Global ETD Search

11	Neuropeptide Y receptor subtypes involved in the stimulation of ventricular cell hypertrophy and associated upregulation of gene expression Nicholl, Suzanne Maureen January 2000 (has links) No description available. 572 Protein synthesis; Peptides
12	The regulation of protein synthesis in adult rat cardiomyocytes Huang, Brandon Pei Han 11 1900 (has links) Protein synthesis (mRNA) is tightly regulated under numerous conditions in cardiomyocytes. It can be activated by hormones such as insulin and also by other agents such as phenylephrine (PE) that activates hypertrophy in the heart. Cardiac hypertrophy involves an increase in the muscle mass of the heart, principally in the left ventricular muscle, and the increase is due to enlarged cell size, not increased cell number. A pivotal element of cardiac hypertrophy is an elevation in the rates of protein synthesis, which drives the increase in cell size causing hypertrophy. Unfortunately, we currently lack the understanding of the basic mechanisms that drives hyperactivated protein synthesis. Cardiac hypertrophy is clinically important because it is a major risk factor for heart failure. It initially serves as an adaptive response to increase cardiac output in response to higher demand, but ultimately leads to deterioration of contractility of the heart if hypertrophy is sustained. The main goal of this research project is to understand how hypertrophic agents, such as phenylephrine (PE), activate protein synthesis using adult rat ventricular cardiomyocytes as a model. Specifically, this study focuses on how the translational initiation is controlled by upstream signalling pathways. Protein synthesis Cardiac hypertrophy
13	The role of individual domains of eIF4G in translation initiation Wood, Wendy January 2000 (has links) No description available. 572 Protein synthesis
14	Synthesis and release of prostaglandins in the central nervous system : Studies on possible changes brought about during fever; role of protein synthesis in the pathology of fever Sawhney, V. K. January 1983 (has links) No description available. 572 Protein synthesis in fever
15	Studies on translation initiation factors in Schizosaccharomyces pombe Curtis, Penelope Susan January 1999 (has links) No description available. 572 Protein synthesis; Yeast
16	Accumulation of protein in the cell cycle of Chlorella McGookin, R. January 1980 (has links) No description available. 572 Protein synthesis in algae
17	The regulation of protein synthesis in adult rat cardiomyocytes Huang, Brandon Pei Han 11 1900 (has links) Protein synthesis (mRNA) is tightly regulated under numerous conditions in cardiomyocytes. It can be activated by hormones such as insulin and also by other agents such as phenylephrine (PE) that activates hypertrophy in the heart. Cardiac hypertrophy involves an increase in the muscle mass of the heart, principally in the left ventricular muscle, and the increase is due to enlarged cell size, not increased cell number. A pivotal element of cardiac hypertrophy is an elevation in the rates of protein synthesis, which drives the increase in cell size causing hypertrophy. Unfortunately, we currently lack the understanding of the basic mechanisms that drives hyperactivated protein synthesis. Cardiac hypertrophy is clinically important because it is a major risk factor for heart failure. It initially serves as an adaptive response to increase cardiac output in response to higher demand, but ultimately leads to deterioration of contractility of the heart if hypertrophy is sustained. The main goal of this research project is to understand how hypertrophic agents, such as phenylephrine (PE), activate protein synthesis using adult rat ventricular cardiomyocytes as a model. Specifically, this study focuses on how the translational initiation is controlled by upstream signalling pathways. Protein synthesis Cardiac hypertrophy
18	The regulation of protein synthesis in adult rat cardiomyocytes Huang, Brandon Pei Han 11 1900 (has links) Protein synthesis (mRNA) is tightly regulated under numerous conditions in cardiomyocytes. It can be activated by hormones such as insulin and also by other agents such as phenylephrine (PE) that activates hypertrophy in the heart. Cardiac hypertrophy involves an increase in the muscle mass of the heart, principally in the left ventricular muscle, and the increase is due to enlarged cell size, not increased cell number. A pivotal element of cardiac hypertrophy is an elevation in the rates of protein synthesis, which drives the increase in cell size causing hypertrophy. Unfortunately, we currently lack the understanding of the basic mechanisms that drives hyperactivated protein synthesis. Cardiac hypertrophy is clinically important because it is a major risk factor for heart failure. It initially serves as an adaptive response to increase cardiac output in response to higher demand, but ultimately leads to deterioration of contractility of the heart if hypertrophy is sustained. The main goal of this research project is to understand how hypertrophic agents, such as phenylephrine (PE), activate protein synthesis using adult rat ventricular cardiomyocytes as a model. Specifically, this study focuses on how the translational initiation is controlled by upstream signalling pathways. / Medicine, Faculty of / Biochemistry and Molecular Biology, Department of / Graduate Protein synthesis Cardiac hypertrophy
19	Cynlins in Xenopus laevis Minshull, Jeremy Stephen January 1988 (has links) No description available. 572 Protein synthesis and the cell cycle
20	The role of the eIF4F complex in translation regulation Rau, Michael January 1996 (has links) No description available. 572 Protein synthesis; Initiation; eIF4E

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