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Plasma membrane arabinogalactan proteinsSnogerup, Lars. January 1900 (has links)
Thesis (doctoral)--Lund University, 1997.
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Plasma membrane arabinogalactan proteinsSnogerup, Lars. January 1900 (has links)
Thesis (doctoral)--Lund University, 1997.
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Pharmacodynamic and pharmacokinetic studies of polysaccharide peptide (PSP), an extract from fungus coriolus versicolor. / CUHK electronic theses & dissertations collectionJanuary 2003 (has links)
Chan Siu Lung. / "June 2003." / Thesis (Ph.D.)--Chinese University of Hong Kong, 2003. / Includes bibliographical references (p. 220-247). / Electronic reproduction. Hong Kong : Chinese University of Hong Kong, [2012] System requirements: Adobe Acrobat Reader. Available via World Wide Web. / Mode of access: World Wide Web. / Abstracts in English and Chinese,
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The role of small leucine-rich proteoglycans in non-scarring human oral mucosal wound healingHonardoust, Dariush 11 1900 (has links)
Small leucine-rich proteoglycans (SLRPs) decorin, biglycan, fibromodulin and lumican are
extracellular matrix (ECM) molecules that regulate collagen fibrilogenesis, cell functions and
activity of transforming growth factor-P (TGF-ß). Thus, SLRPs may play critical roles in wound
healing. In contrast to dermal wounds, gingival wounds regenerate with minimal scaring.
However, the cellular and molecular mechanisms involved in this processes are not known. The
aim of this study was to analyze the abundance of SLRPs, TGF-ß and Endo180, the major
collagen endocytosis receptor in fibroblasts, in normal unwounded gingiva and during wound
healing. The association of Endo180 with decorin was also investigated during wound healing.
We hypothesized that compared to normal unwounded tissue, gingiva shows distinct localization
and altered accumulation of SLRPs, TGF-ß and Endo180 during wound healing. To further
analyze functions of SLRPs, we studied interaction of decorin with cultured gingival fibroblasts.
Double immunostaining was used to study the localization of SLRPs, Endo180 or TGF-ß
in tissue sections from normal human gingiva and up to 60 days after experimental wounding.
The expression of Endo180 in cultured fibroblasts and keratinocytes was studied by
immunoblotting and reverse transcriptase-polymerase chain reaction. To study interaction of
cultured fibroblasts with decorin and decorin-induced signaling we used immunoblotting,
function-blocking antibodies, pharmacological inhibitors, quantitative immunocytochemistry and
RNA interference.
In normal gingiva and during wound healing, SLRPs localized to collagen in a sitespecific
manner. The immunoreactivity of SLRPs, TGF-ß1, TGF-ß3 and Endo180 was spatially
and temporally regulated in myofibroblasts, pericytes, macrophages, endothelial and epithelial
cells during wound healing. During wound healing, decorin colocalized with Endo180 in
myofibroblasts. In cultured fibroblasts, decorin induced phosphorylation of distinct receptor
tyrosine kinases leading to formation of reactive oxygen species (ROS) via the PI3K/mTOR
signaling pathway. This was necessary for decorin endocytosis mainly via the clathrin-pathway.
SLRPs may play a role in gingival wound re-epithelialization, collagen fibrilogenesis,
ECM remodeling and cell signaling. Specifically, increased abundance of fibromodulin, decorin
and TTGF-ß3 relative toTGF-ß1 may contribute to the reduced scaring during gingival wound
healing. Decorin may interact with Endo180 to modulate its function and regulates cell signaling
by inducing ROS formation.
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Cell-surface proteoglycan expression by periodontal cells /Worapamorn, Wilairat. January 2001 (has links) (PDF)
Thesis (Ph. D.)--University of Queensland, 2001. / Includes bibliographical references.
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Immunomodulatory properties of the Chinese medicinal extract polysaccharide peptideWong, Ka-wai, Creany, 黃嘉慧 January 2003 (has links)
published_or_final_version / abstract / toc / Zoology / Master / Master of Philosophy
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The role of small leucine-rich proteoglycans in non-scarring human oral mucosal wound healingHonardoust, Dariush 11 1900 (has links)
Small leucine-rich proteoglycans (SLRPs) decorin, biglycan, fibromodulin and lumican are
extracellular matrix (ECM) molecules that regulate collagen fibrilogenesis, cell functions and
activity of transforming growth factor-P (TGF-ß). Thus, SLRPs may play critical roles in wound
healing. In contrast to dermal wounds, gingival wounds regenerate with minimal scaring.
However, the cellular and molecular mechanisms involved in this processes are not known. The
aim of this study was to analyze the abundance of SLRPs, TGF-ß and Endo180, the major
collagen endocytosis receptor in fibroblasts, in normal unwounded gingiva and during wound
healing. The association of Endo180 with decorin was also investigated during wound healing.
We hypothesized that compared to normal unwounded tissue, gingiva shows distinct localization
and altered accumulation of SLRPs, TGF-ß and Endo180 during wound healing. To further
analyze functions of SLRPs, we studied interaction of decorin with cultured gingival fibroblasts.
Double immunostaining was used to study the localization of SLRPs, Endo180 or TGF-ß
in tissue sections from normal human gingiva and up to 60 days after experimental wounding.
The expression of Endo180 in cultured fibroblasts and keratinocytes was studied by
immunoblotting and reverse transcriptase-polymerase chain reaction. To study interaction of
cultured fibroblasts with decorin and decorin-induced signaling we used immunoblotting,
function-blocking antibodies, pharmacological inhibitors, quantitative immunocytochemistry and
RNA interference.
In normal gingiva and during wound healing, SLRPs localized to collagen in a sitespecific
manner. The immunoreactivity of SLRPs, TGF-ß1, TGF-ß3 and Endo180 was spatially
and temporally regulated in myofibroblasts, pericytes, macrophages, endothelial and epithelial
cells during wound healing. During wound healing, decorin colocalized with Endo180 in
myofibroblasts. In cultured fibroblasts, decorin induced phosphorylation of distinct receptor
tyrosine kinases leading to formation of reactive oxygen species (ROS) via the PI3K/mTOR
signaling pathway. This was necessary for decorin endocytosis mainly via the clathrin-pathway.
SLRPs may play a role in gingival wound re-epithelialization, collagen fibrilogenesis,
ECM remodeling and cell signaling. Specifically, increased abundance of fibromodulin, decorin
and TTGF-ß3 relative toTGF-ß1 may contribute to the reduced scaring during gingival wound
healing. Decorin may interact with Endo180 to modulate its function and regulates cell signaling
by inducing ROS formation.
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Versican : regulation, purification, and biological properties of a candidate prognostic indicator for breast cancer /Supaporn Suwiwat. January 2003 (has links) (PDF)
Thesis (Ph.D.)--University of Adelaide, Dept. of Medicine and The Hanson Institute, 2004. / "December 2003" Includes bibliographical references (leaves 106-128).
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The role of small leucine-rich proteoglycans in non-scarring human oral mucosal wound healingHonardoust, Dariush 11 1900 (has links)
Small leucine-rich proteoglycans (SLRPs) decorin, biglycan, fibromodulin and lumican are
extracellular matrix (ECM) molecules that regulate collagen fibrilogenesis, cell functions and
activity of transforming growth factor-P (TGF-ß). Thus, SLRPs may play critical roles in wound
healing. In contrast to dermal wounds, gingival wounds regenerate with minimal scaring.
However, the cellular and molecular mechanisms involved in this processes are not known. The
aim of this study was to analyze the abundance of SLRPs, TGF-ß and Endo180, the major
collagen endocytosis receptor in fibroblasts, in normal unwounded gingiva and during wound
healing. The association of Endo180 with decorin was also investigated during wound healing.
We hypothesized that compared to normal unwounded tissue, gingiva shows distinct localization
and altered accumulation of SLRPs, TGF-ß and Endo180 during wound healing. To further
analyze functions of SLRPs, we studied interaction of decorin with cultured gingival fibroblasts.
Double immunostaining was used to study the localization of SLRPs, Endo180 or TGF-ß
in tissue sections from normal human gingiva and up to 60 days after experimental wounding.
The expression of Endo180 in cultured fibroblasts and keratinocytes was studied by
immunoblotting and reverse transcriptase-polymerase chain reaction. To study interaction of
cultured fibroblasts with decorin and decorin-induced signaling we used immunoblotting,
function-blocking antibodies, pharmacological inhibitors, quantitative immunocytochemistry and
RNA interference.
In normal gingiva and during wound healing, SLRPs localized to collagen in a sitespecific
manner. The immunoreactivity of SLRPs, TGF-ß1, TGF-ß3 and Endo180 was spatially
and temporally regulated in myofibroblasts, pericytes, macrophages, endothelial and epithelial
cells during wound healing. During wound healing, decorin colocalized with Endo180 in
myofibroblasts. In cultured fibroblasts, decorin induced phosphorylation of distinct receptor
tyrosine kinases leading to formation of reactive oxygen species (ROS) via the PI3K/mTOR
signaling pathway. This was necessary for decorin endocytosis mainly via the clathrin-pathway.
SLRPs may play a role in gingival wound re-epithelialization, collagen fibrilogenesis,
ECM remodeling and cell signaling. Specifically, increased abundance of fibromodulin, decorin
and TTGF-ß3 relative toTGF-ß1 may contribute to the reduced scaring during gingival wound
healing. Decorin may interact with Endo180 to modulate its function and regulates cell signaling
by inducing ROS formation. / Dentistry, Faculty of / Graduate
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Aggregation of proteoglycans in growth and articular cartilages a thesis submitted in partial fulfillment ... in orthodontics ... /Bollen, Anne-Marie. January 1986 (has links)
Thesis (M.S.)--University of Michigan, 1986.
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