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  • About
  • The Global ETD Search service is a free service for researchers to find electronic theses and dissertations. This service is provided by the Networked Digital Library of Theses and Dissertations.
    Our metadata is collected from universities around the world. If you manage a university/consortium/country archive and want to be added, details can be found on the NDLTD website.

Clinical evidence for the treatment of moderate to severe psoriasis

Spuls, Phyllis Ira, January 2002 (has links)
Proefschrift Universiteit van Amsterdam. / Met bibliogr., lit. opg. - Met samenvatting in het Nederlands.

À propos d'un cas de psoriasis pustuleux généralisé, type Zumbusch.

Maquaire, Janine, January 1900 (has links)
Thèse--Méd.--Reims, 1973. N°: N° 19. / Bibliogr. ff. I-XI.

Die Bedeutung des humanen Adhäsionsproteins Thy-1 (CD90) im Rahmen der Therapie der Psoriasis vulgaris

Fischer, Saskia 10 February 2011 (has links) (PDF)
Universität Leipzig, Dissertation 77 Seiten, 78 Literaturangaben, 9 Abbildungen, 5 Tabellen Die Psoriasis vulgaris ist eine chronisch-entzündliche Hautkrankheit, bei der unter anderem neutrophile Granulozyten (PMNC) beteiligt sind. Bei der Einwanderung dieser Zellen spielen Adhäsionsmoleküle wie beispielsweise das humane Thy-1 auf aktivierten Endothelzellen eine wichtige Rolle. Interessanterweise variiert die Stärke der Adhäsion neutrophiler Granulozyten an Thy-1: Bereits nach einer zweitägigen Standardtherapie der Psoriasis ist eine Reduktion der Thy-1-Adhäsion der PMNC feststellbar. Dieser Befund sollte nun an einer größeren Patientengruppe überprüft werden. Zuvor musste geklärt werden, ob es eine einfachere und schnellere Methode zur Bestimmung der Adhäsion neutrophiler Granulozyten an Thy-1 als das bisherige Standardverfahren, einem Adhäsionsassay an Thy-1 - transfizierte CHO – Zellen, gibt. Daher wurde als alternative Methode ein Adhäsionsassay von PMNC an immobilisierten, rekombinantem, humanem Thy-1 (rThy-1) untersucht. Jedoch stellte das Alternativverfahren keine Verbesserung im Vergleich zum Standardverfahren dar. Im Folgenden wurde daher die Standardmethode verwendet, um in einer Phase IV Studie die Thy-1-Adhäsion unter Therapie mit Efalizumab bei 18 Patienten mit einer mittelschweren bis schweren Psoriasis vulgaris vom Plaque-Typ (PASI >12) zu untersuchen. Die Ergebnisse zeigten, dass die Thy-1-Adhäsion von Respondern (Patienten mit Psoriasis, die auf Efalizumab mit einer PASI-Reduktion über 50% nach 12wöchiger Therapie reagieren) bereits vor Beginn der Therapie im Vergleich zu der Thy-1-Adhäsion bei Non-Respondern (PASI-Reduktion unter 50%) erhöht war. Zudem zeigten die neutrophilen Granulozyten von Respondern im Gegensatz zu Non-Respondern bereits in den ersten beiden Wochen nach Beginn der Behandlung eine signifikant abnehmende Adhäsion an Thy-1. Somit könnte die Bestimmung der Adhäsion neutrophiler Granulozyten an Thy-1 möglicherweise sowohl vor Beginn als auch während einer Therapie mit Efalizumab ein prognostischer Marker zur Diskriminierung von Respondern und Non-Respondern sein.

The effect of Maltineem® (Azadirachta indica leaf extract) on psoriasis

Gower, Neil Travis 11 June 2009 (has links)

De behandeling van psoriasis met cytostatica. The treatment of psoriasis with cytostatics.

Smit, Frederik, January 1900 (has links)
Proefschrift--Utrecht. / Vita. Summary in English. Includes bibliography.

Effects of novel immunosuppressive agents on adhesion molecule expression and cell-mediated immune responses

Sainsbury, Tracey January 1994 (has links)
The specific anti-T lymphocyte immunosuppressive drugs cyclosporine A (CsA), FK-506 (FK) and rapamycin (RPM) have revolutionized the field of allograft transplantation and have recently been evaluated for use in autoimmune diseases. Effects of immunosuppressive drugs on adhesion molecule expression in the putative autoimmune conditions psoriasis, through the use of keratinocyte (KC) cell culture techniques, and alopecia areata were investigated. In the Dundee Experiment Bald Rat, a model of alopecia areata, hair regrowth was only apparent with CsA therapy and FK had a high toxicity profile. <I>In vivo</I> the observed cutaneous reduction of ICAM-1 and LFA-1 expression particularly around the hair bulbs was due to the effects of CsA and FK on the inflammatory cell infiltrate, especially since the associated cutaneous lymphocyte populations were reduced with drug. This is corroborated by the results obtained from <I>in vitro</I> culture of human KC, since cytokine-induced expression and release of ICAM-1 by KC was unaffected by CsA, RPM or FK treatment. CsA and RPM, but not FK, however, had an observable cytostatic effect on unstimulated and more especially, cytokine-stimulated KC proliferation and may, therefore, clinically inhibit KC hyperplasia, which is characteristic of psoriasis. This study shows that CsA, FK and RPM may inhibit either directly but more likely in an indirect manner, cellular adhesion molecule expression during immune reactions. This effect will lower the possible number of cellular interactions and furthermore, reduce intracellular co-signalling events necessary for cellular activation which accounts for the overall inhibition of cell-mediated immune responses by these novel immunosuppressive drugs.

Cyclosporin for psoriasis : clinical and immunopathological studies

Powles, A. V. January 1989 (has links)
Ten patients with severe intractable psoriasis were treated with cyclosporin (CyA) at an average dose of 3 mg/kg/day for a period of 12 weeks. At the end of the study, 5 patients had a greater than 90% reduction in their PASI (psoriasis area severity index) score, 3 an 80%, one a 69% and one a 52% reduction. In a long term study, 13 patients with severe psoriasis were treated with CyA for an average duration of 2.5 years. The average dose of CyA was 3 mg/kg/day, with a range of 1 - 5 mg/kg/day. The average reduction in mean PASI score throughout the study was 70 - 80%. Seven of the 13 patients developed a rise in blood pressure, 3 of whom required antihypertensive therapy. Studies on possible nephrotoxicity showed that 4 of the 13 had a greater than 30% rise in their serum creatinine compared to their baseline value. 6 of the 13 patients had a low glomerular filtration rate (GFR) at the end of the study, but this rose in all 6 when CyA was discontinued, and to normal levels in 5 patients. In the sixth, a renal biopsy was performed which showed no structural damage due to CyA. In a further 11 patients, the mean GFR was shown to fall significantly after 9 weeks of CyA. Thus, CyA causes impairment of renal function with a dose of 3 mg/kg/day, but this impairment appears to be reversible when CyA is stopped. Six patients with plaque psoriasis were treated with topical CyA, and a further 10 with intralesional CyA. Topical CyA was ineffective, but intralesional CyA was effective in clearing psoriasis, implying that failure of topical preparations is probably due to lack of penetration. T cell and dendritic cell subsets in psoriasis were studied during oral CyA, and at the end of intralesional CyA treatment. After oral CyA, total CD4 and CD8, and DR+CD8 cells were decreased in the epidermis and dermis. However, DR+CD4 cells were decreased in the dermis but not the epidermis. After intralesional CyA, total and DR+CD4 and CD8 cells were decreased in both dermis and epidermis. The most significant effect of both intralesional and oral CyA on the dendritic cells was the decrease of the DR+CD1-subset.

Psoriasis, its two labels in Chinese and its psychological impacts

Cheung, Tat, Boris., 張達. January 2010 (has links)
published_or_final_version / Psychology / Doctoral / Doctor of Philosophy

Approaches to the synthesis of 1,8-dihydroxy-9-anthrones

Sharghi, H. January 1988 (has links)
No description available.

Improvement of psoralen photochemotherapy : photobiological, pharmacological and clinical studies

Sakuntabhai, Anavaj January 1992 (has links)
No description available.

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