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1	Analysis of the relation between RNA and RBPs using machine learning / Analys av relationen mellan RNA och RBPs med hjälp av maskininlärning Wassbjer, Mattias January 2021 (has links) The study of RNA-binding proteins has recently increased in importance due to discoveries of their larger role in cellular processes. One study currently conducted at Umeå University involves constructing a model that will be able to improve our knowledge about T-cells by explaining how these cells work in different diseases. But before this model can become a reality, Umeå Univerity needs to investigate the relation between RNA and RNA-binding proteins and find proteins of which highly contribute to the activity of the RNA-binding proteins. To do so, they have decided to use four penalized regression Machine Learning models to analyse protein sequences from CD4 cells. These models consist of a ridge penalized model, an elastic net model, a neural network model, and a Bayesian model. The results show that the models have a number of RNA-binding protein sequences in common which they list as highly decisive in their predictions. Machine Learning Supervised Learning Linear Regression RNA-binding Proteins LIME T-Cells CD4 Cells K-mer Bag of Words RBP Activity Prediction Computer Sciences Datavetenskap (datalogi) Cell Biology Cellbiologi