Global ETD Search

211	X-ray structures of p22 c2 repressor-dna complexes: the mechansism of direct and indirect readout Watkins, Jason Derrick 26 August 2008 (has links) The P22 c2 repressor protein (P22R) binds to DNA sequence-specifically and helps direct the temperate lambdoid bacteriophage P22 to the lysogenic developmental pathway. To gain insight into its DNA binding mechanism, we solved the 1.6 Å x-ray structure of the N-terminal domain (NTD) of P22R in a complex with a DNA fragment containing the synthetic operator sequence [d(ATTTAAGATATCTTAAAT)]2 This operator has an A-T at position 9L and T-A at position 9R and is termed DNA9T. Van der Waals interactions between protein and DNA appear to confer sequence-specificity. The structure of the P22R NTD – NA9T complex suggests that sequence-specificity arises substantially from interaction of a valine with a complementary binding cleft on the major groove surface of DNA9T. The cleft is formed by four methyl groups on sequential base pairs of 5' TTAA 3'. The valine cleft is intrinsic to the DNA sequence and does not arise from protein-induced DNA conformational change. Protein-DNA hydrogen bonding plays a secondary role in specificity. P22 repressor Direct readout Indirect readout Protein binding DNA-protein interactions Van der Waals forces
212	Functional characterisation of Polycomblike and a novel, chromosomal protein interactor from Drosophila melanogaster / by Stanley Robert. Robert, Stanley January 1997 (has links) Bibliography: p. 96-108. / 108, [31] p., [9] leaves of plates : ill. (chiefly col.) ; 30 cm. / Title page, contents and abstract only. The complete thesis in print form is available from the University Library. / The major aim of this thesis is the identification and characterisation of Polycomblike (PCL) protein interactors. The study analyses the ability of PCL to bind directly to DNA anchoring the Pc-G complex to the genes which they repress. / Thesis (Ph.D.)--University of Adelaide, Dept. of Genetics, 1997 Genetic recombination. Protein binding. DNA-protein interactions.
213	Scintillation proximity assay (SPA) measuring p53 DNA binding and total p53 level in human thyroid cancer cell line ARO Xie, Tian. January 2007 (has links) Thesis (M.S.)--State University of New York at Binghamton, Department of Biological Sciences, 2007. / Includes bibliographical references.
214	The proteoglycan perlecan regulates long bone growth through interactions with developmental proteins in the growth plate Smith, Simone Marsha-Lee. January 2007 (has links) Dissertation (Ph.D.)--University of South Florida, 2007. / Title from PDF of title page. Document formatted into pages; contains 168 pages. Includes vita. Includes bibliographical references.
215	Antiphagocytosis by Yersinia pseudotuberculosis : role of the YopH target proteins / Yuan, Ming, January 2006 (has links) Diss. (sammanfattning) Umeå : Umeå universitet, 2007. / Härtill 4 uppsatser.
216	Studies on vitamin A signaling in psoriasis : a comparison between normal and lesional keratinocytes / Karlsson, Teresa, January 2002 (has links) Diss. (sammanfattning) Uppsala : Univ., 2002. / Härtill 4 uppsatser.
217	Mechanisms of regulation of dioxin receptor function / Lindebro, Maria, January 2002 (has links) Diss. (sammanfattning) Stockholm : Karol. inst., 2002. / Härtill 3 uppsatser.
218	Biocomputational studies on protein structures / Nordling, Erik, January 2002 (has links) Diss. (sammanfattning) Stockholm : Karol. inst., 2002. / Härtill 7 uppsatser.
219	Decoding NK cell receptor specificity : functional and structural studies of MHC class 1 subcomponents / Michaëlsson, Jakob, January 2002 (has links) Diss. (sammanfattning) Stockholm : Karolinska institutet, 2002. / Härtill 4 uppsatser.
220	The role of angiomotin in angiogenesis / Levchenko, Tetyana, January 2003 (has links) Diss. (sammanfattning) Stockholm : Karol inst., 2003. / Härtill 4 uppsatser.

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