Global ETD Search

1	Importance of tRNALys,3 structure and use in gag translation for primer selection required for replication of human immunodeficiency virus type I Yu, Wanfeng. January 2007 (has links) (PDF) Thesis (Ph. D.)--University of Alabama at Birmingham, 2007. / Title from first page of PDF file (viewed Feb. 15, 2008). Lys,3 is superscript in the title. Includes bibliographical references.
2	The function of HIV-1 A-loop on primer selection Ni, Na. January 2007 (has links) (PDF) Thesis (Ph. D.)--University of Alabama at Birmingham, 2007. / Title from first page of PDF file (viewed June 23, 2008). Includes bibliographical references.
3	Crystallographic characterization of the ribosomal binding site and molecular mechanism of action of Hygromycin A. Kaminishi, Tatsuya, Schedlbauer, Andreas, Fabbretti, Attilio, Brandi, Letizia, Ochoa Lizarralde, Borja, He, Cheng-Guang, Milon, Pohl, Connell, Sean R, Gualerzi, Claudio O, Fucini, Paola 16 November 2015 (has links) Hygromycin A (HygA) binds to the large ribosomal subunit and inhibits its peptidyl transferase (PT) activity. The presented structural and biochemical data indicate that HygA does not interfere with the initial binding of aminoacyl-tRNA to the A site, but prevents its subsequent adjustment such that it fails to act as a substrate in the PT reaction. Structurally we demonstrate that HygA binds within the peptidyl transferase center (PTC) and induces a unique conformation. Specifically in its ribosomal binding site HygA would overlap and clash with aminoacyl-A76 ribose moiety and, therefore, its primary mode of action involves sterically restricting access of the incoming aminoacyl-tRNA to the PTC. / Bizkaia:Talent and the European Union's Seventh Framework Program (Marie Curie Actions; COFUND; to S.C., A.S., T.K.); Marie Curie Actions Career Integration Grant (PCIG14-GA-2013-632072 to P.F.); Ministerio de Economía Y Competitividad (CTQ2014-55907-R to P.F., S.C.); FIRB Futuro in Ricerca from the Italian Ministero dell'Istruzione, dell'Universitá e della Ricerca (RBFR130VS5_001 to A.F.); Peruvian Programa Nacional de Innovación para la Competitividad y Productividad (382-PNICP-PIBA-2014 (to P.M. and A.F.)). Funding for open access charge: Institutional funding. / Revisión por pares Binding Sites Cinnamates X-Ray Crystallography Hygromycin B Models Molecular Peptidyl Transferases Ribosome Subunits RNA Binding Sites Cinnamates Crystallography, X-Ray Hygromycin B Models, Molecular Peptidyl Transferases Protein Synthesis Inhibitors RNA, Transfer, Amino Acyl Ribosome Subunits, Large, Bacterial

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