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  • About
  • The Global ETD Search service is a free service for researchers to find electronic theses and dissertations. This service is provided by the Networked Digital Library of Theses and Dissertations.
    Our metadata is collected from universities around the world. If you manage a university/consortium/country archive and want to be added, details can be found on the NDLTD website.
1

Studies on Pyridine n-oxides

Knott, Jane Marie January 1995 (has links)
The work described herein is directed towards the Claisen rearrangements and [3+2] cycloaddition reaction of pyridine N-oxide systems. The pyridine N-oxide molecule is a very versatile and useful synthetic intermediate for the construction of more complex pyridines. Chapter 1 contains a review of work carried out within the group towards Claisen rearrangement of benzene-type systems. The acid catalysed rearrangement of these systems affords a high degree of regioselectivity. A literature survey of the [3+2] cycloaddition reaction of both aliphatic nitrones and aromatic N-oxides with various dipolarophiles is also included. Access to many stereochemically pure products demonstrates that the [3+2] cycloaddition has become a very important ring-forming reaction. Chapter 2 describes development of two Claisen rearrangement precursors and their subsequent attempted Claisen rearrangement is outlined. Chapter 3 details the construction of a range of 3-substituted pyridine N-oxides. Their attempted intermolecular cycloaddition, by thermal means and at high pressure, with mono- and di-activated dipolarophiles is described. Chapter 4 outlines attempts towards and the final synthesis of the ester cycloaddition precursors. Attempted intramolecular [3+2] cycloaddition of these substrates both thermally and under high pressure is summarised. Chapter 5 describes approaches towards [3+2] cycloaddition precursors that contain mono- and di-activated dienophiles. The synthesis of a variety of 3-substituted pyridines is detailed.
2

Synthesis and gelation studies of Bis(Amino acid)-containing pyridine-2,6-dicarboxamide derivatives. / CUHK electronic theses & dissertations collection

January 2004 (has links)
by Wang Guo-Xin. / "April 2004." / Thesis (Ph.D.)--Chinese University of Hong Kong, 2004. / Includes bibliographical references (p. 184-194). / Electronic reproduction. Hong Kong : Chinese University of Hong Kong, [2012] System requirements: Adobe Acrobat Reader. Available via World Wide Web. / Mode of access: World Wide Web. / Abstracts in English and Chinese.

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