Sonification is the systematic transformation of data to sound. Sonification is a means to communicate information, to support navigation, or to explore data. In a multi-disciplinary research project we develop a psychoacoustically-motivated sonification that supports surgeons’ orientation in image-guided interventions. One drawback of image-guidance is that neither the location of monitors nor the displayed view on the patient’s anatomy coincides with the actual viewpoint of the surgeon. Surgeons need to mentally scale, rotate, and translate the displayed graphics. These operations are cognitively demanding. Sonification can reduce cognitive load and relieve the visual channel to improve the ergonomic situation in the operating room by communicating the location of the target, relative to the tool tip, like the center of a tumor relative to the ablation needle. By means of psychoacoustic sonification we ensure that the sounds are readily interpretable in terms of orthogonal and linear dimensions with a high resolution.