In order to improve the performance of simulation and the convenience of use with OSCI TLM-2.0 Standard on QEMU and SystemC based virtual platform we proposed previously called QSC, this thesis presents a novel approach for integrating OSCI TLM-2.0 with QSC. By moving the OSCI TLM-2.0 interconnect bus outside of the Bus Function Model (BFM), the proposed approach can not only accelerate the simulation speed but also make it easy to add OSCI TLM-2.0 based Intellectual Properties (IPs) to the QSC. Experimental results show that the proposed approach can speed up all the simulations by a factor from 2.8 up to 3.255 on average when compared with the previous approach.