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2-Methacryloyloxyethyl Phosphorylcholine is an interesting biocompatible monomer. An improved method for the synthesis of poly(MPC) and its copolymers using Reversible Addition-Fragmentation chain Transfer (RAFT) has been discussed in the first part of the thesis. Previous reports related to the synthesis of MPC homopolymers and copolymers in aqueous medium are found to be less effective because of the hydrolysis of chain transfer agent in water. Hydrolysis of chain transfer agent results in the loss of active chain ends thereby, reducing control over polymerization and increasing the polydispersity of resulting polymers. Therefore, in this work MPC polymers were synthesized by RAFT using methanol as solvent. This method of synthesis produced polymers having controlled molecular weights as well as narrow polydispersities. In the second part of the work, methoxydiethylene glycol methacrylate (MeODEGM)-MPC based thermo-responsive core-shell nanogels were synthesized for use in protein encapsulation and release. The size of the nanogels was controlled by varying the concentration of cross-linker. The nanogels were synthesized using an acid degradable crosslinker which helped in the release of encapsulated protein at acidic pH. The effect of various parameters on encapsulation efficiency of proteins was studied and it was found that apart from the size of protein, the cross-linker concentration of nanogel also affected the amount of protein encapsulated. / Chemical Engineering

京都大学 / 0048 / 新制・課程博士 / 博士(薬科学) / 甲第18918号 / 薬科博第32号 / 新制||薬||4(附属図書館) / 31869 / 京都大学大学院薬学研究科薬科学専攻 / (主査)教授 松﨑 勝巳, 教授 加藤 博章, 教授 石濱 泰 / 学位規則第4条第1項該当 / Doctor of Pharmaceutical Sciences / Kyoto University / DGAM