Orientador: Rosana Rossi Ferreira / Banca: Margarida Juri Saeki / Banca: Eliana Maria Ravasi Stéfano Semionato / Resumo:O aprimoramento de uma formulação envolve várias etapas importantes que englobam desde o conhecimento das características dos insumos utilizados, até a comprovação que a aplicação é segura para posterior comercialização. O objetivo deste trabalho é o de estudar a utilização da quitosana, plasma fresco congelado (PFC) e concentrado de plaquetas (CP) no reparo de tecidos epiteliais principalmente por feridas crônicas de etiologia venosa. Para tal serão produzidas membranas transdérmicas de quitosana associadas ao PFC e CP com a utilização de um agente reticulante adsorvido em diferentes concentrações. Estima-se que quase 3% da população brasileira é portadora desse tipo de lesão, que se eleva para 10% no caso dos diabéticos, e que em torno de 4 milhões de pessoas sejam portadoras de lesões crônicas ou tenham algum tipo de complicação no processo de cicatrização. Busca-se, portanto, novos recursos e tecnologias que possibilitem o acesso da população a um tratamento eficiente, eficaz e de baixo custo / Abstract:The improvement of a formulation involves several important steps that range from knowledge of the characteristics of the inputs used, until proof that the application is safe for commercialization. The objective of this work is to study the use of chitosan and platelet concentrates CP in the repair of epithelial tissues mainly by chronic venous wounds. This will be produced transdermal membranes chitosan CP associated with the use of cross linking agents adsorbed at various concentrations. It is estimated that nearly 3% of the population suffer from this type of injury, which rises to 10% for diabetics, and that around 4 million people are suffering from chronic injuries or have some type of complication in the process healing. Search, therefore, new features and technologies that enable the population access to a treatment effective, efficient and low cost / Mestre

Made available in DSpace on 2014-06-11T19:23:07Z (GMT). No. of bitstreams: 0 Previous issue date: 2012-04-12Bitstream added on 2014-06-13T20:10:22Z : No. of bitstreams: 1 alvarado_lg_me_botfm.pdf: 1760073 bytes, checksum: e4d09ac4f0fa7011862a2bf823b68c57 (MD5) / The improvement of a formulation involves several important steps that range from knowledge of the characteristics of the inputs used, until proof that the application is safe for commercialization. The objective of this work is to study the use of chitosan and platelet concentrates CP in the repair of epithelial tissues mainly by chronic venous wounds. This will be produced transdermal membranes chitosan CP associated with the use of cross linking agents adsorbed at various concentrations. It is estimated that nearly 3% of the population suffer from this type of injury, which rises to 10% for diabetics, and that around 4 million people are suffering from chronic injuries or have some type of complication in the process healing. Search, therefore, new features and technologies that enable the population access to a treatment effective, efficient and low cost