The traditional quality culture in the pharmaceutical industry is driven by the regulatory process of marketing authorisation and manufacturing authorisation. These components of the South African regulatory control system are exclusively technically-orientated, with no managerial focus. This study identifies several quality management principles which could find general application in the pharmaceutical industry. The research compares the current regulatory control system with the total quality concept, and highlights the positive contribution which the total quality approach is able to make in terms of its field of reference; the strategic business value of quality; quality policy formulation; the quality organisational structure; enhanced operations management; and management's control over quality costs, in particular / Economic & Management Sciences / M.Com. (Business Economics)

The traditional quality culture in the pharmaceutical industry is driven by the regulatory process of marketing authorisation and manufacturing authorisation. These components of the South African regulatory control system are exclusively technically-orientated, with no managerial focus. This study identifies several quality management principles which could find general application in the pharmaceutical industry. The research compares the current regulatory control system with the total quality concept, and highlights the positive contribution which the total quality approach is able to make in terms of its field of reference; the strategic business value of quality; quality policy formulation; the quality organisational structure; enhanced operations management; and management's control over quality costs, in particular / Economic and Management Sciences / M.Com. (Business Economics)

H διατριβή διερευνά προβλήματα αποδοτικής οργάνωσης χωροταξικών δεδομένων, προτείνει συγκεκριμένες δενδρικές δομές για τη διαχείρισή τους και, τέλος, δίνει παραδείγματα χρήσης τους σε ειδικές περιοχές εφαρμογών. Το πρώτο κεφάλαιο ασχολείται με το γεωμετρικό πρόβλημα της εύρεσης των ισo-προσανατολισμένων ορθογωνίων που περικλείουν ένα query αντικείμενο που μπορεί να είναι ένα ισο-προσανατολισμένο ορθογώνιο είτε σημείο ή κάθετο / οριζόντιο ευθύγραμμο τμήμα. Για την επίλυσή του προτείνεται μια πολυεπίπεδη δενδρική δομή που βελτιώνει τις πολυπλοκότητες των προηγούμενων καλύτερων λύσεων. Το δεύτερο κεφάλαιο εξετάζει το πρόβλημα της ανάκτησης σημείων σε πολύγωνα. H προτεινόμενη γεωμετρική δομή είναι επίσης πολυεπίπεδη και αποδοτική όταν το query πολύγωνο έχει συγκεκριμένες ιδιότητες. Το τρίτο κεφάλαιο ασχολείται με την εφαρμογή δενδρικών δομών σε δύο βιομηχανικά προβλήματα. Το πρώτο αφορά στη μείωση της πολυπλοκότητας ανίχνευσης συγκρούσεων κατά την κίνηση ενός ρομποτικού βραχίονα σε μια επίπεδη σκηνή με εμπόδια. Ο αλγόριθμος επίλυσης κάνει χρήση μιας ουράς προτεραιότητας και μιας UNION-FIND δομής ενώ αξιοποιεί γνωστές δομές και αλγόριθμους της Υπολογιστικής Γεωμετρίας όπως υπολογισμός κυρτών καλυμμάτων, έλεγχος polygon inclusion, κλπ. Το δεύτερο πρόβλημα ασχολείται με το σχεδιασμό απαιτήσεων υλικών (MRP) σε ένα βιομηχανικό σύστημα παραγωγής. Για το σκοπό αυτό αναπτύχθηκε ένας MRP επεξεργαστής που χρησιμοποιεί διασυνδεμένες λίστες και εκτελείται στην κύρια μνήμη για να είναι αποδοτικός. Το τελευταίο κεφάλαιο εξετάζει το πρόβλημα του ελέγχου της παραγωγής και συγκεκριμένα της δρομολόγησης εργασιών. Στο πλαίσιο αυτό σχεδιάστηκε και υλοποιήθηκε ένα ευφυές σύστημα δρομολόγησης σε περιβάλλον ροής που συνδυάζει γνωσιακή τεχνολογία και προσομοίωση με on-line έλεγχο προκειμένου να υποστηρίξει το διευθυντή παραγωγής στη λήψη αποφάσεων. / Τhe dissertation examines problems of efficient organization of spatial data, proposes specific tree structures for their management, and finally, gives examples of their use in specific application areas. The first chapter is about the problem of finding the iso-oriented rectangles that enclose a query object which can be an iso-oriented rectangle either a point or a vertical / horizontal line segment. A multilevel tree structure is proposed to solve the problem which improves the complexities of the best previous known solutions. The second chapter examines the problem of point retrieval on polygons. The proposed geometric structure is also multileveled and efficient when the query polygon has specific properties. The third chapter is about the application of tree structures in two manufacturing problems. The first one concerns the reduction in the complexity of collision detection as a robotic arm moves on a planar scene with obstacles. For the solution a priority queue and a UNION-FIND structure are used, whereas known data structures and algorithms of Computational Geometry such as construction of convex hulls, polygon inclusion testing, etc. are applied. The second problem is about material requirements planning (MRP) in a manufacturing production system. To this end an MRP processor was developed, which uses linked lists and runs in main memory to retain efficiency. The last chapter examines the production control problem, and more specifically the job scheduling problem. In this context, an intelligent scheduling system was designed and developed for flow shop production control which combines knowledge-based technology and simulation with on-line control in order to support the production manager in decision making.

Indiana University-Purdue University Indianapolis (IUPUI) / Conventional interpretations of WWII hold that the war brought the United States out of the Great Depression and laid the path for future economic prosperity. However, this was not the case for all businesses and industries. During WWII, unprecedented production output was required of U.S. industries to supply the great “Arsenal of Democracy.” Industrial mobilization required the creation of new agencies and commissions to manage the nation’s resources. These organizations created policies that deeply impacted U.S. industries involved in war production. Policies governing such areas as the allocation of raw materials, transportation of finished goods, and distribution of war contracts created challenges for businesses that often resulted in lost productivity and in some cases, loss of profitability. Government regulation of the labor force and labor problems such as labor shortages, high absenteeism and turnover rates, and labor disputes presented further challenges for businesses navigating the wartime economy. Most studies of WWII industrial mobilization have focused on large corporations in high priority industries, such as the aircraft, petroleum, or steel industries, which achieved great success during the war. This thesis presents a case study of The Real Silk Hosiery Mills of Indianapolis, Indiana, a company that is representative of small and mid-sized companies that produced lower priority goods. The study demonstrates that the policies created by the military and civilian wartime agencies favored large corporations and had a negative affect on some businesses like Real Silk. As such,the economic boost associated with the war did not occur across the board.