology report of sepsis in Brazil, using data from the Brazilian Unified Health System. Secondly, we present a research study that supports health care facilities in the evaluation and optimization of their sepsis clinical pathways (CP) using process mining techniques. A CP consists of a well-defined care plan, which includes a clear order and time for the execution of interventions with expected outcomes. During the execution of this study, it became clear for us the lack of existing process mining techniques for the optimization of CPs. Thus, we proposed, implemented and tested a novel process mining technique that supports users to improve their processes and we applied it for CP improvement. Our developed technique (Multi-CAT) identifies and highlights a set of activities and sub-sequences that provide positive or negative outcomes considering multiple simultaneous criteria. We successfully applied our technique in a real sepsis CP, and we acquired more optimization insights that we got in our previous manual analysis. We conclude that Multi-CAT has high potential to help in the optimization of processes with a good performance. In the most complex test scenario, with 58 activities, 50,000 cases and 14,451 variants, Multi-CAT took 2.04 minutes to execute the analysis. Finally, the tool was validated in two different processes, indicating potential capability to be applicable to other business areas.

The aim was to analyze processes selected SMEs (small and medium enterprises) and to suggest possible improvements in the selection processes. In the initial stage, I deal with study of professional literature Czech and foreign authors. I used the information to write a review of the literature. The Part of my work is devoted to the description of the company and also describe the key processes. The findings gave me the possibility of a comprehensive perspective on the issue and used to create a design of the possible improvements in selected processes.

Made available in DSpace on 2016-06-02T19:56:47Z (GMT). No. of bitstreams: 1 4341.pdf: 3523829 bytes, checksum: c8f8e2af0018506bb783b5898011090f (MD5) Previous issue date: 2012-03-29 / Universidade Federal de Sao Carlos / Fructose (C6H12O6) is a monosaccharide with increasing industrial interest, and with some advantages over other sugars, facts that have motivated many studies about its production from its aqueous solution, by crystallization. Fructose crystallization occurs, in general, with the addition of ethanol as anti-solvent, aiming the reduction of its solubility and metastable zone width. Addition of ethanol makes feasible fructose crystallization, however, generates other negative factors to the process, as economically, because of its cost, as environmentally, because of the generation of the mother-liquor as a highly concentrate ethanol residue. These factors motivated the study of separation and reuse of the mother-liquor, recycling both ethanol and the diluted solution of non-crystallized fructose back to the process. Besides, the process was integrated into the calcium gluconate enzymatic production, through the reuse of its byproduct as raw material of the process of this work. Because of the absent of experimental data in literature, some methods of calculation of the vapor-liquid equilibrium (VLE) of the ternary solution were tested and compared, providing the choice of some of them to determine the equilibrium data. The method which obtained the best results was the AUNIFAC, and this method was used to provide the energy calculations of the process, by the evaporation and distillation temperature calculations. The cost of energy together with the replaced ethanol, were used to determine the operational cost, allowing the comparison of different operational conditions of the global process. With temperatures above 100°C in laboratorial experiments, the solution became yellow, a behavior of fructose caramelisation. It can occur because of the thermal degradation of fructose producing hydroxymethylfurfural and it prejudices the crystallization process. Because of it, it is necessary to avoid temperatures above 100°C. Finally, the integrated process made feasible crystalline fructose production by crystallization. / A frutose (C6H12O6) é um monossacarídeo com crescente interesse industrial e algumas vantagens quando comparado a outros açúcares, fatos que tem motivado estudos de sua produção a partir da solução aquosa, via cristalização. A cristalização de frutose ocorre, comumente, com a adição de etanol como antissolvente, visando a diminuição de sua solubilidade e da largura da zona metaestável. A adição de etanol à solução viabiliza a cristalização, entretanto, gera fatores negativos ao processo, tanto economicamente, por agregar custo ao processo, quanto ambientalmente, pela geração do licor-mãe como um resíduo altamente concentrado em etanol. Tais fatores motivaram o estudo de um processo integrado com separação, via destilação, e reuso do licor-mãe da cristalização, reaproveitando tanto o etanol quanto a solução aquosa diluída de frutose não cristalizada. O processo foi integrado também ao processo produtivo de gluconato de cálcio, utilizando como matéria-prima um subproduto de tal processo. No estudo da destilação da solução ternária, devido à ausência de dados de equilíbrio líquido-vapor (ELV) na literatura, foram estudados métodos de obtenção do equilíbrio, métodos estes que foram testados e comparados para avaliação da possibilidade de utilização dos mesmos. O método que obteve melhores resultados, o A-UNIFAC, foi utilizado nos cálculos das temperaturas das operações de evaporação e destilação, possibilitando os cálculos das energias envolvidas no processo via balanços de energia. Tais energias, bem como o etanol reposto no processo, foram utilizadas para determinação do custo de operação da planta, possibilitando a comparação de diferentes de operação do processo. A partir de ensaios em laboratório, notou-se a formação de cor amarelada, característica de caramelização da frutose em temperaturas acima de 100°C. Tal característica pode ter ocorrido pela desidratação da frutose formando o hidroximetilfurfural e mostrou-se prejudicial à cristalização sendo necessário, portanto, evitar temperaturas acima de 100°C em todo o processo. O processo integrado viabilizou a produção de frutose cristalina por cristalização.

The work deals with Process Management and its influence on efficiency and productivity of companies. By remodeling of processes, it is possible to ensure more fluent and easier production. An essential tool for labour analysis was Structured Process Analysis.

Neste trabalho, foi estudado o desempenho de um sistema constituído de torres de resfriamento e a sua integração em uma planta industrial de hidrogenação de butadieno. Caracterizou-se o desempenho das torres de resfriamento com base em um modelo fenomenológico, cujos parâmetros foram obtidos a partir da medição de variáveis operacionais reais. O processo de hidrogenação foi configurado em um simulador de processos, sendo o caso base estabelecido nas condições de projeto. Elaborou-se um módulo específico referente às torres de resfriamento, que foi integrado ao processo configurado no simulador. Em seguida, analisaram-se as interações das condições operacionais da torre de resfriamento no desempenho do processo industrial. / In the present work, the performance of a system composed of a cooling tower integrated in butadiene hydrogenation plant was studied. An experimental investigation was made to characterize the cooling towers based on a phenomenological model and in real process conditions. The hydrogenation process was configured on a process simulator and design specifications were considered as base case. A cooling tower module was developed and integrated to the process simulator. The interaction of the cooling tower system and the plant operation was investigated.

The topic of this thesis is to optimize the production process of ferrite cores in the company Epcos, Ltd. The work is divided into theoretical, analytical and design part. The first part of the thesis contains theoretical knowledge within the field of lean manufacturing, process mapping and mapping value streams. Based on these findings is determined the theoretical basis for the processing of other parts of the thesis. The aim of the analytical part of the analysis is to map the current state of the manufacturing process, finding bottlenecks, evaluating the results of analysis of the current state, which will be used for the design part of the thesis, to develop proposals for optimizing production bottlenecks and evaluate their contribution.

The thesis focuses on the creation of functional requirements for an information system based on process analysis of an organization. In the theoretical part introduces the reader to the basic concepts related to business processes, their modeling and relationship with the company information system. Then, two approaches to analysing the functioning of the organization are presented, namely the approach of consultancy company Logio and the MMABP methodology. The practical part describes a real project of process analysis and creation of functional requirements for IS of a trading company. The MMABP approach is then applied to the same company. In conclusion, suitability of both approaches is evaluated and observed differences between them are identified.

This theses mainly focuses on development of information system for a facility management company. It explores processes in the property management business and possibilities of its facilitation by software applications that are mainly within the tasks of a technical nature. The origin of the paper lies in the process analysis of Vaše domy Ltd. which had been started earlier on. The thesis follows up with more detailed study of client request processing. The goals of the paper are: specifying company's requirements for an application software, analysing the current market situation in the field and finally it covers design and implementation of a unique software solution.

Master thesis called "Business processes reengineering in an integrated information system and the e-commerce application" proves the hypothesis that the key to successful internet business is to have correctly set the process management of a company, which, through an automated connection, displayed externally for customers through the presentation layer of the e-commerce application. The results are useful for owners of eshops, for their conception of setting up the operations of their companies and especially for the company, where the analysis was performed. According to selected company Penny Ltd., this analysis sets for its eshop Elektro-partner.cz twenty elementary processes, whose implementation will lead to saving staff time, maximum use of the information system including the possibility of implementing new modules, setting up workflow processes and possibility to make a profit and higher customer satisfaction. In the theoretical part are marketing tools 4P for eshops enhanced by services and competitiors. There is also a specially adapted Porter's value chain for eshops and is used a model of e-commerce trust. On this basis it is created the current marketing strategy of eshop including the SWOT analysis and definition of strategic objectives. Identified processes were divided into elementary, key and support groups and relationships between them were made. For the optimization process is used Hammer and Champy methodology and feasibility and success of the thesis is evaluated according to best practises reengineering projects. Reengineered processes are defined with specification, exploited documents, information system and eshop application modules, illustrated by using EPC model and they are defined metrics and specifically listed areas of improvement.