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Alteration of fibroblast cell shape and induction of procollagenase synthesis by calcium channel blockers, calmodulin inhibitors and protein kinase C inhibitors /Doong, Joe-Yuan Howard. January 1996 (has links)
Thesis (Ph. D.)--University of Chicago, Dept. of Organismal Biology and Anatomy, March 1997. / Includes bibliographical references. Also available on the Internet.
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Immunohistochemical analysis of Paks expression in ovarian cancer /Woo, Wing-shuen, Nina. January 2006 (has links)
Thesis (M. Med. Sc.)--University of Hong Kong, 2006.
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Pim kinases phosphorylate p21 CiP1/WAF1 and c-MycZhang, Yandong, January 2007 (has links) (PDF)
Thesis (Ph. D.)--Washington State University, August 2007. / Includes bibliographical references.
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A Proposed Molecular Mechanism for the Activation of a Calcium/Phospholipid-Dependent Protein Kinase in P1798 LymphosarcomaElson, James L. 05 1900 (has links)
Calcium/phospholipid-dependent protein kinase (PKC) was purified from P1798 lymphosarcoma. It was demonstrated that uncomplexed calcium and uncomplexed phosphatidylserine are the activators, that the activation of PKC requires that calcium bind first, that the activation of PKC requires that calcium bind first, that high calcium concentrations inhibit PKC activation, and that calcium inhibition can be overcome by phosphatidylserine.
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Phosphorylation of Nonmuscle Myosin by Calcium-Dependent and Independent Protein KinasesHassell, Tommy C. (Tommy Clarence) 12 1900 (has links)
Nonmuscle myosin from bovine thymus was purified, characterized , and phosphorylated with MLCK, H4PK, and Protein Kinase C. Phosphorylation occured exclusively on the myosin regulatory light chain. Phosphorylation by MLCK and H4PK resulted in the activation of the MgATPase activity as well as filament assembly of nonmuscle myosin.
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Evidence for a Role of the Multifunctional Calcium/Calmodulin-Dependent Protein Kinase II in Insulin SecretionWenham, Robert M. (Robert Michael) 12 1900 (has links)
Calcium/calmodulin-dependent protein kinase II (CaM kinase II) is demonstrated to exist in the ß-cell and immunopecipitation. Glucose and potassium significantly stimulate the rapid autophosphorylation of CaM kinase II and proportionally induce autonomous activity of the kinase in a dose-dependent manner that parallels insulin secretion. The activation of CaM kinase II, alloxan, KN-62 and KN-93, suggest that the enzyme is an integral component of insulin secretion and/or related processes in the β-cell.
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The Association of Cell Cycle and Growth Related Protein Kinases with the Fibroblast CytoskeletonAtway, Nader G. January 1999 (has links)
No description available.
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Regulation of an S6/H4 Kinase in Crude Lymphosarcoma P1798 PreparationsTaylor, Allison Antoinette 12 1900 (has links)
Purified S6/H4 kinase (Mr 60,000) requires autophosphorylation for activation. A rabbit anti-S6/H4 kinase peptide (SVIDPVPAPVGDSHVDGAAK) antibody recognized both the S6/H4 kinase holoenzyme and catalytic domain. Immunoreactivity with p60 kinase protein, and S6/H4 kinase activity were precisely correlated in fractions obtained from ion exchange chromatography of P1798 lymphosarcoma extracts. An enzyme which catalyzed the MgATP-dependent phosphorylation and activation of S6/H4 kinase coeluted with immunoreactivity from Mono 5, but not Mono Q chromatography. Since S6/H4 kinase is homologous with rac-activated PAK65, the observation that phosphorylation is also required for activation suggests a complex mechanism for in vivo activation of the S6/H4 kinase.
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A novel A kinase anchoring protein targets PKA to voltage-gated calcium channels /Gray, Peter C. January 1998 (has links)
Thesis (Ph. D.)--University of Washington, 1998. / Vita. Includes bibliographical references (leaves [76]-87).
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Neural specific isoforms of protein kinase A and the role of protein kinases in neural gene expression /Guthrie, Chris Raymond. January 1996 (has links)
Thesis (Ph. D.)--University of Washington, 1996. / Vita. Includes bibliographical references (leaves [68]-80).
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