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Novel regulation and functions of AMPK in developing and adult neuronsHamilton, Stevie January 2024 (has links)
The AMP-activated protein kinase (AMPK) is a master metabolic regulator and energy sensor that has been extensively studied in the context of cancer and metabolic disorders. However, its role in neuronal function and morphology remains largely unexplored. This dissertation aims to bridge this gap by investigating the roles of AMPK in maintaining axon homeostasis and regulating mitochondrial morphology in neurons. By identifying novel regulators of AMPK across different cellular compartments, this thesis sheds light on the multifaceted functions of AMPK in shaping neuronal and mitochondrial architecture.
The dissertation is organized into five chapters. Chapter 1 provides a brief background on AMPK, its activation mechanisms, and the downstream pathways it regulates. Chapter 2 introduces with-no-lysine kinase (WNK), a novel axon morphogenic kinase with dual roles in terminal axon branch development and maintenance in mature axons. Chapter 3 investigates the role of AMPK in mediating the loss-of-WNK axonal phenotypes, revealing a critical link between AMPK and axonal integrity. Chapter 4 shifts focus to the mitochondrial, characterizing mitochondrial fission regulator 1-like (MTFR1L) as a novel AMPK-activated protein that regulates mitochondrial morphology.
Finally, Chapter 5 explores the role of AMPK in mediating activity-dependent mitochondrial morphology in hippocampal CA1 neurons, highlighting the dynamic interplay between neuronal activity and mitochondrial dynamics. Collectively, these findings provide novel insights into the multifaceted roles of AMPK in neuronal development, degeneration, and organelle regulation, underscoring the importance of this master kinase in maintaining neuronal health and homeostasis.
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The characterization of a homologue of the regulatory subunit of cyclic amp dependent protein kinase a in Giardia lambliaGibson, Candace S. 01 April 2002 (has links)
No description available.
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Screening of factors that affect GSK-3[beta] expression and study of tau phosphorylation by GSK-3[beta] in cultured cell lines. / CUHK electronic theses & dissertations collectionJanuary 2001 (has links)
by Lee Wing-cheung. / "November 2001." / Thesis (Ph.D.)--Chinese University of Hong Kong, 2001. / Includes bibliographical references (p. 152-169). / Electronic reproduction. Hong Kong : Chinese University of Hong Kong, [2012] System requirements: Adobe Acrobat Reader. Available via World Wide Web. / Mode of access: World Wide Web. / Abstracts in English and Chinese.
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AMP-activated protein kinase : the connection between exercise and type II diabetes /Barnes, Brian R., January 2004 (has links)
Diss. (sammanfattning) Stockholm : Karol. inst., 2004. / Härtill 5 uppsatser.
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Fibroblast growth factor-19 a novel factor that inhibits hepatic fatty acid synthesis /Bhatnagar, Sushant. January 2008 (has links)
Thesis (Ph. D.)--West Virginia University, 2008. / Title from document title page. Document formatted into pages; contains ix, 86 p. : ill. (some col.). Includes abstract. Includes bibliographical references.
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JNK activation and shear stress implications for adaptive and maladaptive signaling /Hahn, Cornelia Su-Heng. January 2008 (has links)
Thesis (Ph. D.)--University of Virginia, 2008. / Title from title page. Includes bibliographical references. Also available online through Digital Dissertations.
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Molecular regulation of power output in single rat skinned cardiac myocytesHerron, Todd J. January 2002 (has links)
Thesis (Ph. D.)--University of Missouri--Columbia, 2002. / Typescript. Vita. Includes bibliographical references (leaves 103-110). Also available on the Internet.
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The effects of omega-3 polyunsaturated fatty acids on AMPK activation and lipid metabolism in skeletal muscleWoodworth-Hobbs, Myra Ellen. January 1900 (has links)
Thesis (M.S.)--West Virginia University, 2009. / Title from document title page. Document formatted into pages; contains iv, 60 p. : ill. (some col.). Includes abstract. Includes bibliographical references.
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Roles of cellular FLICE-inhibitory protein (c-FLIP) and Pl3K/Akt in Fas (CD95)-induced NF-[kappa]B activation and apoptosis through death effector domainsLu, Bin, January 2005 (has links)
Thesis (Ph. D.)--West Virginia University, 2005. / Title from document title page. Document formatted into pages; contains viii, 95 p. : ill. (some col.). Includes abstract. Includes bibliographical references (p. 82-95).
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Pl3-kinase mediates cSrc activation and podosome formation through the adaptor protein, AFAP-110, in response to PKC[alpha] activationWalker, Valerie Glynis. January 2007 (has links)
Thesis (Ph. D.)--West Virginia University, 2007. / Title from document title page. Document formatted into pages; contains viii, 306 p. : ill. (some col.). Vita. Includes abstract. Includes bibliographical references.
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