Spelling suggestions: "subject:"pseudomonas aeruginosa"" "subject:"seudomonas aeruginosa""
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Caractérisation des souches de Pseudomonas aeruginosa isolées des patients atteints de la fibrose kystique par différentes méthodes de typageHafiane, Anouar January 2007 (has links)
Mémoire numérisé par la Division de la gestion de documents et des archives de l'Université de Montréal
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Disruption of Pseudomonas aeruginosa quorum sensing using high-sensitivity phage antibodies derived from immunised sheepPalliyil, Soumya January 2010 (has links)
Pseudomonas aeruginosa is an opportunistic human pathogen which, like many other Gram negative pathogens, employs quorum sensing - regulated virulence factors to establish an infection in its host. Quorum sensing in P. aeruginosa populations is controlled by low molecular weight (hapten) signalling molecules known as homoserine lactones (HSLs). Blocking bacterial communication using antibodies is an attractive strategy for infection control as QS takes a central role in P. aeruginosa infections, and antibodies can recognise their targets with exquisite specificity. There are two well-studied QS circuits in P. aeruginosa- the Las system and the Rhl system, controlled by two autoinducers compounds, 3-oxo-C12-HSL and C4-HSL respectively. Antibodies raised against HSL compounds can reduce the expression of virulence factors controlled by QS circuit and the immunomodulatory effects of 3- oxo-C12-HSL. In order to generate antibodies with high sensitivities against the autoinducer compounds of P. aeruginosa, a panel of HSL compounds was synthesised, conjugated to the carrier protein and used for sheep immunisation. High specificity anti-HSL antibodies were isolated from an immunised sheep antibody repertoire using phage display technology. These phage antibody hits were converted into single chain antibody (scAb) format, which possessed a HuCκ gene for detection and 6x histidine tag for purification. Soluble scAbs expressed in E. coli were purified and characterised using ELISA. Unique clones showing high sensitivity for free HSL compounds were reformatted into sheep-mouse chimeric IgGs, expressed transiently in COS 7 cells and characterised using biochemical assays. These cross-reactive monoclonal antibodies were shown to recognise HSL compounds in low nanomolar concentrations and have the potential to reduce virulence gene expression in P. aeruginosa.
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A mass spectrometric examination of some carbohydrates.Peltier, John M. MacLean, D.B. Unknown Date (has links)
Thesis (Ph.D.)--McMaster University (Canada), 1992. / Source: Dissertation Abstracts International, Volume: 54-08, Section: B, page: 4119. Adviser: D. B. MacLean.
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External otitis and its treatment. Is a group III steroid without antibiotics sufficient therapy? : experimental and clinical studies /Emgård, Per, January 2005 (has links)
Diss. Umeå : Umeå universitet, 2005.
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Mechanisms of adaptive mutations in bacteria /Kugelberg, Elisabeth, January 2005 (has links)
Diss. (sammanfattning) Stockholm : Karol. inst., 2005. / Härtill 4 uppsatser.
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Cellular targets of Pseudomonas aeruginosa toxin Exoenzyme S /Henriksson, Maria, January 2003 (has links)
Diss. (sammanfattning) Umeå : Univ., 2003. / Härtill 5 uppsatser.
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Type III secretion mediated translocation of effector exoenzymes by Pseudomonas aeruginosa /Sundin, Charlotta, January 2003 (has links)
Diss. (sammanfattning) Umeå : Univ., 2003. / Härtill 6 uppsatser.
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Nozokomiyal infeksiyonlarda izole edilen pseudomonas aeruginosa suşlarında antibiyotik sinerjizmi /Demirdal, Tuna. Yaylı, Güler. January 2002 (has links) (PDF)
Tez (Tıpya Uzmanlık) - Süleyman Demirel Üniversitesi, Tıp Fakültesi, Enfeksiyon Hastalıkları ve Klinik Mikrobiyoloji Anabilim Dalı, 2002. / Bibliyografya var.
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Detergent-induced cell aggregation in Pseudomonas aeruginosaKlebensberger, Janosch. January 2007 (has links)
Konstanz, Univ., Diss., 2007.
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Receptor polymorphisms and non-classical immune stimuli in bacterial immune recognitionDehus, Oliver. January 2008 (has links)
Konstanz, Univ., Diss., 2008.
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